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Severe Congenital Neutropenia: Disease Bioinformatics

Research of Severe Congenital Neutropenia has been linked to Leukemia, Infective Disorder, Agranulocytosis, Leukemia, Myelocytic, Acute, Myeloid Leukemia. The study of Severe Congenital Neutropenia has been mentioned in research publications which can be found using our bioinformatics tool below. Researched pathways related to Severe Congenital Neutropenia include Pathogenesis, Chemotaxis, Transport, Localization, Cell Death. These pathways complement our catalog of research reagents for the study of Severe Congenital Neutropenia including antibodies and ELISA kits against ELANE, CSF3, CSF3R, G-CSF, HAX1.

Severe Congenital Neutropenia Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Severe Congenital Neutropenia below! For more information on how to use Laverne, please read the How to Guide.
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Top Research Reagents

We have 1841 products for the study of Severe Congenital Neutropenia that can be applied to Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

LEF1 Antibody (3H5)
H00051176-M01
Western Blot: LEF1 Antibody (3H5) [H00051176-M01] - LEF1 monoclonal antibody (M01), clone 3H5 Analysis of LEF1 expression in MES-SA/Dx5.Western Blot: LEF1 Antibody (3H5) [H00051176-M01] - Analysis of LEF1 over-expressed 293 cell line, cotransfected with LEF1 Validated Chimera RNAi ( Cat # H00051176-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with LEF1 monoclonal antibody (M01), clone 3H5 (Cat # H00051176-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.

Mouse Monoclonal
Species Human, Mouse
Applications WB, ELISA, ICC/IF

3 Publications
HAX-1 Antibody
NBP1-31647
Western Blot: HAX-1 Antibody [NBP1-31647] - Various whole cell extracts (30 ug) were separated by 12% SDS-PAGE, and the membrane was blotted with HAX1 antibody diluted by 1:1000. The HRP-conjugated anti-rabbit IgG antibody (NBP2-19301) was used to detect the primary antibody.Immunocytochemistry/Immunofluorescence: HAX-1 Antibody [NBP1-31647] - Analysis of methanol-fixed A431, using HAX1 antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with an alpha Tubulin antibody (Red) at 1:2000.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

CD34 Antibody (MEC 14.7)
NB600-1071
Immunocytochemistry/Immunofluorescence: CD34 Antibody (MEC 14.7) [NB600-1071] - CD34 antibody was tested in WEHI-3 cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and DyLight 550 (red).Immunohistochemistry-Paraffin: CD34 Antibody (MEC 14.7) [NB600-1071] - Analysis of a FFPE tissue section of mouse small intestine using rat anti-mouse CD34 (clone MEC 14.7) at 1:100 dilution. The signal was developed using HRP-conjugated anti-rat secondary with DAB reagent which followed counterstaining of nuclei using hematoxylin. This antibody specifically labelled the endothelial cells in blood vessels located primarily in the sub-mucosa, and of that of the mucosa muscularis and the mucosal lacteal.

Rat Monoclonal
Species Mouse, Human (Negative)
Applications WB, ELISA, Flow

24 Publications
ASXL1 Antibody (6E2)
H00171023-M05
Western Blot: ASXL1 Antibody (6E2) [H00171023-M05] - Functional effects of CRISPR/Cas9-mediated ASXL1 mutation correction. Evaluation of ASXL1 protein expression by Western blotting. Left-hand side: ASXL1 protein expression in the SET2 leukemia cell line (wild-type for ASXL1), uncorrected KBM5 cells, the K562 leukemia cell line (carrying the Y591X heterozygous ASXL1 mutation), and KBM5 clones (labeled 1-5) with heterozygous precise correction of the ASXL1 mutation. Right-hand side: ASXL1 protein expression in the SET2 leukemia cell line (wild-type for ASXL1), uncorrected KBM5 cells, and KBM5 clones (labeled 1-5) with homozygous precise correction of the ASXL1 mutation. Beta-actin was used as loading control. Image collected and cropped by CiteAb from the following publication (//www.oncotarget.com/fulltext/6392) licensed under a CC-BY license.Western Blot: ASXL1 Antibody (6E2) [H00171023-M05] - Analysis of ASXL1 expression in MCF-7 (Cat # L046V1).

Mouse Monoclonal
Species Human
Applications WB, ELISA, IP

3 Publications
G6PC Antibody
NBP1-80533
Western Blot: G6PC Antibody [NBP1-80533] - Host: Rabbit. Target Name: G6PC. Sample Tissue: Mouse Testis. Antibody Dilution: 1ug/mlWestern Blot: G6PC Antibody [NBP1-80533] - Mouse Intestine, concentration 1 ug/ml.

Rabbit Polyclonal
Species Human, Mouse
Applications WB

     1 Review

9 Publications
LIS1 Antibody
NBP1-87769
Immunohistochemistry-Paraffin: LIS1 Antibody [NBP1-87769] - Analysis in human testis and liver tissues using NBP1-87769 antibody. Corresponding PAFAH1B1 RNA-seq data are presented for the same tissues.Western Blot: LIS1 Antibody [NBP1-87769] - Analysis of LIS1 in caco-2 whole cell lysate using anti-LIS1 antibody. Image submitted by a verified customer review.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

     2 Reviews

14-3-3 epsilon Antibody
NBP1-89827
Western Blot: 14-3-3 epsilon Antibody [NBP1-89827] - Analysis in mouse cell line NIH-3T3 and rat cell line NBT-II.Immunocytochemistry/Immunofluorescence: 14-3-3 epsilon Antibody [NBP1-89827] - Staining 14-3-3 epsilon in methanol-fixed, rat primary motor neurons using anti-14-3-3 epsilon antibody (green). Nuclei were stained with DAPI (blue). Image from verified customer review.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

     1 Review

2 Publications
WASP Antibody
NB300-996
Immunocytochemistry/Immunofluorescence: WASP Antibody [NB300-996] - Immunofluorescence analysis of paraformaldehyde fixed U2OS cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (2 ug/mL), showing nuclear and cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (2 ug/mL).Immunohistochemistry-Paraffin: WASP Antibody [NB300-996] - Staining of paraffin embedded Human Spleen. Antibody at 5 ug/mL. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Goat Polyclonal
Species Human
Applications WB, Flow, ICC/IF

1 Publication
GFI-1 Antibody [Unconjugated]
AF3540
THP-1 monocytic leukemia cell line was stained with Goat Anti-Human GFI-1SOX2 Affinity Purified Polyclonal Antibody (Catalog # AF3540, filled histogram) or control antibody (Catalog # <a class=

Goat Polyclonal
Species Human
Applications WB, CyTOF-ready, ICFlow

4 Publications
G-CSFR/CD114 Antibody (38660) [Unconjugated]
MAB381
Western blot shows lysates of AML‑193 human acute monocytic leukemia cell line. PVDF membrane was probed with 1 µg/mL of Mouse Anti-Human G‑CSF R/CD114 Monoclonal Antibody (Catalog # MAB381) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # <A class=NoLineLink href=Human granulocytes were stained with Mouse Anti-Human G-CSF R/CD114 Monoclonal Antibody (Catalog # MAB381, filled histogram) or isotype control antibody (<a class=

Mouse Monoclonal
Species Human
Applications WB, Flow, CyTOF-ready

2 Publications
G-CSF [Unconjugated]
214-CS
Recombinant Human G-CSF (Catalog # 214-CS) stimulates cell proliferation of the NFS-60 mouse myelogenous leukemia lymphoblast cell line. The ED<SUB>50</SUB> for this effect is 10-60 pg/mL.1 μg/lane of Recombinant Human G-CSF was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 18.5 kDa.


Species Human
Applications BA

53 Publications
IL-3 [Unconjugated]
203-IL
<P align=left>Recombinant Human IL-3 (Catalog # 203-IL) stimulates cell proliferation of the TF-1 human erythroleukemic cell line. The ED<SUB>50</SUB> for this effect is 0.02-0.1 ng/mL.<P align=left>1 μg/lane of Recombinant Human IL-3 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 14 kDa.


Species Human
Applications BA

198 Publications
SCF/c-kit Ligand [Unconjugated]
255-SC/CF


Species Human
Applications BA

189 Publications
GM-CSF [Unconjugated]
7954-GM/CF
Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED<sub>50</sub> for this effect is 6-30 pg/mL.


Species Human
Applications BA

3 Publications
SAP155 Antibody
NBP2-47291
Western Blot: SAP155 Antibody [NBP2-47291] - Analysis in U2OS cells transfected with control siRNA, target specific siRNA probe #1 and #2. Remaining relative intensity is presented.Immunocytochemistry/Immunofluorescence: SAP155 Antibody [NBP2-47291] - Immunofluorescent staining of human cell line HeLa shows localization to nuclear speckles.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

Neutrophil Elastase/ELA2 [Biotin]
DY9167-05
Neutrophil Elastase/ELA2 [Biotin]


Species Human
Applications ELISA

15 Publications
G6PC3 Antibody
NBP3-03956
Western Blot: G6PC3 Antibody [NBP3-03956] - Analysis of extracts of 293T cells, using G6PC3 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit. Exposure time: 3s.Immunocytochemistry/Immunofluorescence: G6PC3 Antibody [NBP3-03956] - Immunofluorescence analysis of U2OS cells using G6PC3 Rabbit pAb (NBP3-03956) at dilution of 1:200 (40x lens). Blue: DAPI for nuclear staining.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF


Related Genes

Severe Congenital Neutropenia has been researched against:

Related Pathways

Severe Congenital Neutropenia has been linked to:

Related Diseases

Severe Congenital Neutropenia has been studied in relation to diseases such as:

Related PTMs

Severe Congenital Neutropenia has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Severe Congenital Neutropenia is also known as severe congenital neutropenia, infantile genetic agranulocytosis, neutropenia, severe congenital, kostmann's agranulocytosis, congenital agranulocytosis, neonatal hemochromatosis, congenital neutropenia, kostmann's syndrome, kostmanns syndrome, kostmann disease, agranulocytosis, neutropenia.