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Nuclear Pore Localization Pathway Bioinformatics

Nuclear import, or the transfer of material from the cytoplasm into the cell, can happen in two ways. Smaller molecules can enter the nucleus through the pore complexes (NPCs) through the simple process of diffusion, but larger molecules require the help of a nuclear import receptor, or importin. The importins bind with the transferable material (cargo) and pass through the nuclear pore complex and into the nucleus. The presence of a nuclear localization signal (NLS) can direct the importin-cargo complex through a specific pore, enabling the process to happen more efficiently. The localization of nucleoporins and, in turn, NPC aggregates may also affect the distribution of the NPCs across the nuclear envelope. The NPCs may also be localized or clustered in order to be synthesized and degraded in an efficient manner.

Nuclear Pore Localization Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Nuclear Pore Localization below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 128 products for the study of the Nuclear Pore Localization Pathway that can be applied to Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence from our catalog of antibodies and ELISA kits.

NBP1-87952
Immunocytochemistry/Immunofluorescence: ELYS Antibody [NBP1-87952] - Staining of human cell line A-431 shows localization to nuclear membrane. Antibody staining is shown in green. Immunohistochemistry-Paraffin: ELYS Antibody [NBP1-87952] - Staining of human placenta shows strong nuclear membrane and cytoplasmic positivity in trophoblastic cells.

Rabbit Polyclonal
Species Human
Applications ICC/IF, IHC, IHC-P

NBP2-67591
Western Blot: eIF5A Antibody (SC60-09) [NBP2-67591] - Analysis of eIF5A on different lysates using anti-eIF5A antibody at 1/1,000 dilution. Positive control: Lane 1: Jurkat Lane 2: MCF-7Immunocytochemistry/Immunofluorescence: eIF5A Antibody (SC60-09) [NBP2-67591] - Staining eIF5A in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Rabbit Monoclonal
Species Human, Mouse, Rat
Applications WB, Flow, ICC/IF

H00001069-M01
Sandwich ELISA: Centrin 2 Antibody (3F8) [H00001069-M01] - Detection limit for recombinant GST tagged CETN2 is approximately 0.1ng/ml as a capture antibody.

Mouse Monoclonal
Species Human
Applications WB, ELISA

1 Publication
NBP1-86184
Western Blot: EIF5 Antibody [NBP1-86184] - Analysis in U2OS cells transfected with control siRNA, target specific siRNA probe #1 and #2. Remaining relative intensity is presented.Immunocytochemistry/Immunofluorescence: EIF5 Antibody [NBP1-86184] - Staining  of human cell line U-2 OS shows positivity in cytoplasm.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

NBP1-83213
Western Blot: AGFG2 Antibody [NBP1-83213] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).Immunohistochemistry-Paraffin: AGFG2 Antibody [NBP1-83213] - Staining in human salivary gland and skeletal muscle tissues using anti-AGFG2 antibody. Corresponding AGFG2 RNA-seq data are presented for the same tissues.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

NBP2-23718
Immunohistochemistry-Paraffin: NUP160 Antibody [NBP2-23718] - Analysis of NUP160 in formalin-fixed, paraffin-embedded human brain tissue using preimmune sera (top) and this antibody (bottom) at 1:100.

Rabbit Polyclonal
Species Human, Bovine, Equine
Applications IHC-P

NB100-93329
Western Blot: Nup153 Antibody [NB100-93329] - Detection of Human NUP153 on HeLa whole cell lysate using NB100-9329. NUP153 was also immunoprecipitated by rabbit anti-NUP153 antibody NB100-9330.Immunocytochemistry/Immunofluorescence: Nup153 Antibody [NB100-93329] - Formaldehyde-fixed asynchronous HeLa cells.  Antibody: Affinity purified rabbit anti-NUP153   used at a dilution of 1:200 (1ug/ml). Detection: Red-fluorescent goat anti-rabbit IgG highly cross adsorbed Antibody used at a dilution of 1:100.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IP

     2 Reviews

1 Publication
NB100-79802
Western Blot: CRM1 Antibody [NB100-79802] - Detection of Human and Mouse CRM1 by Western Blot. Samples: Whole cell lysate (50 ug) prepared using NETN buffer from HeLa, 293T, Jurkat, and mouse TCMK-1 cells. Antibodies: Affinity purified rabbit anti-CRM1 antibody NB100-79802 used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.Immunohistochemistry: CRM1 Antibody [NB100-79802] - Sample: FFPE section of mouse teratoma. Antibody: Affinity purified rabbit anti-CRM1 used at a dilution of 1:1,000 (1ug/ml). Detection: DAB

Rabbit Polyclonal
Species Human, Mouse
Applications WB, Simple Western, ICC/IF

4 Publications
NB100-93324
Western Blot: NUP50 Antibody [NB100-93324] - MDA-MB-231 nuclear extract. Cells infected with lentivirus coding scramble shRNA or one of two NUP50 targeting shRNAs. Image from verified customer review.Immunohistochemistry: NUP50 Antibody [NB100-93324] - Sample: FFPE section of human prostate carcinoma (left) and mouse teratoma (right). Antibody: Affinity purified rabbit anti- NUP50 used at a dilution of 1:200 (1ug/ml). Detection: DAB

Rabbit Polyclonal
Species Human, Mouse
Applications WB, IHC, IHC-P

     1 Review

1 Publication

Related Genes

The Nuclear Pore Localization Pathway has been researched against:

Related Diseases

The Nuclear Pore Localization Pathway has been studied in relation to diseases such as: