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X-linked Infantile Spasm Syndrome: Disease Bioinformatics

X-linked Infantile Spasm Syndrome is a condition occurring in babies and small children that causes bouts of seizures. These seizures usually end up causing a slowing in typical development such as sitting up or rolling over. Although the seizures associated with X-linked Infantile Spasm Syndrome often disappear by the time the child reaches the age of five, most children often develop other forms of seizures that are often associated with mental retardation. Because it is an X-linked disease, X-linked Infantile Spasm Syndrome is a disease that is passed on through the X-chromosome, specifically by mutations on either the ARX gene or the CDKL5 gene. Although there is no cure, treatment options are available to ease symptoms.

X-linked Infantile Spasm Syndrome Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on X-linked Infantile Spasm Syndrome below! For more information on how to use Laverne, please read the How to Guide.
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Top Research Reagents

We have 302 products for the study of X-linked Infantile Spasm Syndrome that can be applied to Western Blot, Chromatin Immunoprecipitation, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.

AF7068
Western blot shows lysates of U‑87 MG human glioblastoma/astrocytoma cell line, U‑118‑MG human glioblastoma/astrocytoma cell line, and human brain (cortex) tissue. PVDF membrane was probed with 2 µg/mL of Sheep Anti-Human ARX Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7068) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # <A class=NoLineLink href=ARX was detected in immersion fixed U‑87 MG human glioblastoma/astrocytoma cell line using Sheep Anti-Human ARX Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7068) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Sheep IgG Secondary Antibody (red, upper panel; Catalog # <a class=

Sheep Polyclonal
Species Human
Applications WB, IHC, ICC

NBP1-84881
Western Blot: CDKL5 Antibody [NBP1-84881] - Analysis in control (vector only transfected HEK293T lysate) and CDKL5 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).Immunocytochemistry/Immunofluorescence: CDKL5 Antibody [NBP1-84881] - Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm. Antibody staining is shown in green.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

1 Publication
NB120-22104
Western Blot: SAE2 Antibody [NB120-22104] - Western bot analysis of SAE2 in HeLa cell lysate using NB120-22104 at 1.0 ug/ml.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB

4 Publications
NB100-56326
Western Blot: MeCP2 Antibody [NB100-56326] - Analysis of MeCP2 in HeLa cell lysate using this antibody.Immunocytochemistry/Immunofluorescence: MeCP2 Antibody [NB100-56326] - MeCP2 antibody was tested in A431 cells at a 1:200 dilution against Dylight 488 (Green). Alpha tubulin and nuclei were counterstained against Dylight 568 (Red) and DAPI (Blue), respectively.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ICC/IF, IHC

1 Publication
H00009211-P01
Western Blot: Recombinant Human Lgi1 Protein [H00009211-P01] - The human recombinant LGI1 protein is recognized by a commercial antibody against LGI1. Lane 2: 0.4 ug; Lane 3: 0.2 ug). Lane 4: no protein. Image from verified customer review.Recombinant Human Lgi1 Protein [H00009211-P01] - 12.5% SDS-PAGE Stained with Coomassie Blue.


Species Human

     1 Review

NBP1-21672
Western Blot: SAP102 Antibody (S19-2) [NBP1-21672] - Rat brain extractImmunocytochemistry/Immunofluorescence: SAP102 Antibody (S19-2) [NBP1-21672] - analysis using Mouse Anti-SAP102 Monoclonal Antibody, Clone S19-2. Tissue: Neuroblastoma cell line SK-N-BE. Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-SAP102 Monoclonal Antibody at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cytoplasm. Magnification: 60X.

Mouse Monoclonal
Species Rat
Applications WB, ICC/IF, IHC

1 Publication
H00004004-M01
Immunocytochemistry/Immunofluorescence: LMO1 Antibody (4F7) [H00004004-M01] - Analysis of monoclonal antibody to LMO1 on HeLa cell. Antibody concentration 10 ug/ml.

Mouse Monoclonal
Species Human
Applications WB, ELISA, ICC/IF

NBP1-84310
Western Blot: BRD2 Antibody [NBP1-84310] - Analysis in human cell lines HEK293 and MCF-7 using Anti-BRD2 antibody. Corresponding BRD2 RNA-seq data are presented for the same cell lines. Loading control: Anti-HSP90B1.Immunocytochemistry/Immunofluorescence: BRD2 Antibody [NBP1-84310] - Staining of human cell line U-2 OS shows positivity in nucleus but not nucleoli.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

NBP2-66897
Western Blot: ID1 Antibody (JM92-13) [NBP2-66897] - Analysis of Id1 on 293T cell using anti-Id1 antibody at 1/1,000 dilution.Immunocytochemistry/Immunofluorescence: ID1 Antibody (JM92-13) [NBP2-66897] - Staining Id1 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Rabbit Monoclonal
Species Human
Applications WB, Flow, ICC/IF

NBP2-42173
Western Blot: NHLRC1 Antibody (S85-18) [NBP2-42173] - analysis of Monkey COS cells transfected with flag-tagged Malin showing detection of 42 kDa Malin protein using Mouse Anti-Malin Monoclonal Antibody, Clone S85-18. Lane 1: Molecular Weight Ladder. Lane 2: Monkey COS cells transfected with flag-tagged Malin. Load: 15 ug. Block: 2% BSA and 2% Skim Milk in 1X TBST. Primary Antibody: Mouse Anti-Malin Monoclonal Antibody at 1:200 for 16 hours at 4C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:1000 for 1 hour RT. Color Development: ECL solution for 6 min in RT. Predicted/Observed Size: 42 kDa.Immunocytochemistry/Immunofluorescence: NHLRC1 Antibody (S85-18) [NBP2-42173] - Tissue: Neuroblastoma cell line SK-N-BE. Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-Malin Monoclonal Antibody at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60min RT, 5min RT. Localization: Cytoplasm, Endoplasmic Reticulum. Magnification: 60X.

Mouse Monoclonal
Species Human
Applications WB, ICC/IF, ICC

NBP2-67584
Western Blot: Radixin Antibody (SC06-22) [NBP2-67584] - Analysis of Radixin on different lysates using anti-Radixin antibody at 1/1,000 dilution. Positive control: Lane 1: Hela Lane 2: A431 Lane 3: HepG2Immunocytochemistry/Immunofluorescence: Radixin Antibody (SC06-22) [NBP2-67584] - Staining Radixin in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Rabbit Monoclonal
Species Human, Mouse, Rat
Applications WB, Flow, ICC/IF

NBP2-24716
Western Blot: MTSS1 Antibody [NBP2-24716] - Analysis of MTSS1 in human testis lysate in the 1) absence and 2) presence of immunizing peptide, 3) mouse and 4) rat testis lysate using NBP2-24716 at 2 ug/ml, 4 ug/ml and 2 ug/ml, respectively.Immunohistochemistry-Paraffin: MTSS1 Antibody [NBP2-24716] - Analysis of human colon using this antibody at 10 ug/ml.

Rabbit Polyclonal
Species Human, Primate
Applications WB, IHC-P

1 Publication
NBP1-57508
Western Blot: Exosome component 6 Antibody [NBP1-57508] - Jurkat cell lysate, Antibody Titration: 5.0ug/mlImmunohistochemistry-Paraffin: Exosome component 6 Antibody [NBP1-57508] - Human Muscle Tissue, Skeletal muscle cells (Indicated with Arrows) 4-8ug/ml.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

NBP1-85585
Immunocytochemistry/Immunofluorescence: CLCN2 Antibody [NBP1-85585] - Staining of human cell line CACO-2 shows localization to cytosol. Antibody staining is shown in green.Immunohistochemistry-Paraffin: CLCN2 Antibody [NBP1-85585] - Staining of human testis shows strong cytoplasmic positivity in Leydig cells.

Rabbit Polyclonal
Species Human
Applications ICC/IF, IHC, IHC-P

NBP1-49833
Western Blot: TPPP/p25 Antibody [NBP1-49833] - (0.001ug/ml) staining of Mouse (A) and Rat (B) Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescenceImmunohistochemistry-Paraffin: TPPP/p25 Antibody [NBP1-49833] -  Staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Goat Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC, IHC-P

2 Publications
NBP1-89284
Western Blot: ACAT1 Antibody [NBP1-89284] - Analysis using Anti-ACAT1 antibody NBP1-89284 (A) shows similar pattern to independent antibody NBP1-89285 (B).Immunocytochemistry/Immunofluorescence: ACAT1 Antibody [NBP1-89284] - Immunofluorescent staining of human cell line U-2 OS shows localization to mitochondria. Antibody staining is shown in green.

Rabbit Polyclonal
Species Human, Porcine
Applications WB, ICC/IF, IHC

     1 Review

5 Publications
NBP1-82458
Immunohistochemistry-Paraffin: P11 Antibody [NBP1-82458] - Staining of human lymph node.Immunohistochemistry-Paraffin: P11 Antibody [NBP1-82458] - Staining of human placenta shows strong cytoplasmic positivity in trophoblastic cells.

Rabbit Polyclonal
Species Human
Applications IHC, IHC-P

H00023096-B01P-50ug
Western Blot: IQSEC2 Antibody [H00023096-B01P-50ug] - Analysis of IQSEC2 expression in transfected 293T cell line (H00023096-T01) by IQSEC2 MaxPab polyclonal antibody.  Lane 1: IQSEC2 transfected lysate(104.39 KDa). Lane 2: Non-transfected lysate.

Mouse Polyclonal
Species Human
Applications WB


Related Genes

X-linked Infantile Spasm Syndrome has been researched against:

Related Pathways

X-linked Infantile Spasm Syndrome has been linked to:

Related PTMs

X-linked Infantile Spasm Syndrome has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

X-linked Infantile Spasm Syndrome is also known as X-linked Infantile Spasms.