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Stage Ii Colorectal Cancer: Disease Bioinformatics

Colorectal cancer, commonly referred to as colon cancer, originates in the colon (large intestine) or rectum, typically as adenomatous polyps. It is unknown what causes cancer yet familial adenomatous polposis (FAP) and hereditary nonpolyposis colorectal cancer (HNPCC) are thought to increase risk of developing colon cancer. Additionally, increasing age, inflammatory intestinal conditions, nationality, low fiber and high fat diet, diabetes, smoking, alcohol, obesity, and a sedentary lifestyle can contribute to its onset. Treatments for colon cancer include surgery, chemotherapy, radiation therapy, and targeted drug therapy. Stage II colon cancer can be separated into stage IIA, IIB, and IIC. In Stage IIA, the cancer has grown through the muscle layer of the colon wall into the serosa (outer layer). Stage IIB occurs when the colon has developed through the serosa but has not spread to nearby organs. A diagnosis of stage IIC is when the cancer has grown onto nearby organs. At this point, the cancer has not spread to distant locations.

Stage Ii Colorectal Cancer Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Stage Ii Colorectal Cancer below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 3035 products for the study of Stage Ii Colorectal Cancer that can be applied to Chromatin Immunoprecipitation (ChIP), Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

H00003845-M01
Western Blot: KRAS Antibody (3B10-2F2) [H00003845-M01] - Western blot analysis of KRAS expression in lysates from human lung cancer cell lines: H23, H358, A549, and H441. Image from verified customer review.Western Blot: KRAS Antibody (3B10-2F2) [H00003845-M01] - Western Blot analysis of KRAS expression in transfected 293T cell line by KRAS monoclonal antibody (M01), clone 3B10-2F2.<br><br>Lane 1: KRAS transfected lysate(21 KDa).<br>Lane 2: Non-transfected lysate.<br>

Mouse Monoclonal
Species Human, Mouse
Applications WB, ELISA, ICC/IF

     1 Review

17 Publications
NB100-687
Simple Western: Cytokeratin 19 Antibody [NB100-687] - Lane view shows a specific band for Cytokeratin 19 in 0.5 mg/ml of HepG2 lysate.  This experiment was performed under standard reducing conditions using the 12-230 kDa separation system.Western Blot: Cytokeratin 19 Antibody [NB100-687] - Western blot detection of YAP and TAZ in proteins extracted from isolated hepatocytes and cholangiocytes and total liver tissue. Antibodies against CK19 and HNF4a were used to confirm purity of the populations and b-actin was used as a loading control. Representative results from a single experiment with n = 3 independent cell isolations and n = 2 total liver tissues. Image collected and cropped by CiteAb from the following publication(http://embomolmed.embopress.org/lookup/doi/10.15252/emmm.201506089), licensed under a CC-BY license.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, Flow

     1 Review

8 Publications
NBP1-85599
Immunohistochemistry-Paraffin: Cytokeratin 20 Antibody [NBP1-85599] - Analysis in human small intestine and liver tissues.  Corresponding KRT20 RNA-seq data are presented for the same tissues.Western Blot: Cytokeratin 20 Antibody [NBP1-85599] - Analysis in human small intestine tissue.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, IHC, IHC-P

2 Publications
NB200-103
Western Blot: p53 Antibody (PAb 240) [NB200-103] - Analysis of p53 in MCF7 and HeLa lystates. Image courtesy of anonymous customer product review.Immunocytochemistry/Immunofluorescence: p53 Antibody (PAb 240) [NB200-103] - PC12 cells were fixed in 4% paraformaldehyde for 10 minutes and permeabilized in 0.5% Triton X-100 in PBS for 5 minutes. The cells were incubated with anti-p53 Antibody (PAb 240) NB200-103 at 2 ug/ml overnight at 4C and detected with an anti-mouse Dylight 488 (Green) at a 1:1000 dilution for 60 minutes. Nuclei were counterstained with DAPI (Blue).  Cells were imaged using a 40X objective.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, Flow

     3 Reviews

36 Publications
NB100-689
Immunohistochemistry-Paraffin: COX-2 Antibody [NB100-689] - Formalin fixed paraffin embedded colon carcinoma stained with COX-2 antibody (NB100-689).Simple Western: COX-2 Antibody [NB100-689] - Simple Western lane view shows a specific band for COX2 in 1.0 mg/ml of Rat Brain at an antibody concentration of 1:100.  This experiment was performed under reducing conditions using the 12-230 kDa separation system.  Image provided through customer review.

Rabbit Polyclonal
Species Human, Rat
Applications WB, Simple Western, IHC

     1 Review

34 Publications
NBP2-24875
Flow Cytometry: TLR3 Antibody (40C1285.6) [NBP2-24875] - Expression of TLR3 protein on epithelial cells. HNEC (A), Detroit-562 (B) and FaDu (C) were stained intracellularly with FITC-Abs against TLR3 (open histograms) or appropriate isotype control (shaded histograms) and analyzed by flow cytometry. Representative pictures from one out of three independent experiments are shown. Image collected and cropped by CiteAb from the following publication (//dx.plos.org/10.1371/journal.pone.0098239), licensed under a CC-BY license.Western Blot: TLR3 Antibody (40C1285.6) [NBP2-24875] - All the cell lines displayed a strong expression of TLR3 protein. Cell lysates were electrophoresed and blotted to PVDF membrane, which was probed with TLR3-specific antibody. To confirm the immunoreactivity of the antibody, different positive controls were included. Beta-actin was served as loading control and was used to normalize expression levels between cells. Data are representative for analysis of >=2 independent experiments. Image collected and cropped by CiteAb from the following publication (//doi.org/10.1371/journal.pone.0060671) licensed under a CC-BY license.

Mouse Monoclonal
Species Human, Mouse, Canine
Applications WB, Flow, ICC/IF

86 Publications
AF844
DCC was detected in immersion fixed paraffin-embedded sections of Mouse Embryo Developing Brain using Goat Anti-Mouse DCC Antigen Affinity-purified Polyclonal Antibody (Catalog # AF844) at 15 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (Catalog # <a class=NoLineLink href=

Goat Polyclonal
Species Mouse
Applications WB, IHC, Block

     1 Review

7 Publications
AF1356
CD117/c-kit was detected in immersion fixed frozen sections of mouse embryo using Goat Anti-Human/Mouse CD117/c-kit Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1356) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # <a class=Western blot shows lysates of MO7e human megakaryocytic leukemic cell line, P815 mouse mastocytoma cell line, and MC/9‑2 mouse mast cell line. PVDF membrane was probed with 0.1 µg/mL of Goat Anti-Human/Mouse CD117/c-kit Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1356) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <A class=NoLineLink href=

Goat Polyclonal
Species Human, Mouse
Applications WB, Simple Western, Flow

     4 Reviews

52 Publications
NBP2-42864
Western Blot: HRAS Antibody [NBP2-42864] - Various whole cell extracts (30 ug) were separated by 12% SDS-PAGE, and the membrane was blotted with H-RAS antibody diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (NBP2-19301) was used to detect the primary antibody.Immunocytochemistry/Immunofluorescence: HRAS Antibody [NBP2-42864] - Analysis of paraformaldehyde-fixed HeLa, using H-Ras antibody at 1:200 dilution.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

2 Publications
MAB44782
HEK293 human embryonic kidney cell line transfected with human CEACAM-7 and eGFP was stained with either (A) Mouse Anti-Human CEACAM‑7 Monoclonal Antibody (Catalog # MAB44782) or (B) Mouse IgG1 Isotype Control(Catalog # <a class=    CEACAM‑7  was detected in immersion fixed paraffin-embedded sections of human colon  cancer tissue using Mouse Anti-Human CEACAM‑7 Monoclonal Antibody  (Catalog # MAB44782) at 5 µg/mL for 1 hour at room  temperature followed by incubation with the Anti-Mouse IgG  VisUCyte™  HRP Polymer  Antibody (Catalog # <a class=

Mouse Monoclonal
Species Human
Applications ELISA, Flow, IHC

1 Publication
NB100-464
Western Blot: Chk1 Antibody [NB100-464] - Knockout of ORC2 in HCT116 p53-/- cells. Western blot of ORC2 in HBEC and 293T cell lines. Ponceau S staining of total protein or immunoblot of Chk1 show equal loading of the pairs of lanes. Image collected and cropped by CiteAb from the following publication (https://elifesciences.org/articles/19084), licensed under a CC-BY license.Immunohistochemistry-Paraffin: Chk1 Antibody [NB100-464] - Section of human breast carcinoma. Antibody: Affinity purified rabbit anti-CHK1 used at a dilution of 1:1,000 (1ug/ml). Detection: DAB

Rabbit Polyclonal
Species Human, Mouse
Applications WB, IHC, IHC-P

12 Publications
MAB2157
HEK293 human embryonic kidney cell line transfected with (A) human GUCY2C or (B) irrelevant transfectants and eGFP was stained with Rabbit Anti-Human GUCY2C Monoclonal Antibody (Catalog # MAB2157) followed by APC-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # <a class=  Guanylyl  Cyclase C/GUCY2C was detected in immersion fixed LS1034 human colorectal  carcinoma cell line (positive) and HCT‑116 human colorectal  carcinoma cell line (negative) using Rabbit Anti-Human Guanylyl Cyclase  C/GUCY2C Monoclonal Antibody (Catalog # MAB2157) at  3 µg/mL for 3 hours at room temperature. Cells were  stained using the NorthernLights™ 557-conjugated Anti-Rabbit IgG  Secondary Antibody (red; Catalog # <a class=

Rabbit Monoclonal
Species Human
Applications Flow, CyTOF-ready, ICC

NBP2-34594
Immunohistochemistry-Paraffin: CEACAM5/CD66e Antibody (CEA31) - Azide and BSA Free [NBP2-34594] - Analysis of CEACAM5/CD66e antibody (CEA31) on Human Colon Carcinoma. Incubation: 1 ug/mL for 30 minutes at room temperature.Image from verified customer review.Immunohistochemistry-Paraffin: CEACAM5/CD66e Antibody (CEA31) - Azide and BSA Free [NBP2-34594] - Human Colon Carcinoma stained with CEACAM5/CD66e Antibody (CEA31).

Mouse Monoclonal
Species Human, Monkey
Applications Flow, ICC/IF, IHC

     2 Reviews


Related PTMs

Stage Ii Colorectal Cancer has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Stage Ii Colorectal Cancer is also known as Colorectal Cancer Stage Ii, Dukes B Colorectal Cancer, Dukes B Colorectal Carcinoma.