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Severe Mental Retardation: Disease Bioinformatics

Research of Severe Mental Retardation has been linked to Epilepsy, Microcephaly, Congenital Abnormality, Cytogenetic Abnormality, Muscle Hypotonia. The study of Severe Mental Retardation has been mentioned in research publications which can be found using our bioinformatics tool below. Researched pathways related to Severe Mental Retardation include Pathogenesis, Methylation, Myelination, Excretion, Transport. These pathways complement our catalog of research reagents for the study of Severe Mental Retardation including antibodies and ELISA kits against STRABISMUS, SLC25A5, ATRX, DCX, DMD.

Severe Mental Retardation Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Severe Mental Retardation below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 874 products for the study of Severe Mental Retardation that can be applied to Chromatin Immunoprecipitation, Flow Cytometry, Western Blot, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.

NB100-56326
Western Blot: MeCP2 Antibody [NB100-56326] - analysis of MeCP2 in HeLa cell lysate using this antibody.Immunocytochemistry/Immunofluorescence: MeCP2 Antibody [NB100-56326] - MeCP2 antibody was tested in A431 cells at a 1:200 dilution against Dylight 488 (Green). Alpha tubulin and nuclei were counterstained against Dylight 568 (Red) and DAPI (Blue), respectively.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ICC/IF, IHC

1 Publication
NBP1-52084
Western Blot: Phenylalanine Hydroxylase Antibody [NBP1-52084] - (0.1ug/ml) staining of Mouse (A) and Rat (B) Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry-Paraffin: Phenylalanine Hydroxylase Antibody [NBP1-52084] - Staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Goat Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC-P, PEP-ELISA

1 Publication
NBP1-83077
Western Blot: ATRX Antibody [NBP1-83077] - Analysis in human cell line A-549.Immunohistochemistry-Paraffin: ATRX Antibody [NBP1-83077] - Immunohistochemical staining of human fallopian tube shows moderate to strong nuclear positivity in glandular cells.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

16 Publications
NB500-240
Western Blot: E6AP/UBE3A Antibody [NB500-240] - UBE3A Antibody [NB500-240] -  Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded), 293T (T; 50 mcg), and mouse NIH3T3 (M; 50 mcg) cells.   Antibodies: Affinity purified rabbit anti-E6AP antibody used for WB at 0.4 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate.  E6AP was also immunoprecipitated by rabbit anti-E6AP antibody, which recognizes an upstream epitope.    Detection: Chemiluminescence with exposure times of 3 minutes (A and B).

Rabbit Polyclonal
Species Human, Mouse
Applications WB, IP

8 Publications
NBP2-57308
Immunocytochemistry/Immunofluorescence: MCT8/SLC16A2 Antibody [NBP2-57308] - Staining of human cell line U-251 MG shows localization to plasma membrane.Immunohistochemistry-Paraffin: MCT8/SLC16A2 Antibody [NBP2-57308] - Staining of human kidney shows moderate membranous positivity in cells in tubules.

Rabbit Polyclonal
Species Human, Mouse
Applications ICC/IF, IHC, IHC-P

NB120-7164
Immunohistochemistry-Frozen: Dystrophin Antibody (MANDRA1) [NB120-7164] - Staining of frozen human tongue sections with 1:100 Monoclonal Anti-Dystrophin, Clone: MANDRA1 using Goat Anti-Mouse IgG, FITC-conjugate.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications ELISA, ICC/IF, IHC-Fr

3 Publications
NBP2-32157
Western Blot: CDKL5 Antibody [NBP2-32157] - Samples:  Whole cell lysate (50 ug) from HeLa cells.  Antibodies:  Affinity purified rabbit anti-CDKL5 antibody NBP2-32157 used for WB at 0.4 ug/ml.  Detection: Chemiluminescence with an exposure time of 3 minutes.Immunohistochemistry-Paraffin: CDKL5 Antibody [NBP2-32157] - Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti- CDKL5 used at a dilution of 1:5,000 (0.2ug/ml). Detection: DAB. Counterstain: IHC Hematoxylin (blue).

Rabbit Polyclonal
Species Human
Applications WB, IHC-P, IP

NBP1-92025
Western Blot: Invadolysin Antibody [NBP1-92025] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells). Lane 2: NBT-II cell lysate (Rat Wistar bladder tumor cells).Immunocytochemistry/Immunofluorescence: Invadolysin Antibody [NBP1-92025] - Immunofluorescent staining of human cell line A-431 shows localization to cytosol & focal adhesion sites.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

H00027130-P02
12.5% SDS-PAGE Stained with Coomassie Blue.


Species Human

NB110-89456
Western Blot: Myoglobin Antibody (5A2G8) [NB110-89456] - Analysis using Myoglobin mouse mAb against truncated Myoglobin recombinant protein(AA: 2-154).Immunohistochemistry-Paraffin: Myoglobin Antibody (5A2G8) [NB110-89456] - Analysis of paraffin-embedded human skeletal muscle tissue showing cytoplasmic localization using anti-Myoglobin antibody with DAB staining.

Mouse Monoclonal
Species Human
Applications WB, ELISA, IHC

NBP2-01770
Western Blot: FMRP Antibody (1C6) [NBP2-01770] Analysis of extracts (35ug) from 9 different cell lines by using anti-FMRP monoclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).Immunocytochemistry/Immunofluorescence: FMRP Antibody (1C6) [NBP2-01770] - Staining of COS7 cells transiently transfected by pCMV6-ENTRY FMRP.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, Flow, ICC/IF

NBP1-82991
Western Blot: ZEB2 Antibody [NBP1-82991] - Analysis in human cell line HELA.Immunohistochemistry-Paraffin: ZEB2 Antibody [NBP1-82991] - Analysis in human cerebral cortex and pancreas tissues using HPA003456 antibody. Corresponding ZEB2 RNA-seq data are presented for the same tissues.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, IHC, IHC-P

     1 Review

8 Publications
NBP2-34260
Immunohistochemistry-Paraffin: Insulin Antibody (E2-E3 (same as INS04)) [NBP2-34260] - Formalin-fixed, paraffin-embedded human pancreas stained with insulin Monoclonal Antibody (E2-E3)SDS-Page: Insulin Antibody (E2-E3 (same as INS04)) [NBP2-34260]

Mouse Monoclonal
Species Human, Mouse, Porcine
Applications WB, Flow, ICC/IF

     4 Reviews

H00006934-M06
Western Blot: TCF7L2 Antibody (3A4) [H00006934-M06] - Analysis of TCF7L2 expression in K-562 (Cat # L009V1).Immunocytochemistry/Immunofluorescence: TCF7L2 Antibody (3A4) [H00006934-M06] - Analysis of monoclonal antibody to TCF7L2 on HeLa cell. Antibody concentration 10 ug/ml

Mouse Monoclonal
Species Human
Applications WB, ELISA, ICC/IF

     1 Review

1 Publication
NBP1-87769
Western Blot: LIS1 Antibody [NBP1-87769] - Lane 1: Marker  [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.  Lane 2: Human cell line RT-4.  Lane 3: Human cell line U-251MG spImmunocytochemistry/Immunofluorescence: LIS1 Antibody [NBP1-87769] - Immunofluorescent staining of human cell line U-251 MG shows localization to centrosome.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

     2 Reviews

NBP1-92684
Western Blot: Doublecortin Antibody (3E1) [NBP1-92684] - Western blot of crude rat brain extract from a postnatal 3 day animal stained with NBP1-92684. Two bands at ~45kDa and ~35kDa show that NBP1-92684 binds to an epitope in the region of Doublecortin shared by Lis-A, and Lis-B, Lis-C and Lis-D, the C terminal 360 amino acids of Lis-A.Immunocytochemistry/Immunofluorescence: Doublecortin Antibody (3E1) [NBP1-92684] - Rat brain neural cultures stained with NBP1-92684 (green), a chicken polyclonal antibody to GFAP (NB300-213, red) and DNA (blue). The NBP1-92684 antibody reveals strong cytoplasmic staining in a population of small developing neurons. These cells are often found in small clumps as in these cultures, as in this example. Note that they are not positive for MAP2, which is characteristic of more mature neurons, and that the mature neuron shown is negative for NBP1-92684. This Doublecortin antibody is therefore an excellent marker of developing neuronal cells.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF

NBP1-56594
Western Blot: FOXG1A/FOXG1B Antibody [NBP1-56594] - Jurkat cell lysate, Antibody Titration: 5.0-8.0ug/mlImmunohistochemistry-Paraffin: FOXG1A/FOXG1B Antibody [NBP1-56594] - Human Liver Tissue, antibody concentration 4-8ug/ml. Cells with positive label: Hepatocytes (indicated with arrows) 400X magnification.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

NBP2-56762
Western Blot: Adenine Nucleotide Translocator 2 Antibody [NBP2-56762] - Western blot analysis in human cell line RT-4 and human cell line U-251 MG.Immunocytochemistry/Immunofluorescence: Adenine Nucleotide Translocator 2 Antibody [NBP2-56762] - Staining of human cell line PC-3 shows localization to mitochondria.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF

AF1518
Western blot shows lysates of HEK293 human embryonic kidney cell line, PC‑12 rat adrenal pheochromocytoma cell line, and NIH‑3T3 mouse embryonic fibroblast cell line. PVDF membrane was probed with 0.1 µg/mL of Rabbit Anti-Human/Mouse/Rat RSK2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1518) followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # <A class=NoLineLink href=RSK2 was detected in immersion fixed frozen sections of mouse embryo using Rabbit Anti-Human/Mouse/Rat RSK2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1518) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Rabbit HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # <A class=NoLineLink href=

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC


Related Genes

Severe Mental Retardation has been researched against:

Related PTMs

Severe Mental Retardation has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Severe Mental Retardation is also known as Severe Intellectual Disabilities, Severe Mental Handicap, Severe Mental Subnormality.