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Sotos' Syndrome: Disease Bioinformatics

Research of Sotos' Syndrome has been linked to Gigantism, Growth Disorders, Brain Diseases, Macrocephaly, Craniofacial Abnormalities. The study of Sotos' Syndrome has been mentioned in research publications which can be found using our bioinformatics tool below. Researched pathways related to Sotos' Syndrome include Feeding Behavior, Pathogenesis, Secretion, Long-term Memory, Methylation. These pathways complement our catalog of research reagents for the study of Sotos' Syndrome including antibodies and ELISA kits against NSD1, GROWTH HORMONE, BBS9, SPANXB1, MS4A1.

Sotos' Syndrome Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Sotos' Syndrome below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 1957 products for the study of Sotos' Syndrome that can be applied to Chromatin Immunoprecipitation, Western Blot, Flow Cytometry, Immunohistochemistry, Chromatin Immunoprecipitation (ChIP), Immunocytochemistry/Immunofluorescence from our catalog of antibodies and ELISA kits.

NB100-1744
Immunohistochemistry-Paraffin: KMT3B/NSD1 Antibody [NB100-1744] - Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-NSD1 used at a dilution of 1:250. Detection: DAB staining using Immunohistochemistry Accessory Kit.Immunohistochemistry-Paraffin: KMT3B/NSD1 Antibody [NB100-1744] - Sample : FFPE section of human prostate adenocarcinoma. Antibody: Affinity purified rabbit anti-NSD1 used at a dilution of 1:250. Detection: DAB

Rabbit Polyclonal
Species Human
Applications IHC, IHC-P

1 Publication
NBP1-88927
Immunohistochemistry-Paraffin: BBS9 Antibody [NBP1-88927] - Staining of human cerebellum shows strong cytoplasmic positivity in purkinje cells.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ICC/IF, IHC

3 Publications
H00728695-B01P
Western Blot: SPANXB1 Antibody [H00728695-B01P] - Analysis of SPANXB1 expression in transfected 293T cell line by SPANXB1 polyclonal antibody.  Lane 1: SPANXB1 transfected lysate(11.33 KDa). Lane 2: Non-transfected lysate.Immunocytochemistry/Immunofluorescence: SPANXB1 Antibody [H00728695-B01P] - Analysis of purified antibody to SPANXB1 on Hs 181.Tes cell. (antibody concentration 10 ug/ml)

Mouse Polyclonal
Species Human
Applications WB, ICC/IF, IP

NBP2-44743
Western Blot: CD20 Antibody (L26) [NBP2-44743] - Western Blot Analysis of Raji cell lysate using CD20 Mouse Monoclonal Antibody (L26).Immunocytochemistry/Immunofluorescence: CD20 Antibody (L26) [NBP2-44743] - Immunofluorescence staining of Raji cells using CD20 Mouse Monoclonal Antibody (L26) followed by goat anti-Mouse IgG conjugated to CF488 (green). Nuclei are stained with Reddot.

Mouse Monoclonal
Species Human, Baboon, Monkey
Applications WB, Flow, ICC/IF

2 Publications
NB100-858
Immunocytochemistry/Immunofluorescence: nNOS Antibody [NB100-858] - Electrophysiological properties of colonic myenteric neurons from non-treated & chemotherapy-treated patients. Action potentials were evoked with depolarizing current pulses. (A) Neuron from colonic specimen of non-treated patient fired a single action potential in response to a depolarizing current. (A') Intracellular injection of carboxyfluorescein during recording confirmed Dogiel type I, uniaxonal morphology. (AImmunohistochemistry-Paraffin: nNOS Antibody [NB100-858] - Staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Antibody at 2.5 ug/mL.

Goat Polyclonal
Species Human, Mouse, Rat
Applications WB, Flow, ICC/IF

     1 Review

13 Publications
NBP1-90364
Western Blot: CREB Antibody [NBP1-90364] - Lane 1: Marker  [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.  Lane 2: Human cell line RT-4.  Lane 3: Human cell line U-251MG spImmunocytochemistry/Immunofluorescence: CREB Antibody [NBP1-90364] - Staining of human cell line U-2 OS shows localization to nucleoplasm. Antibody staining is shown in green.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, ICC/IF

     3 Reviews

2 Publications
NBP2-25196
Immunocytochemistry/Immunofluorescence: CD19 Antibody (CB19) [NBP2-25196] - The CD19 (CB19) antibody was tested in Daudi cells at a 1:40 dilution against Dylight 488 (Green). Actin and nuclei were counterstained against Phalloidin 568 (Red) and DAPI (Blue), respectively.Flow Cytometry: CD19 Antibody (CB19) [NBP2-25196] - A surface stain was performed on Ramos cells with CD19 Antibody (CB19) NBP2-26646 (blue) and a matched isotype control (orange). Cells were incubated in an antibody dilution of 2.5 ug/mL for 20 minutes at room temperature. Both antibodies were conjugated to phycoerythrin.

Mouse Monoclonal
Species Human, Mouse
Applications WB, Flow, ICC/IF

11 Publications
NBP2-37483
Western Blot: Glypican 3 Antibody (9C2) [NBP2-37483] - Analysis using GPC3 mouse mAb against HepG2 (1), HEK293 (2), Jurkat (3), SK-N-SH (4), PC-12 (5), F9 (6)and Mouse liver (7) cell lysate.Immunocytochemistry/Immunofluorescence: Glypican 3 Antibody (9C2) [NBP2-37483] - Analysis of HeLa cells using GPC3 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.

Mouse Monoclonal
Species Human, Mouse
Applications WB, ELISA, Flow

NBP1-82633
Immunohistochemistry-Paraffin: WHSC1 Antibody [NBP1-82633] - Staining in human testis and liver tissues using anti-NSD2 antibody. Corresponding NSD2 RNA-seq data are presented for the same tissues.Immunocytochemistry/Immunofluorescence: WHSC1 Antibody [NBP1-82633] - Staining of human cell line A-431 shows positivity in nucleus but not nucleoli. Antibody staining is shown in green.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

3 Publications
NBP2-34260
Western Blot: Insulin Antibody (E2-E3 (same as INS04)) [NBP2-34260] - Probing of Western blots of pancreatic lysates from control and iron overloaded Tg40 PrP and PrP-/- mice with antibodies specific for insulin dimer and pentamer (upper and lower panels) shows decreased expression in Tg40 PrP relative to PrP-/- samples (lanes 1 & 5 vs. 3 & 7). Image collected and cropped by CiteAb from the following publication (nature.com/articles/s41598-018-24786-1), licensed under a CC-BY licence.Immunohistochemistry: Insulin Antibody (E2-E3 (same as INS04)) [NBP2-34260] - Immunohistochemistry of pancreas shows relatively higher reactivity for insulin in PrP-/- relative to Tg40 PrP sections (panels 1 & 3). Iron overloading decreases insulin reactivity in Tg40 PrP but not in PrP-/- samples (panels 1 vs. 2 & 3 vs. 4). Reaction for glucagon is higher in iron overloaded Tg40 PrP relative to control samples (panels 5 & 6). The difference is minimal in PrP-/- samples (panels 7 & 8). Image collected and cropped by CiteAb from the following publication (http://www.nature.com/articles/s41598-018-24786-1), licensed under a CC-BY licence.

Mouse Monoclonal
Species Human, Mouse, Porcine
Applications WB, ICC/IF, IHC

     5 Reviews

2 Publications
NBP2-20383
Western Blot: SLC17A5 Antibody [NBP2-20383] - Sample (30 ug of whole cell lysate) A: Jurkat 10% SDS PAGE gel, diluted at 1:1000.Immunocytochemistry/Immunofluorescence: SLC17A5 Antibody [NBP2-20383] - Sample: HepG2 cells were fixed in -20C 100% MeOH for 5 min. Green: SLC17A5 protein stained by SLC17A5 antibody diluted at 1:500. Blue: Hoechst 33343 staining.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ICC/IF, IHC

NBP2-67674
Western Blot: NSD3 Antibody (SN07-11) [NBP2-67674] - Analysis of NSD3 on different lysates using anti-NSD3 antibody at 1/1,000 dilution. Positive control: Lane 1: MCF-7 Lane 2: 293TFlow Cytometry: NSD3 Antibody (SN07-11) [NBP2-67674] - Flow cytometric analysis of Hela cells with NSD3 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody

Rabbit Monoclonal
Species Human, Mouse, Rat
Applications WB, Flow, IHC

NBP2-59320
Western Blot: SUR1 Antibody (S289-16) [NBP2-59320] - Analysis of mouse pancreatic islets. Lane 1: Molecular Weight Ladder. Lanes 2-5: Samples from pooled pancreatic islets. Load: ~10ug. Primary Antibody: Anti-SUR1 Monoclonal Antibody at 1:200 for ~16hrs at 4C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:1000 for 1hr RT. Image from verified customer review.Immunocytochemistry/Immunofluorescence: SUR1 Antibody (S289-16) [NBP2-59320] - Glial fibrillary acidic protein (GFAP)-positive specimens from human contusion- traumatic brain injury (TBI) exhibit sulfonylurea receptor 1 (SUR1) expression in astrocytes.Double immunolabeling for SUR1 (red) and GFAP (green) showed astrocyte expression of SUR1; merged images confirm co-localization (yellow); in situ hybridization of the same tissue section for Abcc8 messenger RNA showed positive signal co-localized with GFAP-positive, SUR1-expressing astrocytes; arrowheads point to cells with all three signals. Image collected and cropped by CiteAb from the following publication (//www.liebertpub.com/doi/10.1089/neu.2018.5986) licensed under a CC-BY licence.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

     2 Reviews

2 Publications
291-G1
1 μg/lane of Recombinant Human IGF-I/IGF-1 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 7 kDa.Recombinant Human IGF-I/IGF-1 (Catalog # 291-G1) stimulates proliferation in the MCF-7 human breast cancer cell line. The ED<sub>50</sub> for this effect is 0.3‑1.5 ng/mL.


Species Human

     8 Reviews

153 Publications
DGB300
 IGFBP-3 [HRP] IGFBP-3 [HRP]


Species Human

     3 Reviews

37 Publications

Related Genes

Sotos' Syndrome has been researched against:

Related PTMs

Sotos' Syndrome has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Sotos' Syndrome is also known as Cerebral Giant, Cerebral Gigantism, Cerebral Gigantism Syndrome, Gigantism, Cerebral, Soto Syndrome.