Toxic epidermal necrolysis is an extremely rare condition also called Lyell’s syndrome, is considered a more severe form of Stevens-Johnson syndrome. Toxic epidermal necrolysis is a severely adverse reaction to certain medications where the epidermis detaches from the dermis all over the body and there between.4 and 1.3 per million reported cases each year. Toxic epidermal necrolysis can affect anyone but a history of medication use exists in over 95% of patients with toxic epidermal necrolysis. This condition can be fatal and between 30% and 40% of cases lead to mortality. And if a patient survives toxic epidermal necrolysis, long-term complications include blindness, and skin manifestations such as scarring and eruptive melanocytic nevi. Treatment of toxic epidermal necrolysis include withdrawal of the culprit drugs and referral to intensive-care units, Intravenous immunoglobulin, and cyclosporin however if the condition is not caught early enough, patients lose too much skin and often contract sepsis or some type of respiratory disease.
Toxic Epidermal Necrolysis Bioinformatics Tool
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