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Spastic Paraplegia, Hereditary: Disease Bioinformatics

Research of Spastic Paraplegia, Hereditary has been linked to Paraplegia, Spastic Paraplegia, Muscle Spasticity, Neurodegenerative Disorders, Paraparesis. The study of Spastic Paraplegia, Hereditary has been mentioned in research publications which can be found using our bioinformatics tool below. Researched pathways related to Spastic Paraplegia, Hereditary include Pathogenesis, Transport, Localization, Translation, Microtubule Severing. These pathways complement our catalog of research reagents for the study of Spastic Paraplegia, Hereditary including antibodies and ELISA kits against SPAST, ATL1, SPG7, SPG11, HSP90B2P.

Spastic Paraplegia, Hereditary Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Spastic Paraplegia, Hereditary below! For more information on how to use Laverne, please read the How to Guide.
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Top Research Reagents

We have 1161 products for the study of Spastic Paraplegia, Hereditary that can be applied to Chromatin Immunoprecipitation, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

NB100-1608
Immunocytochemistry/Immunofluorescence: Myelin PLP Antibody [NB100-1608] - Immunohistochemistry photomicrograph of PLP immunoreactivity (Green; 1:1000 dilution) in a cryostat section of an embryonic (e18) mouse brain. blue is DAPI nuclear counterstain.Immunohistochemistry-Frozen: Myelin PLP Antibody [NB100-1608] - Human brain and spinal cord stained with Myelin PLP antibody (green) at 1:3000 dilution.

Chicken Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

     1 Review

1 Publication
NB100-2682
Western Blot: L1CAM Antibody (UJ127.11) [NB100-2682] - SUM159 cells were exposed to 20% or 1% O2 for 48 hours, whole cell lysates were loaded with 50 ug/lane. 10% SDS-PAGE. L1CAM Antibody (NB100-2682) primary antibody: 1:1000, 4C, overnight. Western blot image submitted by a verified customer review.Immunocytochemistry/Immunofluorescence: L1CAM Antibody (UJ127.11) [NB100-2682] - The left panel (A) shows untreated Neuro2a cells and the right panel (B) shows Neuro2a cells that were serum starved then treated with 1mM cAMP overnight to induce axon growth. Cells were fixed in 4% paraformaldehyde for 10 minutes and then permeabilized for 5 minutes using 1X PBS + 0.05% Triton-X100. The cells were incubated with anti- NB100-2682 at 5 ug/ml overnight at 4C and detected with an anti-mouse Dylight 488 (Green) at a 1:1000 dilution for 60 minutes. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 100X objective and digitally deconvolved.

Mouse Monoclonal
Species Human, Mouse
Applications WB, ELISA, Flow

     2 Reviews

2 Publications
NBP1-47203
Western Blot: SPG20 Antibody [NBP1-47203] - (2ug/ml) staining of HeLa lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunocytochemistry/Immunofluorescence: SPG20 Antibody [NBP1-47203] - (2ug/ml) staining of methanol-fixed HeLa before (left) and after (right) introduction of siRNA.

Goat Polyclonal
Species Human
Applications WB, ICC/IF, PEP-ELISA

1 Publication
NBP1-76331
Western Blot: ZFYVE26 Antibody [NBP1-76331] - Analysis in K562 cell lysate with antibody at (A) 1 and (B) 2 ug/mL.Immunofluorescence: ZFYVE26 Antibody [NBP1-76331] - Mouse Heart tissue with SPG15 antibody at 20 ug/mL.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ELISA, IF

NBP1-76816
Western Blot: Kinesin 5A Antibody [NBP1-76816] - K562 cell lysate with Kinesin 5A antibody at (A) 0.5 and (B) 1 ug/ml.Immunocytochemistry/Immunofluorescence: Kinesin 5A Antibody [NBP1-76816] - Immunofluorescence of KIF5 in K562 cells with KIF5 antibody at 20 ug/mL.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ELISA, ICC/IF

     1 Review

NBP1-76990
Western Blot: SPG11 Antibody [NBP1-76990] - Mouse heart tissue lysate with SPG11 antibody at (A) 0.5 and (B) 1 ug/mL.Immunohistochemistry-Paraffin: SPG11 Antibody [NBP1-76990] - Mouse brain tissue with SPG11 antibody at 2.5 ug/mL.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ELISA, IHC

NBP1-77397
Immunocytochemistry/Immunofluorescence: HSP60 Antibody [NBP1-77397] - HeLa cells were fixed in 4% paraformaldehyde for 10 minutes and permeabilized in 0.05% Triton X-100 in PBS for 5 minutes. The cells were incubated with HSP60 Antibody (NBP1-77397) at 1 ug/ml overnight at 4C and detected with an anti-rabbit Dylight 488 (Green) at a 1:1000 dilution for 60 minutes. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 100X objective and digitally deconvolved.Western Blot: HSP60 Antibody [NBP1-77397] - Analysis of extracts from HeLa and COS cells using NBP1-77397 Hsp60 antibody at 1:1000

Rabbit Polyclonal
Species Human, Mouse
Applications WB, Simple Western, Flow

     4 Reviews

3 Publications
NBP1-89273
Western Blot: SPG21 Antibody [NBP1-89273] - Analysis in control (vector only transfected HEK293T lysate) and SPG21 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).Immunohistochemistry-Paraffin: SPG21 Antibody [NBP1-89273] - Staining of human gallbladder shows cytoplasmic positivity in glandular cells.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

NBP2-01860
Western Blot: SPG7 Antibody (OTI1C1) [NBP2-01860] - Analysis of extracts (35 ug) from 9 different cell lines by using anti-SPG7 monoclonal antibody.Immunocytochemistry/Immunofluorescence: SPG7 Antibody (OTI1C1) [NBP2-01860] - Staining of COS7 cells transiently transfected by pCMV6-ENTRY SPG7.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, Flow, ICC/IF

     1 Review

3 Publications
NBP2-13075
Immunohistochemistry: beta Amyloid Antibody (MOAB-2) [NBP2-13075] - IHC analysis of beta Amyloid on normal mouse brain (left) and 5xFAD mouse brain (right) using DAB with hematoxylin counterstain.  The MOAB-2 antibody was used at 1:20 on normal mouse brain and at 1:400 on 5xFAD mouse brain.Western Blot: beta Amyloid Antibody (MOAB-2) [NBP2-13075] - Analysis of beta Amyloid (MOAB-2) antibody in (1) 100 pmole beta Amyloid 42, (2) 5xFAD mouse brain homogenate Repetition 1 and (3) 5xFAD mouse brain homogenate Repetition 2.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, DB, ELISA

     2 Reviews

37 Publications
NBP2-24915
Western Blot: SOD1/Cu-Zn SOD Antibody [NBP2-24915] - Bovine ocular fluid. Antibody at 1:1000. Western blot image submitted by a verified customer review.Immunohistochemistry-Paraffin: SOD1/Cu-Zn SOD Antibody [NBP2-24915] - Analysis of Superoxide Dismutase 1 in FFPE human liver tissue using an isotype control (top) and NBP2-24915 (bottom) at 5 ug/ml.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC, IHC-P

     3 Reviews

9 Publications
AF7385
Western blot shows lysates of IMR‑32 human neuroblastoma cell line and HEK293 human embryonic kidney cell line. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human Seipin/BSCL2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7385) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # <a class=Seipin/BSCL2 was detected in immersion fixed human mesenchymal stem cells differentiated into adipocytes using Sheep Anti-Human Seipin/BSCL2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7385) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Sheep IgG Secondary Antibody (red; Catalog # <A class=NoLineLink href=

Sheep Polyclonal
Species Human
Applications WB, ICC

NB100-885
Immunohistochemistry: Als2 Antibody [NB100-885] - IHC staining of Als2 in paraffin embedded Human Cortex using NB100-885 at 3.8ug/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Goat Polyclonal
Species Human, Mouse
Applications IHC, IHC-P, PEP-ELISA

2 Publications
NBP2-59312
Western Blot: REEP1 Antibody (S345-51) [NBP2-59312] - Analysis of Rat Brain showing detection of ~22 kDa REEP1 protein using Mouse Anti-REEP1 Monoclonal Antibody, Clone S345-51.  Lane 1: MW Ladder. Lane 2: Rat Brain. Load: 20 ug . Block: 2% GE Healthcare Blocker for 1 hour at RT. Primary Antibody: Mouse Anti-REEP1 Monoclonal Antibody at 1:1000 for 16 hours at 4 degrees C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:200 for 1 hour at RT. Color Development: ECL solution for 6 min at RT. Predicted/Observed Size: ~22 kDa.Immunocytochemistry/Immunofluorescence: REEP1 Antibody (S345-51) [NBP2-59312] - Tissue: Neuroblastoma cell line SK-N-BE. Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-REEP1 Monoclonal Antibody at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000; 1:5000 for 60 min RT, 5 min RT. Localization: Cytoplasm, Nucleus. Magnification: 60X.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

H00051062-M03
Western Blot: SPG3A Antibody (1B9) [H00051062-M03] - Analysis of SPG3A expression in PC-12 (Cat # L012V1).Western Blot: SPG3A Antibody (1B9) [H00051062-M03] - Analysis of SPG3A expression in IMR-32 (Cat # L008V1).

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, IHC

1 Publication
H00006683-M02
Western Blot: Spastin Antibody (2F5) [H00006683-M02] - SPAST monoclonal antibody (M02), clone 2F5. Analysis of SPAST expression in Jurkat.Immunocytochemistry/Immunofluorescence: Spastin Antibody (2F5) [H00006683-M02] - Analysis of monoclonal antibody to SPAST on HeLa cell . Antibody concentration 10 ug/ml.

Mouse Monoclonal
Species Human
Applications WB, ELISA, ICC/IF

NBP2-83269
Western Blot: NIPA1 Antibody [NBP2-83269] - WB Suggested Anti-NIPA1 Antibody. Titration: 1.0 ug/ml. Positive Control: 721_B Whole Cell

Rabbit Polyclonal
Species Human
Applications WB

H00008086-M02
Western Blot: AAAS Antibody (5A1) [H00008086-M02] - AAAS monoclonal antibody (M02), clone 5A1. Analysis of AAAS expression in NIH/3T3.Immunohistochemistry-Paraffin: AAAS Antibody (5A1) [H00008086-M02] - Analysis of monoclonal antibody to AAAS on formalin-fixed paraffin-embedded human prostate. Antibody concentration 3 ug/ml.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, IHC


Related Genes

Spastic Paraplegia, Hereditary has been researched against:

Related PTMs

Spastic Paraplegia, Hereditary has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Spastic Paraplegia, Hereditary is also known as Cmt With Pyramidal Features, Hereditary Motor And Sensory Neuropathy Type V, Hereditary Motor And Sensory Neuropathy V, Hereditary Spastic Paraplegia, Hereditary Spastic Paraplegias.