Insulin is a peptide hormone that is responsible for helping with the regulation of carbohydrate and fat metabolism, as it causes the cells of various tissues to absorb glucose in various forms from the bloodstream. Insulin binds to receptors on the surface of these tissue cells, and through several signaling cascades, allows glucose to enter the cell. Insulin can also have an influence on cell activity including increasing potassium uptake and decreasing autophagy. Once insulin has successfully docked to a receptor, it is either degraded by the cell it is attached to or it is released back into the extracellular space and is then degraded by either the liver or the kidney. The insulin receptor, which is a tyrosine kinase receptor, is then internalized into the cell via clathrin-coated pits. The insulin is then released from the receptor to be degraded by endosomes and lysosomes, while the receptors are recycled back to the cell surface. The rate of recycling of insulin receptors can be increased with phorbol myristate acetate. Deficiencies in insulin or resistance to the protein can lead to diseases including diabetes mellitus and polycystic ovary syndrome.
Insulin Receptor Recycling Bioinformatics Tool
Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Insulin Receptor Recycling below!
For more information on how to use Laverne, please read the How to Guide.
We have 1150 products for the study of the Insulin Receptor Recycling Pathway that can be applied to Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.