Submit your image related to Diseases to be featured!

Get Social

Submit your Twitter account related to X-linked Dyskeratosis Congenita to be featured!

Blogs

Submit your blog on X-linked Dyskeratosis Congenita to be featured!

Events

Submit your event on X-linked Dyskeratosis Congenita to be featured!

Videos

Submit your video on X-linked Dyskeratosis Congenita to be featured!

Charities

Submit your charity on X-linked Dyskeratosis Congenita to be featured!

X-linked Dyskeratosis Congenita: Disease Bioinformatics

X-linked Dyskeratosis Congenita is a rare disease that causes premature aging and is associated with abnormal or lacy skin coloring, poor nail health, lesions in the mucous membranes of the mouth, and bone marrow dysfunction. X-linked Dyskeratosis Congenita is caused by mutations in the genes responsible for making and maintaining telomeres, the ends of the chromosomes that stop the chromosomes from dividing too quickly, destructing, or sticking to other chromosomes. A person who has X-linked Dyskeratosis Congenita is more susceptible to developing leukemia, aplastic anemia, lung problems, bone marrow failure, and other cancers. A person is typically diagnosed with X-Linked Dyskeratosis Congenita as a child, but the severity of the disease has a broad spectrum. Because it is an x-linked disease that is passed down genetically, boys are more likely to have it than girls.

X-linked Dyskeratosis Congenita Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on X-linked Dyskeratosis Congenita below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 764 products for the study of X-linked Dyskeratosis Congenita that can be applied to Western Blot, Chromatin Immunoprecipitation, Flow Cytometry, Chromatin Immunoprecipitation (ChIP), Immunohistochemistry, Immunocytochemistry/Immunofluorescence from our catalog of antibodies and ELISA kits.

NBP1-85156
Western Blot: DKC1 Antibody [NBP1-85156] - Lane 1: Marker [kDa] 206, 113, 82, 49, 32, 26, 18 Lane 2: Human cell line RT-4 Lane 3: Human cell line U-251MG sp Lane 4: Human cell line A-431 Lane 5: Human liver tissue Lane 6: Human tonsil tissueImmunohistochemistry-Paraffin: DKC1 Antibody [NBP1-85156] - Staining of human cerebral cortex shows strong nucleolar positivity in neuronal cells.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

4 Publications
NBP1-92684
Western Blot: Doublecortin Antibody (3E1) [NBP1-92684] - Analysis of rat whole brain lysates using mouse mAb to Doublecortin (DCX), NBP1-92684, dilution 1:1,000 in green: [1] protein standard (red), [2] adult rat brain, [3] embryonic E20 rat brain. Strong bands at 40, 45kDa correspond to DCX protein, detected only in the developing brain.Immunocytochemistry/Immunofluorescence: Doublecortin Antibody (3E1) [NBP1-92684] - Analysis of cortical neuron-glial cell culture from E20 rat stained with mouse mAb to Doublecortin (DCX), NBP1-92684, dilution 1:1,000 in red, and costained with chicken pAb to Microtubule Associated Protein2 (MAP2), dilution 1:10,000 in green. The blue is DAPI staining of nuclear DNA. DCX antibody reveals strong cytoplasmic staining in a population of small developing neurons and their processes, while MAP2 antibody stains dendrites and perikarya of mature neurons. Therefore DCX antibody is an excellent marker of developing neuronal cells.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

NBP1-57138
Western Blot: RNPC3 Antibody [NBP1-57138] - Human Spleen lysate, concentration 0.2-1 ug/ml.

Rabbit Polyclonal
Species Human
Applications WB

NBP1-92388
Immunocytochemistry/Immunofluorescence: SHQ1 Antibody [NBP1-92388] - Staining of human cell line A-431 shows localization to nucleoplasm. Antibody staining is shown in green.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

1 Publication
NB100-317
Western Blot: TERT Antibody (2C4) [NB100-317] - Increased levels of IFI16 protein in WI-38 cells reduce hTERT levels and inhibit telomerase activity. Total protein extracts prepared from WI-38 cells, either transfected with control (pCMV) vector (lane 1) or pCMV-IFI16 plasmid (lane 2), were subjected to immunoblotting using antibodies specific to the indicated proteins. Image collected and cropped by CiteAb from the following publication (http://dx.plos.org/10.1371/journal.pone.0008569), licensed under a CC-BY licence.Immunohistochemistry-Paraffin: TERT Antibody (2C4) [NB100-317] - Human Pancreatic carcinoma showing strong staining of tumor cells.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, Flow, ICC/IF

22 Publications
NB200-103
Western Blot: p53 Antibody (PAb 240) [NB200-103] - Analysis of p53 in MCF7 and HeLa lystates. Image courtesy of anonymous customer product review.Immunocytochemistry/Immunofluorescence: p53 Antibody (PAb 240) [NB200-103] - PC12 cells were fixed in 4% paraformaldehyde for 10 minutes and permeabilized in 0.5% Triton X-100 in PBS for 5 minutes. The cells were incubated with anti-p53 Antibody (PAb 240) NB200-103 at 2 ug/ml overnight at 4C and detected with an anti-mouse Dylight 488 (Green) at a 1:1000 dilution for 60 minutes. Nuclei were counterstained with DAPI (Blue).  Cells were imaged using a 40X objective.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, Flow

     3 Reviews

33 Publications
H00004354-M01
Western Blot: MPP1 Antibody (1E11-1G11) [H00004354-M01] - Analysis of MPP1 expression in transfected 293T cell line by MPP1 monoclonal antibody (M01), clone 1E11-1G11.Lane 1: MPP1 transfected lysate (Predicted MW: 52.3 KDa).Lane 2: Non-transfected lysate.Immunocytochemistry/Immunofluorescence: MPP1 Antibody (1E11-1G11) [H00004354-M01] - Analysis of monoclonal antibody to MPP1 on HeLa cell. Antibody concentration 10 ug/ml.

Mouse Monoclonal
Species Human
Applications WB, ELISA, ICC/IF

1 Publication
NB100-56183
Western Blot: XIAP Antibody - Unpurified [NB100-56183] - Analysis of XIAP in various tumor cell lines using this antibody at 1:2000.Immunocytochemistry/Immunofluorescence: XIAP Antibody [NB100-56183] - Immunocytochemistry for XIAP expression levels in IMR32 cells (Scale bar: 67 um). Image collected and cropped by CiteAb from the following publication (https://www.nature.com/articles/s41598-018-20499-7/figures/7) licensed under a CC-BY licence.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

     2 Reviews

5 Publications
NB110-92756
Western Blot: APCDD1 Antibody [NB110-92756] - Detection of APCDD1 in human heart lysate

Rabbit Polyclonal
Species Human, Mouse, Chicken
Applications WB

1 Publication
NB100-68252
Western Blot: WDR79 Antibody [NB100-68252] - Depletion of WDR79 (TCAB1) reduced the cell proliferation in vitro. Protein level also significantly decreased after shWDR79 (TCAB1) lentivirus treatment. Image collected and cropped by CiteAb from the following publication (http://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-13-180), licensed under a CC-BY licence.Immunohistochemistry: WDR79 Antibody [NB100-68252] - WDR79 (TCAB1) was overexpressed in cell lines and in tissues of head and neck cancers. The typical IHC results (Left: WDR79 (TCAB1) positive, Right: WDR79 (TCAB1) negative) of WDR79 (TCAB1) in human NPC and Npi. Image collected and cropped by CiteAb from the following publication (http://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-13-180), licensed under a CC-BY licence.

Rabbit Polyclonal
Species Human
Applications WB, ChIP, ICC/IF

     1 Review

8 Publications
NBP2-01764
Western Blot: RUVBL2 Antibody (1A6) [NBP2-01764] -  Analysis of extracts (10ug) from 9 Human tissue by using anti-RUVBL2 monoclonal antibody at 1:200 (1: Testis; 2: Omentum; 3: Uterus; 4: Breast; 5: Brain; 6: Liver; 7: Ovary; 8: Thyroid gland; 9: colon).Immunocytochemistry/Immunofluorescence: RUVBL2 Antibody (1A6) [NBP2-01764] - Staining of COS7 cells transiently transfected by pCMV6-ENTRY RUVBL2.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, Flow, ICC/IF

1 Publication
NBP1-89306
Western Blot: TNIP1 Antibody [NBP1-89306] - Analysis in U-87MG ATCC cells transfected with control siRNA, target specific siRNA probe #1 and #2,. Remaining relative intensity is presented. Loading control: Anti-GAPDH.Western Blot: TNIP1 Antibody [NBP1-89306] - Analysis using Anti-TNIP1 antibody NBP1-89306 (A) shows similar pattern to independent antibody NBP2-32705 (B).

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC, IHC-P

NBP2-47560
Immunohistochemistry-Paraffin: 26S proteasome subunit 9 Antibody [NBP2-47560] - Staining of human kidney, liver, skin and testis using Anti-PSMD9 antibody NBP2-47560 (A) shows similar protein distribution across tissues to independent antibody NBP2-47561 (B).Western Blot: 26S proteasome subunit 9 Antibody [NBP2-47560] - Lane 1: Marker  [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10.  Lane 2: Human cell line MCF-7

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

NBP1-84745
Immunohistochemistry-Paraffin: IFI27 Antibody [NBP1-84745] - Staining of human liver shows no positivity in hepatocytes as Expected.Immunohistochemistry-Paraffin: IFI27 Antibody [NBP1-84745] - Staining of human stomach shows strong granular cytoplasmic positivity in glandular cells.

Rabbit Polyclonal
Species Human
Applications IHC, IHC-P

2 Publications
AF7174
<P align=left>Western blot shows lysates of COLO 205 human colorectal adenocarcinoma cell line, MCF‑7 human breast cancer cell line, and mouse testis tissue. PVDF membrane was probed with 0.5 µg/mL of Sheep Anti-Human Polypeptide GalNac Transferase 3/GALNT3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7174) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # <A class=NoLineLink href=<P align=left>Polypeptide GalNac Transferase 3/GALNT3 was detected in immersion fixed HeLa human cervical epithelial carcinoma cell line using Sheep Anti-Human Polypeptide GalNac Transferase 3/GALNT3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7174) at 15 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Sheep IgG Secondary Antibody (red; Catalog # <A class=NoLineLink href=

Sheep Polyclonal
Species Human
Applications WB, ICC

NBP2-49230
Western Blot: Synaptic glycoprotein SC2 Antibody [NBP2-49230] - Analysis in control (vector only transfected HEK293T lysate) and TECR over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).Immunocytochemistry/Immunofluorescence: Synaptic glycoprotein SC2 Antibody [NBP2-49230] - Immunofluorescent staining of human cell line U-251 MG shows localization to endoplasmic reticulum.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

NBP1-90949
Western Blot: TMED7 Antibody [NBP1-90949] - Analysis in human cell line CAPAN-2.Immunohistochemistry-Paraffin: TMED7 Antibody [NBP1-90949] - Staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

1 Publication
NBP1-80866
Western Blot: TRUB1 Antibody [NBP1-80866] - Analysis in control (vector only transfected HEK293T lysate) and TRUB1 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).Immunocytochemistry/Immunofluorescence: TRUB1 Antibody [NBP1-80866] - Staining of human cell line U-2 OS shows localization to actin filaments. Antibody staining is shown in green.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC


Related Genes

X-linked Dyskeratosis Congenita has been researched against:

Related PTMs

X-linked Dyskeratosis Congenita has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

X-linked Dyskeratosis Congenita is also known as Zinsser-cole-engman Syndrome.