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Vitamin B 12 Deficiency: Disease Bioinformatics

Low levels of Vitamin B12 know as Vitamin B12 deficiency typically occurs in people that cannot absorb the vitamin correctly from the foods they eat. Vitamin B12 is essential to make red blood cells, as well as your body’s genetic material and keeps amino acid and homocysteine levels in check. Symptoms of Vitamin B12 deficiency are: weakness, tiredness, rapid heartbeat or breathing, sore tongue and pale skin. If Vitamin B12 deficiency goes untreated it can damage nerve cells which leads to more serious problems.

Vitamin B 12 Deficiency Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Vitamin B 12 Deficiency below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 2458 products for the study of Vitamin B 12 Deficiency that can be applied to Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

CBS Antibody (3E1)
H00000875-M01
Western Blot: CBS Antibody (3E1) [H00000875-M01] - Analysis of CBS expression in transfected 293T cell line by CBS monoclonal antibody (M01), clone 3E1.Lane 1: CBS transfected lysate(61 KDa).Lane 2: Non-transfected lysate.Immunohistochemistry-Paraffin: CBS Antibody (3E1) [H00000875-M01] - Analysis of monoclonal antibody to CBS on formalin-fixed paraffin-embedded human hepatocellular carcinoma. Antibody concentration 3 ug/ml.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, ICC/IF

     1 Review

53 Publications
GIF Antibody
NBP1-81610
Immunohistochemistry-Paraffin: GIF Antibody [NBP1-81610] - Analysis in human stomach and skin tissues. Corresponding GIF RNA-seq data are presented for the same tissues.Western Blot: GIF Antibody [NBP1-81610] - Analysis in control (vector only transfected HEK293T lysate) and GIF over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

     1 Review

Cubilin Antibody [Unconjugated]
AF3700
Western blot shows lysates of human, mouse, and rat kidney tissue. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human/Mouse/<br>Rat Cubilin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3700) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # <a class= Cubilin was detected in immersion fixed paraffin-embedded sections of human kidney tissue using Sheep Anti-Human/Mouse/Rat Cubilin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3700) at 1 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # <a class=

Sheep Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, IHC

     1 Review

4 Publications
Transcobalamin II Antibody
AF7895
Western blot shows lysates of HUVEC human umbilical vein endothelial cells and RPMI 8226 human multiple myeloma cell line. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human/Mouse/Rat Transcobalamin II Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7895) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # <A class=NoLineLink href=Transcobalamin II was detected in immersion fixed paraffin-embedded sections of human kidney using Sheep Anti-Human/Mouse/Rat Transcobalamin II Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7895) at 10 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # <a class=

Sheep Polyclonal
Species Human
Applications WB, IHC

Insulin Antibody (182410) [Unconjugated]
MAB1417
Insulin was detected in immersion fixed beta TC‑6 mouse beta cell insulinoma cell line using Human/Mouse/Bovine Insulin Monoclonal Antibody (Catalog # MAB1417) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Rat IgG Secondary Antibody (red; Catalog # <A class=NoLineLink href=Insulin was detected in immersion fixed paraffin-embedded sections of human pancreas using Rat Anti-Human/Mouse/Bovine Insulin Monoclonal Antibody (Catalog # MAB1417) at 0.5 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Rat IgG VisUCyte™ HRP Polymer Antibody (<a class=

Rat Monoclonal
Species Human, Mouse, Bovine
Applications IHC, CyTOF-ready, ICC

15 Publications
Albumin Antibody (188835) [Unconjugated] - Serum
MAB1455
Western blot shows lysate of human liver tissue. PVDF membrane was probed with 1 µg/mL of Mouse Anti-Human Serum Albumin Monoclonal Antibody (Catalog # MAB1455) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # <a class=Albumin was detected in immersion fixed BG01V human embryonic stem cells differentiated to hepatocytes using Mouse Anti-Human Serum Albumin Monoclonal Antibody (Catalog # MAB1455) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # <a class=

Mouse Monoclonal
Species Human
Applications WB, Simple Western, IHC

     3 Reviews

32 Publications
CBL Antibody (3B12)
NBP2-37574
Western Blot: CBL Antibody (3B12) [NBP2-37574] - Western blot analysis using C-CBL mouse mAb against RAJI (1), RAW264.7 (2), K562 (3), SKBR-3 (4), 3T3-L1 (5), THP-1 (6) and PC-12 (7) cell lysate.Immunocytochemistry/Immunofluorescence: CBL Antibody (3B12) [NBP2-37574] - Immunofluorescence analysis of Hela cells using C-CBL mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, Flow

     1 Review

MTHFR Antibody (5D3)
NBP2-37607
Western Blot: MTHFR Antibody (5D3) [NBP2-37607] - Western blot analysis using MTHFR mouse mAb against Rat Heart cell lysate.Immunohistochemistry-Paraffin: MTHFR Antibody (5D3) [NBP2-37607] - Analysis of intima cancer tissues (left) and prostate tissues (right) using MTHFR mouse mAb with DAB staining.

Mouse Monoclonal
Species Human, Rat
Applications WB, ELISA, IHC

Erythropoietin/EPO [HRP]
MEP00B
Erythropoietin/EPO [HRP] Erythropoietin/EPO [HRP]


Species Mouse
Applications ELISA

99 Publications
Holo-Transferrin [Unconjugated]
2914-HT


Species Human
Applications BA

41 Publications
TNF-alpha [Unconjugated]
210-TA
Recombinant Human TNF-alpha (Catalog # 210-TA) has a molecular weight (MW) of 53.1 kDa as analyzed by SEC-MALS, suggesting that this protein is a homotrimer.  MW may differ from predicted MW due to post-translational modifications (PTMs) present (i.e. Glycosylation).Recombinant Human TNF-alpha (Catalog # 210‑TA) induces cytotoxicity in the L-929 mouse fibroblast cell line in the presence of the metabolic inhibitor actinomycin D. The ED<sub>50</sub> for this effect is 25‑100 pg/mL.


Species Human
Applications BA

     3 Reviews

774 Publications
EGF [Unconjugated]
236-EG
Recombinant Human EGF (Catalog # 236‑EG) stimulates cell proliferation of the Balb/3T3 mouse embryonic fibroblast cell line. The ED<sub>50</sub> for this effect is 20‑100 pg/mL.1 µg/lane of Recombinant Human EGF was resolved with SDS-PAGE  and visualized by silver staining under reducing (R) conditions, showing a single band at 6 kDa.


Species Human
Applications BA

724 Publications
GM-CSF [Unconjugated]
7954-GM/CF
Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED<sub>50</sub> for this effect is 6-30 pg/mL.


Species Human
Applications BA

3 Publications
LAMC2 Antibody (CL2980)
NBP2-42388
Immunohistochemistry-Paraffin: LAMC2 Antibody (CL2980) [NBP2-42388] - Staining in human fallopian tube and liver tissues. Corresponding LAMC2 RNA-seq data are presented for the same tissues.Western Blot: LAMC2 Antibody (CL2980) [NBP2-42388] - Analysis in A-431 cells transfected with control siRNA, target specific siRNA probe #1 and #2, using Anti-LAMC2 antibody. Remaining relative intensity is presented. Loading control: Anti-GAPDH.

Mouse Monoclonal
Species Human
Applications WB, ICC/IF, IHC

4 Publications
MTR Antibody
NB100-791
Western Blot: MTR Antibody [NB100-791] - Cgl null mice exhibit female-specific alteration of enzymes involved in the remethylation of methionine. Western blotting analysis of hepatic BHMT, MTHFR and MTR protein expression levels in male and female WT and Cgl null mice. Values shown represent the mean+-s.d., *Pless than 0.05, **Pless than 0.01, ***Pless than 0.001. Image collected and cropped by CiteAb from the following publication (//bio.biologists.org/cgi/doi/10.1242/bio.013433) licensed under a CC-BY license.Immunohistochemistry-Paraffin: MTR Antibody [NB100-791] - Human adrenal gland. Antibody at 3.8 ug/mL. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Goat Polyclonal
Species Human, Mouse
Applications WB, IHC, IHC-P

     2 Reviews

3 Publications
TNFAIP1 Antibody - BSA Free
NBP2-82039
Western Blot: TNFAIP1 Antibody [NBP2-82039] - Western blot analysis of TNFAIP1 in mouse brain tissue lysate with TNFAIP1 antibody at 1 ug/ml.Immunocytochemistry/Immunofluorescence: TNFAIP1 Antibody [NBP2-82039] - Immunofluorescence of TNFAIP1 in mouse brain tissue with TNFAIP1 antibody at 20 ug/ml. Red: TNFAIP1 Antibody (NBP2-82039). Blue: DAPI staining.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ELISA, ICC/IF

NDUFB3 Antibody
NBP2-93366
Western Blot: NDUFB3 Antibody [NBP2-93366] - Analysis of extracts of various cell lines, using NDUFB3 at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit .Exposure time: 10s.Immunocytochemistry/Immunofluorescence: NDUFB3 Antibody [NBP2-93366] - Analysis of L929 cells using NDUFB3 . Blue: DAPI for nuclear staining.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ICC/IF

Thymidylate Synthase Antibody (TYMS/1884) - Azide and BSA Free
NBP3-08882
Western Blot: Thymidylate Synthase Antibody (TYMS/1884) [NBP3-08882] - Western Blot Analysis of human HeLa cell lysate using Thymidylate Synthase Mouse Monoclonal Antibody (TYMS/1884).Immunocytochemistry/Immunofluorescence: Thymidylate Synthase Antibody (TYMS/1884) [NBP3-08882] - Immunofluorescence Analysis of PFA-fixed Ramos cells labeling PU.1 with Thymidylate Synthase Mouse Monoclonal Antibody (TYMS/1884) followed by goat anti- Mouse IgG-CF488 (Green). Membrane is labeled with Phalloidin (Red).

Mouse Monoclonal
Species Human
Applications WB, Flow, ICC/IF

Gastrin Antibody
NBP3-12223
Immunohistochemistry-Paraffin: Gastrin Antibody [NBP3-12223] - Rat stomach-gastrin-1:50 dilution in IHC blocking buffer. DAB (brown) staining and hematoxylin QS (blue) counterstain. 10X and 20X magnification on Leica DM4000. Gastrin Antibody [NBP3-12223] - Rat stomach-gastrin-1:50 dilution in IHC blocking buffer. DAB (brown) staining and hematoxylin QS (blue) counterstain. 10X and 20X magnification on Leica DM4000.

Rabbit Polyclonal
Species Human, Rat, Primate
Applications WB, ELISA, ICC/IF


Related Genes

Vitamin B 12 Deficiency has been researched against:

Related Pathways

Vitamin B 12 Deficiency has been linked to:

Related Diseases

Vitamin B 12 Deficiency has been studied in relation to diseases such as:

Related PTMs

Vitamin B 12 Deficiency has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Vitamin B 12 Deficiency is also known as Cobalamin Deficiency, Cyanocobalamin Deficiency, Deficiency Of Vitamin B12, Deficiency, Vitamin B12, Vitamin B12 Deficiencies.