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Insulin Receptor Recycling Pathway Bioinformatics

Insulin is a peptide hormone that is responsible for helping with the regulation of carbohydrate and fat metabolism, as it causes the cells of various tissues to absorb glucose in various forms from the bloodstream. Insulin binds to receptors on the surface of these tissue cells, and through several signaling cascades, allows glucose to enter the cell. Insulin can also have an influence on cell activity including increasing potassium uptake and decreasing autophagy. Once insulin has successfully docked to a receptor, it is either degraded by the cell it is attached to or it is released back into the extracellular space and is then degraded by either the liver or the kidney. The insulin receptor, which is a tyrosine kinase receptor, is then internalized into the cell via clathrin-coated pits. The insulin is then released from the receptor to be degraded by endosomes and lysosomes, while the receptors are recycled back to the cell surface. The rate of recycling of insulin receptors can be increased with phorbol myristate acetate. Deficiencies in insulin or resistance to the protein can lead to diseases including diabetes mellitus and polycystic ovary syndrome.

Insulin Receptor Recycling Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Insulin Receptor Recycling below! For more information on how to use Laverne, please read the How to Guide.
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Top Research Reagents

We have 1150 products for the study of the Insulin Receptor Recycling Pathway that can be applied to Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.

Western Blot: PRDM10 Antibody [NBP1-81427] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10<br/>Lane 2: Negative control (vector only transfected HEK293T lysate)<br/>Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY404561)Immunocytochemistry/Immunofluorescence: PRDM10 Antibody [NBP1-81427] - Staining of human cell line A-431 shows positivity in nucleoli, vesicles & nucleus but excluded from the nucleoli. Antibody staining is shown in green.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

Western Blot: Hsp70 / Hsc70 Antibody (13D3) [NB120-2788] - Proteins were transferred to a PVDF membrane and blocked with 5% BSA/TBST for at least 1 hour. The membrane was probed with a HSP70 monoclonal antibody at a dilution of 1:1000 overnight at 4C on a rocking platform, washed in TBS-0.1%Tween 20, and probed with a goat anti-mouse IgM-HRP secondary antibody at a dilution of 1:20,000 for at least 1 hour.Immunocytochemistry/Immunofluorescence: Hsp70 / Hsc70 Antibody (13D3) [NB120-2788] - Analysis of HSC70 using Monoclonal antibody (13D3) shows staining in NIH-3T3 cells. HSC70 staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing HSC70 at a dilution of 1:20-1:200 over night at 4C, washed with PBS and incubated with a DyLight-488 conjugated.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, B/N, Flow

     2 Reviews

11 Publications
Western Blot: Adenine Nucleotide Translocase 1 Antibody [NBP1-59594] - RPMI 8226 cell lysate, concentration 0.2-1 ug/ml.Immunocytochemistry/Immunofluorescence: Adenine Nucleotide Translocase 1 Antibody [NBP1-59594] - Formalin Fixed Paraffin; Embedded Tissue: Human Pineal Tissue; Observed Staining: Cytoplasmic in cell bodies of pinealocytes and their processes; Primary Antibody Concentration: 1:100

Rabbit Polyclonal
Species Human, Rat
Applications WB, ICC/IF

Western Blot: CD5 Antibody (7A7) [NBP2-02690] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CD5 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CD5.Immunocytochemistry/Immunofluorescence: CD5 Antibody (7A7) [NBP2-02690] Staining of COS7 cells transiently transfected by pCMV6-ENTRY CD5.

Mouse Monoclonal
Species Human
Applications WB, Flow, ICC/IF


Rabbit Polyclonal
Species Human, Mouse, Bovine
Applications WB, ICC/IF, IP

1 Publication
Western Blot: HspA4 Antibody [NBP1-81696] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells), Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells).Immunocytochemistry/Immunofluorescence: HspA4 Antibody [NBP1-81696] - Staining of human cell line A-431 shows positivity in nucleus but not nucleoli & cytoplasm.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

1 Publication
Western Blot: ACAA2 Antibody (1C10) [NBP2-46477] - Analysis of extracts (35ug) from 9 different cell lines (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).Immunohistochemistry: ACAA2 Antibody (1C10) [NBP2-46477] - Analysis of Human endometrium tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min)

Mouse monoclonal
Species Human, Canine
Applications WB, IHC, IF

Related Genes

The Insulin Receptor Recycling Pathway has been researched against:

Related Diseases

The Insulin Receptor Recycling Pathway has been studied in relation to diseases such as:

Related PTMs

The Insulin Receptor Recycling Pathway has been studied in relation to posttranslational modifications (PTMs) including: