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Twiddler's Syndrome: Disease Bioinformatics

Twiddler's Syndrome is a rare condition in which patients subconsciously or purposefully manipulate their pacemaker, causing the leads to dislodge and the device to fail. Disturbances in the conduction of the pacemaker, depending on where the leads moved within the body, could affect the diaphragm, pectoral muscles, or brachial plexus, and could lead to sudden cardiac arrest. Twidder's Syndrome can also cause the failure of implantable cardioverter-defibrillator (ICD) devices. Twiddler's Syndrome can be treated surgically be reattaching the leads of the device and suturing the device into a smaller pocket within the body.

Twiddler's Syndrome Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Twiddler's Syndrome below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 144 products for the study of Twiddler's Syndrome that can be applied to Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Chromatin Immunoprecipitation (ChIP) from our catalog of antibodies and ELISA kits.

Immunohistochemistry-Paraffin: KIF7 Antibody [NBP1-92056] - Immunohistochemical staining of human placenta shows strong cytoplasmic positivity in trophoblastic cells.

Rabbit Polyclonal
Species Human
Applications IHC, IHC-P

Western blot shows lysates of mouse embryo tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse GLI‑3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3690) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <A class=NoLineLink href=Jurkat human acute T cell leukemia cell line treated with 50 ng/mL PMA and 200 ng/mL calcium ionomycin for 30 minutes was fixed using formaldehyde, resuspended in lysis buffer, and sonicated to shear chromatin. GLI‑3/DNA complexes were immunoprecipitated using 5 μg Goat Anti-Human/Mouse GLI‑3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3690) or control antibody (Catalog # <A class=NoLineLink href=

Goat Polyclonal
Species Human, Mouse
Applications WB, ChIP, ICC

     4 Reviews

8 Publications
Immunohistochemistry-Paraffin: MCF2L Antibody (1D11) [H00023263-M01] - Analysis of monoclonal antibody to MCF2L on formalin-fixed paraffin-embedded human tonsil. Antibody concentration 1 ug/ml.Sandwich ELISA: MCF2L Antibody (1D11) [H00023263-M01] - Detection limit for recombinant GST tagged MCF2L is approximately 0.03ng/ml as a capture antibody.

Mouse Monoclonal
Species Human
Applications WB, ELISA, IHC

Western Blot: Cytokeratin 5 Antibody (2C2) [NBP2-22194] - Western blot analysis using Cytokeratin 5 mouse mAb against A431 (1), MCF-7 (2), HeLa (3), HepG2 (4), 3T3-L1 (5), and COS-7 (6) cell lysate.Immunocytochemistry/Immunofluorescence: Cytokeratin 5 Antibody (2C2) [NBP2-22194] - Immunofluorescence analysis of HeLa  cells. Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.

Mouse Monoclonal
Species Human, Mouse, Monkey
Applications WB, ELISA, Flow

Immunocytochemistry/Immunofluorescence: LRP2 Antibody (CD7D5) [NB110-96417] -  Immunofluorescence staining of Megalin in the brush border of the proximal tubule.Immunohistochemistry-Paraffin: LRP2 Antibody (CD7D5) [NB110-96417] -  Staining (paraffin-embedded tissue-sections fixed in formalin) of Megalin in the brush border of the proximal tubule.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications ICC/IF, IHC, IHC-Fr

     1 Review

6 Publications

Related Genes

Twiddler's Syndrome has been researched against:

Related Pathways

Related PTMs

Alternate Names

Twiddler's Syndrome is also known as Twiddlers Syndrome.