Nuclear envelope disassembly is an event that in normal conditions occurs at the beginning of the prometaphase of mitosis and meiosis, in which the nuclear envelope essentially breaks down in order to allow the spindles coming from the centrosomes to attach to the kinetochores of the chromosomes or the opposing microtubules. The mechanism of the breakdown of the nuclear envelope is not well known by the scientific community, but it has been shown that and active maturation-promoting factor catalyzes the dispersal of nucleoporins from their nuclear pore complexes is what initiates this process. The dispersal of the necleoporins cause holes to being to appear in the nuclear envelope, and the presence of the microtubules coming from the centromeres further facilitates the degradation. Lamina depolarization and dissociation of INM proteins follow, completing the process of the nuclear envelope disassembly.
Nuclear Envelope Disassembly Bioinformatics Tool
Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Nuclear Envelope Disassembly below!
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We have 1291 products for the study of the Nuclear Envelope Disassembly Pathway that can be applied to Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Chromatin Immunoprecipitation (ChIP), Immunohistochemistry from our catalog of antibodies and ELISA kits.