Tay-Sachs disease is a rare inherited disorder that progressively destroys neurons in the brain and spinal cord which typically begins during infancy. Tay-Sachs disease is caused by a mutation in the HEXA gene and it is inherited in an autosomal recessive pattern. Tay-Sachs disease is also called Gangliosidosis (GM2) type 1 or Hexosaminidase A deficiency and only 1 in 300 people is a carrier for Tay-Sachs disease. There is no cure for Tay-Sachs disease, however, treatment includes targeting and controlling some of the symptoms - such as providing anticonvulsants to control seizures and proper nutrition and hydration and other comfort measures. Age of death for infants who contract Tay-Sachs disease in typically between 2 and 4 years. Tay-Sachs disease is rare in the general population and the genetic mutations that cause this disease are more common in people of Ashkenazi (eastern and central European) Jewish heritage than in those with other backgrounds.
Tay-sachs Disease Bioinformatics Tool
Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Tay-sachs Disease below!
For more information on how to use Laverne, please read the How to Guide.
We have 1462 products for the study of Tay-sachs Disease that can be applied to Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.
![Western Blot: Arylsulfatase A/ARSA Antibody [NBP1-00154] - Western blot analysis of Mouse testes lysate (A) + peptide (B) with antibody at 1 ug/mL and Rat testes lysate (C) + peptide (D) with antibody at 0.3 ug/mL, 35ug protein in RIPA buffer. Detected by chemiluminescence.](https://images.novusbio.com/fullsize2/Arylsulfatase-A-ARSA-Antibody-Western-Blot-NBP1-00154-img0006.jpg)
![Immunocytochemistry/Immunofluorescence: Arylsulfatase A/ARSA Antibody [NBP1-00154] - Immunofluorescence analysis of paraformaldehyde fixed HeLa cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (2 ug/mL), showing Golgi apparatus staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (2 ug/mL).](https://images.novusbio.com/fullsize2/Arylsulfatase-A-ARSA-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-00154-img0007.jpg)
![Western Blot: Aromatase Antibody [NB100-1596] - Expression of the cytochrome P450 aromatase in the ovary of control (C; open bar; n = 6) and hypothyroid (Hypo; solid bar; n = 6) rabbits. Representative immunoblot showing the expression of aromatase. Image collected and cropped by CiteAb from the following publication (https://www.hindawi.com/journals/bmri/2017/3795950/), licensed under a CC-BY licence.](https://images.novusbio.com/fullsize2/Aromatase-Antibody-Western-Blot-NB100-1596-img0005.jpg)
![Immunocytochemistry/Immunofluorescence: Aromatase Antibody [NB100-1596] - U2OS cells were fixed in 4% paraformaldehyde for 10 minutes and permeabilized in 0.05% Triton X-100 in PBS for 5 minutes. The cells were incubated with anti-Aromatase Antibody NB100-1596 at 2 ug/ml overnight at 4C and detected with an anti-rabbit Dylight 488 (Green) at a 1:1000 dilution for 60 minutes. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 100X objective and digitally deconvolved.](https://images.novusbio.com/fullsize2/Aromatase-Antibody-Immunocytochemistry-Immunofluorescence-NB100-1596-img0008.jpg)
![Western Blot: MS4A1/CD20 Antibody (AISB12) [NBP1-43435] - Immunoblot of Balb/c thymus (lane 1) and A20 (lane 2) cell lysates with Anti-Mouse CD20 Purified.](https://images.novusbio.com/fullsize2/MS4A1-CD20-Antibody-(AISB12)-Western-Blot-NBP1-43435-img0002.jpg)
![Flow Cytometry: MS4A1/CD20 Antibody (AISB12) [NBP1-43435] - Staining of BALB/c splenocytes with Anti-Mouse CD19 Alexa Fluor (R) 647 and 1.0 micrograms conjugated anti-Mouse CD20 Purified followed by Anti-Rat IgG PE. Quadrant lines represent Rat IgG2a isotype control staining levels and cells in the lymphocyte gate were used for analysis.](https://images.novusbio.com/fullsize2/MS4A1-CD20-Antibody-(AISB12)-Flow-Cytometry-NBP1-43435-img0004.jpg)
![Immunohistochemistry-Paraffin: Glutaminyl-peptide Cyclotransferase/QPCT Antibody [NBP1-81838] - Staining in human adrenal gland and liver tissues using anti-QPCT antibody. Corresponding QPCT RNA-seq data are presented for the same tissues.](https://images.novusbio.com/fullsize2/Glutaminyl-peptide-Cyclotransferase-QPCT-Antibody-Immunohistochemistry-Paraffin-NBP1-81838-img0010.jpg)
![Western Blot: Glutaminyl-peptide Cyclotransferase/QPCT Antibody [NBP1-81838] - Analysis in control (vector only transfected HEK293T lysate) and QPCT over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).](https://images.novusbio.com/fullsize2/Glutaminyl-peptide-Cyclotransferase-QPCT-Antibody-Western-Blot-NBP1-81838-img0011.jpg)
![Western Blot: HEXDC Antibody [NBP1-83575] - Analysis in human cell line HEK 293.](https://images.novusbio.com/fullsize2/HEXDC-Antibody-Western-Blot-NBP1-83575-img0005.jpg)
![Immunohistochemistry-Paraffin: HEXDC Antibody [NBP1-83575] - Staining of human lymph node shows no positivity in non-germinal center cells as expected.](https://images.novusbio.com/fullsize2/HEXDC-Antibody-Immunohistochemistry-Paraffin-NBP1-83575-img0004.jpg)
![Immunohistochemistry-Paraffin: DMRT1 Antibody [NBP1-84071] - Staining in human testis and fallopian tube tissues using anti-DMRT1 antibody. Corresponding DMRT1 RNA-seq data are presented for the same tissues.](https://images.novusbio.com/fullsize2/DMRT1-Antibody-Immunohistochemistry-Paraffin-NBP1-84071-img0010.jpg)
![Western Blot: DMRT1 Antibody [NBP1-84071] - Analysis in control (vector only transfected HEK293T lysate) and DMRT1 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).](https://images.novusbio.com/fullsize2/DMRT1-Antibody-Western-Blot-NBP1-84071-img0007.jpg)
![Immunohistochemistry-Paraffin: BBS9 Antibody [NBP1-88927] - Staining of human cerebellum shows strong cytoplasmic positivity in purkinje cells.](https://images.novusbio.com/fullsize2/BBS9-Antibody-Immunohistochemistry-Paraffin-NBP1-88927-img0002.jpg)
![Western Blot: RanGAP1 Antibody (1B4) [NBP2-02623] Analysis of extracts (35ug) from 9 different cell lines by using anti-RanGAP1 monoclonal antibody.](https://images.novusbio.com/fullsize/RanGAP1-Antibody-(1B4)-Western-Blot-NBP2-02623-img0009.jpg)
![Immunocytochemistry/Immunofluorescence: RanGAP1 Antibody (1B4) [NBP2-02623] - Staining of COS7 cells transiently transfected by pCMV6-ENTRY RanGAP1.](https://images.novusbio.com/fullsize/RanGAP1-Antibody-(1B4)-Immunocytochemistry-Immunofluorescence-NBP2-02623-img0008.jpg)
![Western Blot: SLC17A5 Antibody [NBP2-20383] - Sample (30 ug of whole cell lysate) A: Jurkat 10% SDS PAGE gel, diluted at 1:1000.](https://images.novusbio.com/fullsize2/SLC17A5-Antibody-Western-Blot-NBP2-20383-img0001.jpg)
![Immunocytochemistry/Immunofluorescence: SLC17A5 Antibody [NBP2-20383] - Sample: HepG2 cells were fixed in -20C 100% MeOH for 5 min. Green: SLC17A5 protein stained by SLC17A5 antibody diluted at 1:500. Blue: Hoechst 33343 staining.](https://images.novusbio.com/fullsize2/SLC17A5-Antibody-Immunocytochemistry-Immunofluorescence-NBP2-20383-img0003.jpg)
![Western Blot: ETFA Antibody [NBP2-16382] - Wild-type (WT) and ETFA knockout (KO) 293T cell extracts (30 ug) were separated by 12% SDS-PAGE, and the membrane was blotted with ETFA antibody diluted at 1:1000. HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.](https://images.novusbio.com/fullsize2/ETFA-Antibody-Western-Blot-NBP2-16382-img0011.jpg)
![Immunocytochemistry/Immunofluorescence: ETFA Antibody [NBP2-16382] - Confocal immunofluorescence analysis of methanol-fixed HeLa, using ETFA antibody (Green) at 1:500 dilution. Alpha-tubulin filaments are labeled with Alpha-tubulin antibody (Red) at 1:2000.](https://images.novusbio.com/fullsize2/ETFA-Antibody-Immunocytochemistry-Immunofluorescence-NBP2-16382-img0005.jpg)
![Western Blot: beta-Galactosidase-1/GLB1 Antibody (OTI1C9) [NBP2-45731] - Analysis of extracts (35ug) from 9 different cell lines by using anti-GLB1 monoclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).](https://images.novusbio.com/fullsize2/beta-Galactosidase-1-GLB1-Antibody-(1C9)-Western-Blot-NBP2-45731-img0016.jpg)
![Immunohistochemistry: beta-Galactosidase-1/GLB1 Antibody (1C9) [NBP2-45731] - Analysis of Adenocarcinoma of Human ovary tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min)](https://images.novusbio.com/fullsize2/beta-Galactosidase-1-GLB1-Antibody-(1C9)-Immunohistochemistry-NBP2-45731-img0013.jpg)
![Western Blot: PISD Antibody (4G5) [NBP2-46421] - Analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PISD .](https://images.novusbio.com/fullsize2/PISD-Antibody-(4G5)-Western-Blot-NBP2-46421-img0004.jpg)
![Immunohistochemistry: PISD Antibody (4G5) [NBP2-46421] - Analysis of Adenocarcinoma of Human ovary tissue.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120C for 3 min)](https://images.novusbio.com/fullsize2/PISD-Antibody-(4G5)-Immunohistochemistry-NBP2-46421-img0003.jpg)
![Immunohistochemistry-Paraffin: HEXB Antibody [NBP2-49211] - Staining of human prostate shows moderate to strong granular cytoplasmic positivity in glandular cells.](https://images.novusbio.com/fullsize2/HEXB-Antibody-Immunohistochemistry-Paraffin-NBP2-49211-img0008.jpg)
![Immunohistochemistry-Paraffin: HEXB Antibody [NBP2-49211] - Staining of human epididymis shows granular cytoplasmic positivity in glandular cells.](https://images.novusbio.com/fullsize2/HEXB-Antibody-Immunohistochemistry-Paraffin-NBP2-49211-img0003.jpg)
![Western Blot: SPANXB1 Antibody [H00728695-B01P] - Analysis of SPANXB1 expression in transfected 293T cell line by SPANXB1 polyclonal antibody. Lane 1: SPANXB1 transfected lysate(11.33 KDa). Lane 2: Non-transfected lysate.](https://images.novusbio.com/fullsize2/SPANXB1-Antibody-Western-Blot-H00728695-B01P-img0004.jpg)
![Immunocytochemistry/Immunofluorescence: SPANXB1 Antibody [H00728695-B01P] - Analysis of purified antibody to SPANXB1 on Hs 181.Tes cell. (antibody concentration 10 ug/ml)](https://images.novusbio.com/fullsize2/SPANXB1-Antibody-Immunocytochemistry-Immunofluorescence-H00728695-B01P-img0003.jpg)
![Western Blot: SF-1/NR5A1/Steroidogenic Factor 1 Antibody (CL9101) [NBP2-88921] - Analysis in human cell line HEL.](https://images.novusbio.com/fullsize2/SF-1-NR5A1-Steroidogenic-Factor-1-Antibody-(CL9101)-Western-Blot-NBP2-88921-img0007.jpg)
![Immunocytochemistry/Immunofluorescence: SF-1/NR5A1/Steroidogenic Factor 1 Antibody (CL9101) [NBP2-88921] - Staining of U-2 OS cells using the Anti-NR5A1 monoclonal antibody, showing specific staining in the nucleoplasm in green. Microtubule- and nuclear probes are visualized in red and blue, respectively (where available).](https://images.novusbio.com/fullsize2/SF-1-NR5A1-Steroidogenic-Factor-1-Antibody-(CL9101)-Immunocytochemistry-Immunofluorescence-NBP2-88921-img0001.jpg)
