Hypercholesterolemia (also known as high cholesterol) occurs when abnormally high levels of certain types of cholesterol are in the blood (>5.2 mmol/L). This increase of cholesterol can cause plaque buildup in the artery walls, inevitably causing damage to organs and tissues when blood flow is restricted. Borderline hypercholesterolemia is defined when levels are between 200-239 mg/dL. Hypercholesterolemia is significantly correlated with increased incidence and risk of atherosclerosis, heart attack, and stroke. Risk is increased with smoking, diabetes, high blood pressure, obesity, and poor exercise in combination with a poor diet. Polygenic hypercholesterolemia is the most common cuase of elevated serum cholesterol concentrations because it is caused by multiple factors such as an atherogenic diet, obesity, and a sedentary lifestyle. Polygenic hypercholesterolemia, left untreated, significantly increases the risk for developing coronary heart disease (CHD). Treatment focuses on regulating and promoting a healthier, more active lifestyle for individuals with polygenic hypercholesterolemia. Medications may be used to assist in this process.
Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Polygenic Hypercholesterolemia below!
For more information on how to use Laverne, please read the How to Guide.
We have 706 products for the study of Polygenic Hypercholesterolemia that can be applied to Western Blot, Immunocytochemistry/Immunofluorescence, Flow Cytometry, Immunohistochemistry from our catalog of antibodies and ELISA kits.