The MAPK pathway is made up of multiple cascades which can lead to a variety of cellular functions including proliferation, differentiation, apoptosis, and cell survival. There are a number of different stimuli and factors that can initiate the MAPK cascades, such as growth factors that bind to RTKs, proinflammatory cytokines, heat shock, and osmotic stress. The signaling molecule causes dimerization of the RTKs, which causes the binding of GRB2 and SOS leading to the Ras-GDP complex to become Ras-GTP. This initiates a phosphorylation cascade of molecules such as MEK and ERK, which activate transcription factors in the AP1 family and begin the process of growth and proliferation. In typical instances of the MAPK pathway, the Ras-GTP complex is inactivated shortly after its activation. When this process is deregulated, it can lead to the increase in the proliferation and cell survival that is seen in progressing tumors.
Mapk Cascade Bioinformatics Tool
Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Mapk Cascade below!
For more information on how to use Laverne, please read the How to Guide.
We have 763 products for the study of the Mapk Cascade Pathway that can be applied to Chromatin Immunoprecipitation, Western Blot, Immunocytochemistry/Immunofluorescence, Flow Cytometry, Immunohistochemistry from our catalog of antibodies and ELISA kits.
PRODUCT AVAILABILITY: Update Regarding the Evolving COVID-19 Situation
Bio-Techne appreciates the critical role that you and our products and services play in research efforts to further scientific innovation and discovery. We are continually assessing our manufacturing and supplier capabilities during the COVID-19 situation and are implementing precautionary measures to ensure uninterrupted supply of products and services. Currently, and as we abide by local shelter in place orders across the world, we are fully operational and do not anticipate any material supply disruptions across our Bio-Techne brands and product lines. As the situation evolves, our goal is to utilize preventive measures to reduce the threat that COVID-19 poses to our ability to meet the needs of our customers globally.