The epidermal growth factor receptor signaling pathway (EGFR pathway) occurs when an epidermal growth factors binds to the receptor. Ligand binding occurs and the shape of the EGFR changes, which allows for dimerization and phosphorylation of the tyrosine kinase domain. The phosphorylation can lead to the signaling molecule RAS to become activated, which activates a signaling cascade that results in the MEK molecule signaling transcription. There are multiple other signaling cascades that lead to transcription as well such as the MAPK and JNK pathways. The EGFR pathway is commonly seen in solid tumor growth and metastasis in cancers such as thyroid cancer.
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We have 1641 products for the study of the Epidermal Growth Factor Receptor Signaling Pathway that can be applied to Chromatin Immunoprecipitation, Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.