The mitotic nuclear envelope disassembly is an event that occurs at the beginning of the prometaphase of mitosis, in which the nuclear envelope essentially breaks down in order to allow the spindles coming from the centrosomes to attach to the kinetochores of the chromosomes or the opposing microtubules. The mechanism of the breakdown of the nuclear envelope is not well known by the scientific community, but it has been shown that the dispersal of nucleoporins from their nuclear pore complexes is what initiates this process. The dispersal of the necleoporins cause holes to being to appear in the nuclear envelope, and the presence of the microtubules coming from the centromeres further facilitates the degradation. Lamina depolarization and dissociation of INM proteins follow, completing the process of the nuclear envelope disassembly.
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