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Lymphangiogenesis Pathway Bioinformatics

Lymphangiogenesis is a phenomenon similar to angiogenesis, in which new lymphatic vessels are formed from pre-existing ones in a method termed sprouting that is initiated by the signaling molecule VEGF-C. Lymphangiogenesis is necessary in establishing homeostasis as well as metabolism and immunity, as many organs of the body require the vessels to transfer their dangerous and unnecessary cells to the lymph nodes in order to properly function. Lymphangiogenesis can, however, help in the progression of diseases such as rheumatoid arthritis, impaired wound healing, and cancer metastasis. If tumor cells are able to reach the lymphatic vessels, they can use them to further travel around the body to the lymph nodes, which can result in a lack of the disease fighting functions that the lymph nodes typically have.

Lymphangiogenesis Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Lymphangiogenesis below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 1821 products for the study of the Lymphangiogenesis Pathway that can be applied to Western Blot, Chromatin Immunoprecipitation, Immunocytochemistry/Immunofluorescence, Flow Cytometry, Immunohistochemistry from our catalog of antibodies and ELISA kits.

AF743
bEnd.3 cells, a mouse endothelioma cell line, was stained with Goat Anti-Mouse VEGF R3/Flt‑4 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF743, filled histogram) or isotype control antibody (Catalog # <a class=

Goat Polyclonal
Species Mouse
Applications WB, Flow, CyTOF-ready

     5 Reviews

44 Publications
AF2125
  Western  blot shows lysates of mouse liver tissue and bEnd.3 mouse brain  endothelial  cell line. PVDF membrane  was probed with 0.25 µg/mL of Goat Anti-Mouse LYVE‑1  Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2125) followed by  HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class=LYVE‑1 was detected in perfusion fixed frozen sections of mouse liver using 15 µg/mL Goat Anti-Mouse LYVE‑1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2125) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit  (brown; Catalog # <a class=

Goat Polyclonal
Species Mouse
Applications WB, IHC

     3 Reviews

26 Publications
NB600-1015
Western Blot: Podoplanin Antibody (8.1.1) [NB600-1015] - Analysis of Podoplanin in mouse kidney tissue extract.Immunocytochemistry/Immunofluorescence: Podoplanin Antibody (8.1.1) [NB600-1015] - Podoplanin (8.1.1) antibody labeling (green) of glomeruli from mouse kidney. Nuclei were counterstained with Dapi (blue).

Golden Syrian Hamster Monoclonal
Species Mouse, Human (Negative)
Applications WB, EM, Flow

     1 Review

15 Publications
NB100-1642
Immunocytochemistry/Immunofluorescence: CD31/PECAM-1 Antibody (MEC 7.46) [NB100-1642] - MS1 cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.5% Triton-X100.  The cells were incubated with anti-CD31/PECAM-1 (MEC 7.46) at 5.0 ug/ml overnight at 4C and detected with an anti-mouse Dylight 488 (Green) at a 1:500 dilution.  Actin was detected with Phalloidin 568 (Red) at a 1:200 dilution.  Nuclei were counterstained with DAPI (Blue).  Cells were imaged using a 40X objective.Flow (Cell Surface): CD31/PECAM-1 Antibody (MEC 7.46) [NB100-1642] - A surface stain was performed on MS-1 Cells with CD31 (MEC 7.46) antibody NB100-1642(blue) and a matched isotype control (orange). Cells were incubated in an antibody dilution of 2.5 ug/mL for 20 minutes at room temperature, followed by rat F(ab)2 IgG (H+L) APC-conjugated secondary antibody (F0113, R&D Systems).

Rat Monoclonal
Species Mouse
Applications Flow, ICC/IF, IHC

18 Publications
AF644
Recombinant Mouse VEGF R2/KDR/Flk‑1 Fc Chimera (Catalog # <A class=NoLineLink href=VEGF R2/KDR/Flk‑1 was detected in immersion fixed frozen sections of mouse embryo (14 d.p.c.) using 15 µg/mL Mouse VEGF R2/KDR/Flk‑1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF644) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit  (brown; Catalog # <A class=

Goat Polyclonal
Species Mouse
Applications WB, Flow, IHC

     2 Reviews

37 Publications
NB110-41083

Goat Polyclonal
Species Human
Applications WB, ChIP, ELISA

10 Publications
233-FB/CF
Recombinant Human FGF basic (146aa) (Catalog # 233-FB/CF) stimulates cell proliferation of the NR6R‑3T3 mouse fibroblast cell line. The ED<sub>50</sub> for this effect is 0.1-0.6 ng/mL.1 µg/lane of Recombinant Human FGF basic (146 aa) was resolved by SDS-PAGE with silver staining, under reducing (R) conditions, showing a band at 17 kDa.


Species Human

179 Publications
NBP1-33050
Western Blot: MVD Antibody [NBP1-33050] - A. 30 ug 293T whole lysate/extract, B. 30 ug A431 whole cell lysate/extract, C. 30 ug HeLa whole cell lysate/extract. D. 30 ug A37C whole cell lysate/extract 10 % SDS-PAGE gel, antibody dilution 1:1000.Immunocytochemistry/Immunofluorescence: MVD Antibody [NBP1-33050] - Paraformaldehyde-fixed HeLa, using antibody at 1:200 dilution.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ICC/IF, IHC

NB600-1071
Immunocytochemistry/Immunofluorescence: CD34 Antibody (MEC 14.7) [NB600-1071] - CD34 antibody was tested in WEHI-3 cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red).Immunohistochemistry-Paraffin: CD34 Antibody (MEC 14.7) [NB600-1071] - IHC analysis of a formalin fixed and paraffin embedded tissue section of mouse small intestine using rat anti-mouse CD34 (clone MEC 14.7) at 1:100 dilution. The signal was developed using HRP-conjugated anti-rat secondary with DAB reagent which followed counterstaining of nuclei using hematoxylin. This antibody specifically labelled the endothelial cells in blood vessels located primarily in the sub-mucosa, and of that of the mucosa muscularis and the mucosal lacteal.

Rat Monoclonal
Species Mouse, Rat
Applications WB, ELISA, Flow

17 Publications
AF2727
Western blot shows lysates of HepG2 human hepatocellular carcinoma cell line. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human Prox1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2727) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <A class=NoLineLink href=Prox1 was detected in immersion fixed HepG2 human hepatocellular carcinoma cell line using Goat Anti-Human Prox1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2727) at 15 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (left panel, red; Catalog # <a class=

Goat Polyclonal
Species Human
Applications WB, Simple Western, ICC

     4 Reviews

37 Publications
MAB328
Recombinant Human CCL16/<BR>HCC‑4 (Catalog # <A class=NoLineLink href=

Mouse Monoclonal
Species Human
Applications WB, IHC, CyTOF-ready

1 Publication