The function of nerve growth factors (NGFs) is to aid in axonal growth by binding with two kinds of receptors located on the neuron: p75 LNGFR neurotrophin receptor and TrkA. Both of these receptors have been shown to be affected under conditions that are associated with neurodegenerative diseases. There a multiple pathways that can be activated by the binding of NGFs to its receptors, including PI 3-kinase, Ras, and PLC signaling pathways, which not only lead to cell growth and proliferation but to the activation of kinases such as Akt and MAPK. If bonded to TrkA, the NGFs may undergo internalization via a clathrin-coated pit, but due to a lack of endosomal NGF degradation enzymes, many of the proteins are recycled back into the body and can continue their duties of regulating neuronal growth and other forms of homeostasis.
Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Nerve Growth Factor Processing below!
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We have 820 products for the study of the Nerve Growth Factor Processing Pathway that can be applied to Flow Cytometry, Western Blot, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.