Nuclear import, or the transfer of material from the cytoplasm into the cell, can happen in two ways. Smaller molecules can enter the nucleus through the pore complexes (NPCs) through the simple process of diffusion, but larger molecules require the help of a nuclear import receptor, or importin. The importins bind with the transferable material (cargo) and pass through the nuclear pore complex and into the nucleus. The presence of a nuclear localization signal (NLS) can direct the importin-cargo complex through a specific pore, enabling the process to happen more efficiently. The localization of nucleoporins and, in turn, NPC aggregates may also affect the distribution of the NPCs across the nuclear envelope. The NPCs may also be localized or clustered in order to be synthesized and degraded in an efficient manner.
Nuclear Pore Localization Bioinformatics Tool
Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Nuclear Pore Localization below!
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We have 128 products for the study of the Nuclear Pore Localization Pathway that can be applied to Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence from our catalog of antibodies and ELISA kits.