Nuclear pore complexes (NPCs) are tiny holes in the nuclear envelope that allow for material to pass into and out of the nucleus. NPC assembly must occur both at the end of mitosis as well as when the nucleus and nuclear envelope expand during metabolic cell growth. The mechanism of assembly of these nuclear pore complexes is still being debated by the scientific community, but there are currently three methods that have been presented with evidence. One method of NPC assembly is that the pore complexes being to appear after the nuclear envelope regrows following nuclear division. Protein complexes called Nup complexes bind to the chromatin, and then are inserted into the double membrane, causing the two to fuse together around the protein. The idea of a prepore also exists, where several Nup complexes come together and allow the nuclear envelope to form around them during the regrowth of the membrane. The prepore would begin in the nucleus, after previously going through active transport from the cytoplasm. The final mechanism of NPC assembly occurs when more promoters are added to an existing NPC, allowing for the further growth of the pore complexes.
Nuclear Pore Complex Assembly Bioinformatics Tool
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