Autoimmune Polyendocrinopathies are autoimmune diseases that affect multiple endocrine glands. There are two types of autoimmune polyendocrinopathies where type I is characterized by onset in the childhood and by mucocutaneous candidiasis while type II demonstrates adult onset without candidiasis and a combination of adrenal insufficiency (commonly Addison's diseases, autoimmune thyroiditis, hypothyroidism, and gonadal failure). Type II is associated with HLA-A1 and B8 haplotypes. Treatments for these conditions typically require addressing underlying conditions associated with autoimmune polyendocrinopathies.
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