Insulin is a peptide hormone that is responsible for helping with the regulation of carbohydrate and fat metabolism, as it causes the cells of various tissues to absorb glucose in various forms from the bloodstream. Once the insulin is released into the bloodstream, it binds with the insulin receptor tyrosine kinase, which autophosphorylates and starts a multitude of cascades through different signaling molecules, which include Akt and PKB. The cascades can lead to functions such as cell growth, glucose and lipid homeostasis, apoptosis, and the influx of glucose into the cell, which occurs due to the movement of GLUT4 vesicles to the membrane, which creates a glucose transmembrane channel. Deficiencies in insulin or resistance to the protein can lead to glucose not being able to enter the cell, which can result in diseases including diabetes mellitus and polycystic ovary syndrome.
Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Insulin Receptor Signaling Pathway below!
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We have 1285 products for the study of the Insulin Receptor Signaling Pathway that can be applied to Western Blot, Flow Cytometry, Chromatin Immunoprecipitation, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.