Nuclear RNA surveillance is the cells way of quality-checking the RNA to ensure it is a proper transcript before allowing it to continue on in its role in the cell cycle. An integral protein of RNA surveillance is Trf4, which plays a role in the determination on whether the RNA is defective of not. If it is defective, the RNA will not be able to fold into its compact structures and bind to the proteins necessary for the continuation of the cell cycle. If this happens, the RNA exosome along with proteins including TRAMP will initiate the degradation process, eliminating the RNA from the nucleus. The exosome and TRAMP are able to recognize a wide range of defective RNA substrates, allowing for a very selective process for the turnover of RNA in the cell cycle.
Nuclear Rna Surveillance Bioinformatics Tool
Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Nuclear Rna Surveillance below!
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We have 232 products for the study of the Nuclear Rna Surveillance Pathway that can be applied to Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.