Nuclear pore complexes (NPCs) are tiny holes in the nuclear envelope that allow for material to pass into and out of the nucleus. NPC assembly must occur both at the end of mitosis as well as when the nucleus and nuclear envelope expand during metabolic cell growth. The mechanism of assembly of these nuclear pore complexes is still being debated by the scientific community, but there are currently three methods that have been presented with evidence. One method of NPC assembly is that the pore complexes being to appear after the nuclear envelope regrows following nuclear division. Protein complexes called Nup complexes bind to the chromatin, and then are inserted into the double membrane, causing the two to fuse together around the protein. The idea of a prepore also exists, where several Nup complexes come together and allow the nuclear envelope to form around them during the regrowth of the membrane. The prepore would begin in the nucleus, after previously going through active transport from the cytoplasm. The final mechanism of NPC assembly occurs when more promoters are added to an existing NPC, allowing for the further growth of the pore complexes.
Nuclear Pore Complex Assembly Bioinformatics Tool
Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Nuclear Pore Complex Assembly below!
For more information on how to use Laverne, please read the How to Guide.
We have 464 products for the study of the Nuclear Pore Complex Assembly Pathway that can be applied to Western Blot, Immunocytochemistry/Immunofluorescence, Flow Cytometry, Immunohistochemistry from our catalog of antibodies and ELISA kits.
PRODUCT AVAILABILITY: Update Regarding the Evolving COVID-19 Situation
Bio-Techne appreciates the critical role that you and our products and services play in research efforts to further scientific innovation and discovery. We are continually assessing our manufacturing and supplier capabilities during the COVID-19 situation and are implementing precautionary measures to ensure uninterrupted supply of products and services. Currently, and as we abide by local shelter in place orders across the world, we are fully operational and do not anticipate any material supply disruptions across our Bio-Techne brands and product lines. As the situation evolves, our goal is to utilize preventive measures to reduce the threat that COVID-19 poses to our ability to meet the needs of our customers globally.