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Spastic Paraplegia: Disease Bioinformatics

Research of Spastic Paraplegia has been linked to Paraplegia, Spastic Paraplegia, Hereditary, Muscle Spasticity, Neurodegenerative Disorders, Atrophy. The study of Spastic Paraplegia has been mentioned in research publications which can be found using our bioinformatics tool below. Researched pathways related to Spastic Paraplegia include Pathogenesis, Transport, Cell Adhesion, Localization, Translation. These pathways complement our catalog of research reagents for the study of Spastic Paraplegia including antibodies and ELISA kits against SPAST, ATL1, PLP1, L1CAM, SPG7.

Spastic Paraplegia Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Spastic Paraplegia below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 1477 products for the study of Spastic Paraplegia that can be applied to Chromatin Immunoprecipitation, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

NB100-2682
Western Blot: L1CAM Antibody (UJ127.11) [NB100-2682] - SUM159 cells were exposed to 20% or 1% O2 for 48 hours, whole cell lysates were loaded with 50 ug/lane. 10% SDS-PAGE. L1CAM Antibody (NB100-2682) primary antibody: 1:1000, 4C, overnight. Western blot image submitted by a verified customer review.Immunocytochemistry/Immunofluorescence: L1CAM Antibody (UJ127.11) [NB100-2682] - The left panel (A) shows untreated Neuro2a cells and the right panel (B) shows Neuro2a cells that were serum starved then treated with 1mM cAMP overnight to induce axon growth. Cells were fixed in 4% paraformaldehyde for 10 minutes and then permeabilized for 5 minutes using 1X PBS + 0.05% Triton-X100. The cells were incubated with anti- NB100-2682 at 5 ug/ml overnight at 4C and detected with an anti-mouse Dylight 488 (Green) at a 1:1000 dilution for 60 minutes. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 100X objective and digitally deconvolved.

Mouse Monoclonal
Species Human, Mouse
Applications WB, ELISA, Flow

     2 Reviews

2 Publications
NBP1-47203
Western Blot: SPG20 Antibody [NBP1-47203] - (2ug/ml) staining of HeLa lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunocytochemistry/Immunofluorescence: SPG20 Antibody [NBP1-47203] - (2ug/ml) staining of methanol-fixed HeLa before (left) and after (right) introduction of siRNA.

Goat Polyclonal
Species Human
Applications WB, ICC/IF, PEP-ELISA

1 Publication
NBP1-76816
Western Blot: Kinesin 5A Antibody [NBP1-76816] - K562 cell lysate with Kinesin 5A antibody at (A) 0.5 and (B) 1 ug/ml.Immunocytochemistry/Immunofluorescence: Kinesin 5A Antibody [NBP1-76816] - Immunofluorescence of KIF5 in K562 cells with KIF5 antibody at 20 ug/mL.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ELISA, ICC/IF

     1 Review

NBP1-76990
Western Blot: SPG11 Antibody [NBP1-76990] - Mouse heart tissue lysate with SPG11 antibody at (A) 0.5 and (B) 1 ug/mL.Immunohistochemistry-Paraffin: SPG11 Antibody [NBP1-76990] - Mouse brain tissue with SPG11 antibody at 2.5 ug/mL.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ELISA, IHC

NBP1-77397
Immunocytochemistry/Immunofluorescence: HSP60 Antibody [NBP1-77397] - HeLa cells were fixed in 4% paraformaldehyde for 10 minutes and permeabilized in 0.05% Triton X-100 in PBS for 5 minutes. The cells were incubated with HSP60 Antibody (NBP1-77397) at 1 ug/ml overnight at 4C and detected with an anti-rabbit Dylight 488 (Green) at a 1:1000 dilution for 60 minutes. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 100X objective and digitally deconvolved.Western Blot: HSP60 Antibody [NBP1-77397] - Analysis of extracts from HeLa and COS cells using NBP1-77397 Hsp60 antibody at 1:1000

Rabbit Polyclonal
Species Human, Mouse
Applications WB, Simple Western, Flow

     4 Reviews

3 Publications
NBP1-87781
Immunohistochemistry-Paraffin: Myelin PLP Antibody [NBP1-87781] - Staining in human cerebral cortex and pancreas tissues using anti-PLP1 antibody. Corresponding PLP1 RNA-seq data are presented for the same tissues.Immunohistochemistry-Paraffin: Myelin PLP Antibody [NBP1-87781] - Border of a demyelinated lesion. Image submitted by a verified customer review.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, IHC, IHC-P

     1 Review

2 Publications
NBP1-90230
Western Blot: Spastin Antibody [NBP1-90230] - Lane 1: Marker  [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.  Lane 2: Human cell line RT-550Immunocytochemistry/Immunofluorescence: Spastin Antibody [NBP1-90230] - Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & cytosol. Antibody staining is shown in green.

Rabbit Polyclonal
Species Human, Rat
Applications WB, ICC/IF, IHC

NBP2-01860
Western Blot: SPG7 Antibody (OTI1C1) [NBP2-01860] - Analysis of extracts (35 ug) from 9 different cell lines by using anti-SPG7 monoclonal antibody.Immunocytochemistry/Immunofluorescence: SPG7 Antibody (OTI1C1) [NBP2-01860] - Staining of COS7 cells transiently transfected by pCMV6-ENTRY SPG7.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, Flow, ICC/IF

     1 Review

3 Publications
NBP2-13075
Immunohistochemistry: beta Amyloid Antibody (MOAB-2) [NBP2-13075] - IHC analysis of beta Amyloid on normal mouse brain (left) and 5xFAD mouse brain (right) using DAB with hematoxylin counterstain.  The MOAB-2 antibody was used at 1:20 on normal mouse brain and at 1:400 on 5xFAD mouse brain.Western Blot: beta Amyloid Antibody (MOAB-2) [NBP2-13075] - Analysis of beta Amyloid (MOAB-2) antibody in (1) 100 pmole beta Amyloid 42, (2) 5xFAD mouse brain homogenate Repetition 1 and (3) 5xFAD mouse brain homogenate Repetition 2.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, DB, ELISA

     2 Reviews

40 Publications
NBP2-14284
Immunocytochemistry/Immunofluorescence: Als2 Antibody [NBP2-14284] - Over-expression of Alsin or Rab5 blocks caspase-3/7 activation.(A) HeLa cells transiently expressing empty vector, Alsin, or Rab5 were incubated in the presence of 500 uM H2O2 and 5 uM CellEvent caspase-3/7 green detection reagent at 37 degrees C for 2 hr. Nucleus was stained with DAPI (blue). Images were acquired by confocal microscopy. Caspase-activated cells displayed green signals, while non-activated cells (PBS control) showed no signal. Percent of cells with positive signals were quantified in (B), n = 50. Image collected and cropped by CiteAb from the following publication (elifesciences.org/articles/32282), licensed under a CC-BY licence.Immunohistochemistry-Paraffin: Als2 Antibody [NBP2-14284] - Staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.

Rabbit Polyclonal
Species Human
Applications ICC/IF, IHC, IHC-P

1 Publication
NBP2-27461
Western Blot: PDXP Antibody [NBP2-27461] - 0.1 ug/ml staining of Mouse (A) and Rat (B) Brain lysates (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry-Paraffin: PDXP Antibody [NBP2-27461] - 5ug/ml staining of paraffin embedded Human Tonsil. Steamed antigen retrieval with citrate buffer Ph 6, AP-staining.

Goat Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC, IHC-P

1 Publication
NBP2-35224
SDS-Page: Human PTHLH/PTHrP Protein [NBP2-35224]


Species Human
Applications Func, PAGE

AF5724
Western blot shows lysates of human, mouse, and rat brain tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse/Rat Peroxiredoxin 5 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5724) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class=    Peroxiredoxin 5  was detected in immersion fixed A549 human lung carcinoma cell line using  Goat Anti-Human/Mouse/Rat Peroxiredoxin 5 Antigen Affinity-purified  Polyclonal Antibody (Catalog # AF5724) at 10 µg/mL for 3  hours at room temperature. Cells were stained using the  NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody  (red; Catalog # <a class=

Goat Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC

NBP2-38445
Western Blot: RNF6 Antibody [NBP2-38445] - Analysis in control (vector only transfected HEK293T lysate) and RNF6 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).Immunocytochemistry/Immunofluorescence: RNF6 Antibody [NBP2-38445] - Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear membrane.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

DVC00
 VCAM-1/CD106 [HRP] VCAM-1/CD106 [HRP]


Species Human
Applications ELISA

     3 Reviews

92 Publications
NBP2-56164
Western Blot: SPG21 Antibody [NBP2-56164] - Western blot analysis in human cell line RT-4, human cell line U-251 MG, human plasma, human liver tissue and human tonsil tissue.Immunocytochemistry/Immunofluorescence: SPG21 Antibody [NBP2-56164] - Staining of human cell line A549 shows localization to cytosol & vesicles.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF

NBP2-59312
Western Blot: REEP1 Antibody (S345-51) [NBP2-59312] - Analysis of Rat Brain showing detection of ~22 kDa REEP1 protein using Mouse Anti-REEP1 Monoclonal Antibody, Clone S345-51.  Lane 1: MW Ladder. Lane 2: Rat Brain. Load: 20 ug . Block: 2% GE Healthcare Blocker for 1 hour at RT. Primary Antibody: Mouse Anti-REEP1 Monoclonal Antibody at 1:1000 for 16 hours at 4 degrees C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:200 for 1 hour at RT. Color Development: ECL solution for 6 min at RT. Predicted/Observed Size: ~22 kDa.Immunocytochemistry/Immunofluorescence: REEP1 Antibody (S345-51) [NBP2-59312] - Tissue: Neuroblastoma cell line SK-N-BE. Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-REEP1 Monoclonal Antibody at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000; 1:5000 for 60 min RT, 5 min RT. Localization: Cytoplasm, Nucleus. Magnification: 60X.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

H00051062-M03
Western Blot: SPG3A Antibody (1B9) [H00051062-M03] - Analysis of SPG3A expression in PC-12 (Cat # L012V1).Western Blot: SPG3A Antibody (1B9) [H00051062-M03] - Analysis of SPG3A expression in IMR-32 (Cat # L008V1).

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, IHC

1 Publication
H00008086-M02
Western Blot: AAAS Antibody (5A1) [H00008086-M02] - AAAS monoclonal antibody (M02), clone 5A1. Analysis of AAAS expression in NIH/3T3.Immunohistochemistry-Paraffin: AAAS Antibody (5A1) [H00008086-M02] - Analysis of monoclonal antibody to AAAS on formalin-fixed paraffin-embedded human prostate. Antibody concentration 3 ug/ml.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, IHC