Induction Of Apoptosis By P53 Pathway Bioinformatics
Apoptosis is a form of programmed cell death, which can be either a developmental process or a response from the human immune system. During apoptosis, the cell undergoes changes including chromosomal condensation, nuclear and chromosomal DNA fragmentation, and blebbing. There are two mechanisms used in the induction of apoptosis, via intrinsic and extrinsic pathways. The intrinsic pathway occurs when irreparable DNA lesions are found in the nucleus, and a number of cascades occur, including the p53 pathway. When p53 receives information that there is damage to the cell, it triggers the BAX protein to move to the nuclear membrane and open an ion channel. The influx of ions causes cytochrome C to leak into the cytosol, where it interacts with procaspase-9, cleaving it into its active form of caspase-9. Caspase-9 then initiates several caspase cascades, resulting in the destruction of cellular components that is essential in an apoptosis event. Current research is being done to find a chemical induction of apoptosis to target diseased cells such as cancer cells.
Induction Of Apoptosis By P53 Bioinformatics Tool
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