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Nijmegen Breakage Syndrome: Disease Bioinformatics

Research of Nijmegen Breakage Syndrome has been linked to Malignant Neoplasms, Ataxia Telangiectasia, Ataxia, Immunologic Deficiency Syndromes, Microcephaly. The study of Nijmegen Breakage Syndrome has been mentioned in research publications which can be found using our bioinformatics tool below. Researched pathways related to Nijmegen Breakage Syndrome include Dna Repair, Cell Cycle, Hypersensitivity, Dna Replication, Double-strand Break Repair. These pathways complement our catalog of research reagents for the study of Nijmegen Breakage Syndrome including antibodies and ELISA kits against ATM, ATR, BRCA1, CDKN1A, H2AFX.

Nijmegen Breakage Syndrome Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Nijmegen Breakage Syndrome below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 1262 products for the study of Nijmegen Breakage Syndrome that can be applied to Western Blot, Chromatin Immunoprecipitation, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Chromatin Immunoprecipitation (ChIP) from our catalog of antibodies and ELISA kits.

NB100-143
Western Blot: Nbs1 Antibody [NB100-143] - TIG-1 human primary fibroblasts, whole cell lysate (30 ug). Image from verified customer review.Immunocytochemistry/Immunofluorescence: Nbs1 Antibody [NB100-143] - Hela cells. Image from verified customer review.

Rabbit Polyclonal
Species Human, Mouse, Hamster
Applications WB, ChIP, Flow

     8 Reviews

146 Publications
NB100-56155
Western Blot: NLRP2/NALP2 Antibody [NB100-56155] - Analysis of NLRP2/NALP2 using antibody at 1:2000. HEK293T: mock transfected cells, HEK293T-NALP2:NALP2 transiently transfected cells; THP-1: untreated cells; THP1-LPS: cells treated with 1 ug/ml LPS for4h. MCF-7: untreated cells.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

1 Publication
AF2589

Goat Polyclonal
Species Human
Applications WB, IHC

4 Publications
NB100-142
Western Blot: Mre11 Antibody [NB100-142] - Analysis of Mre11 on 50 ug of HeLa and MEF lysates, using NB100-142.Immunocytochemistry/Immunofluorescence: Mre11 Antibody [NB100-142] - HeLa cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.5% Triton-X100. The cells were incubated with anti-Mre11 [NB100-142] at a 1:500 dilution overnight at 4C and detected with an anti-rabbit Dylight 488 (Green) at a 1:500 dilution.  Actin was detected with Phalloidin 568 (Red) at a 1:200 dilution.  Nuclei were counterstained with DAPI (Blue).  Cells were imaged using a 40X objective.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, ChIP

     4 Reviews

145 Publications
NB100-104
Western Blot: ATM Antibody [NB100-104] - Detection of ATM in HeLa nuclear extract using NB100-104. (30 sec. exposure)Immunocytochemistry/Immunofluorescence: ATM Antibody [NB100-104] - HeLa cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.05% Triton-X100. Then cells were incubated with anti-ATM (NB100-104) at a 1:100 dilution overnight at 4C and detected with an anti-rabbit Dylight 488 (Green) at a 1:500 dilution. Alpha tubulin was used as a co-stain at a 1:1000 dilution and detected with an anti-mouse Dylight 550 (Red) at a 1:500 dilution. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 40X objective.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ELISA, Flow

     2 Reviews

74 Publications
NB100-147
Western Blot: Rad50 Antibody (13B3) [NB100-147] - HeLa whole cell and nuclear extracts (30 ug) were separated by 5% SDS-PAGE, and the membrane was blotted with Rad50 antibody [N1N2], N-term diluted at 1:500.Immunocytochemistry/Immunofluorescence: Rad50 Antibody (13B3) [NB100-147] - HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: Rad50 protein stained by Rad50 antibody [13B3]  diluted at 1:200. Red: phalloidin, a cytoskeleton marker, diluted at 1:200. Scale bar = 10um.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

     1 Review

73 Publications
H00004830-M02
Western Blot: NM23-H1 Antibody (1D7) [H00004830-M02] - NME1 monoclonal antibody (M02), clone 1D7. Analysis of NME1 expression in different cell lines.Immunocytochemistry/Immunofluorescence: NM23-H1 Antibody (1D7) [H00004830-M02] - Analysis of monoclonal antibody to NME1 on HeLa cell. Antibody concentration 10 ug/ml.

Mouse Monoclonal
Species Human
Applications WB, ELISA, ICC/IF

1 Publication
MAB1489
Western blot shows lysates of MCF‑7 human breast cancer cell line untreated (-) or treated (+) with 1 µM Camptothecin (CPT) for 5 hours. PVDF membrane was probed with 1:1000 dilution of Rabbit Anti-Human Phospho-p53 (S46) Monoclonal Antibody (Catalog # MAB1489) followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # <A class=NoLineLink href=

Rabbit Monoclonal
Species Human
Applications WB

NB100-384
Western Blot: gamma H2AX [p Ser139] Antibody [NB100-384] - Detection of Human and Mouse gamma H2AX by Western Blot. Samples: Nuclear extract (50 ug) from human HEK293, human melanoma (G361), mouse wildtype embryonic fibroblasts (+/+) or mouse H2AX knockout embryonic fibroblasts (-/-). Antibody: Affinity purified rabbit anti-gamma H2AX antibody NB100-384 used at 0.1 ug/ml. Detection: Chemiluminescence with 30 second exposure. (NCS, neocarzinostatin - 200 ng/ml, 30 min).Immunocytochemistry/Immunofluorescence: gamma H2AX [p Ser139] Antibody [NB100-384] - Samples: Neocarzinostatin treated asynchronous HeLa cells (left) and untreated asynchronous HeLa cells (right). Antibody: Affinity purified rabbit anti-gamma-H2AX used at a dilution of 1:5,000  (0.2ug/ml).  Detection: Red fluorescent Anti-rabbit IgG-DyLight 594 conjugatedused at a dilution of 1:100.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications IP (-), WB, Simple Western

     1 Review

62 Publications
MAB1626
    Chk2phosphorylated at T68 was detected in immersion fixed HeLa human cervical epithelial carcinoma cell  line unstimulated (lower panel) or stimulated with 1 μM Camptothecin (upper  panel) using Rabbit Anti-Human Phospho-Chk2 (T68) Monoclonal Antibody  (Catalog # MAB1626) at 2 µg/mL for 3 hours at room  temperature. Cells were stained using the NorthernLights™  557-conjugated Anti-Rabbit IgG Secondary Antibody (red; Catalog #  <a class=    Western  blot shows lysates of HeLa human cervical epithelial carcinoma cell line  untreated (-) or treated (+) with 1  μM Camptothecin (CPT) for 5 hours. PVDF  membrane was probed with 2 µg/mL of Rabbit Anti-Human Phospho-Chk2  (T68) Monoclonal Antibody (Catalog # MAB1626) followed by HRP-conjugated  Anti-Rabbit IgG Secondary Antibody (Catalog # <a class=

Rabbit Monoclonal
Species Human
Applications WB, ICC

NBP1-41185
Western Blot: BRCA1 Antibody (17F8) [NBP1-41185] -  A: 293T B: HeLa.Chromatin Immunoprecipitation: BRCA1 Antibody (17F8) [NBP1-41185] - ChIP grade BRCA1 antibody 6B4  and BRCA1 antibody 17F8 were used for ChIP assay. The 6B4 and 17F8 mixture (3 microgram each), or normal mouse IgG (6 microgram) were incubated with HeLa chromatin extract (100 umicrogram each) in the ChIP assay. Enrichment of genomic DNA on a BRCA1 target gene promoter (HMGA2) was validated by a Q-PCR assay.

Mouse Monoclonal
Species Human, Mouse
Applications WB, ChIP, ELISA

9 Publications
NBP2-03417
Western Blot: MMAB Antibody (2G5) [NBP2-03417] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MMAB (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MMAB.Immunohistochemistry-Paraffin: MMAB Antibody (2G5) [NBP2-03417] Staining of paraffin-embedded Human lymph node tissue using anti-MMAB mouse monoclonal antibody.

Mouse Monoclonal
Species Human
Applications WB, Flow, IHC

NB100-308
Western Blot: ATR Antibody (2B5) [NB100-308] - Raji whole cell and nuclear extracts (30 ug) were separated by 5% SDS-PAGE, and the membrane was blotted with ATR antibody diluted at 1:500.Immunocytochemistry/Immunofluorescence: ATR Antibody (2B5) [NB100-308] - Analysis of HeLa, using antibody at 1:100 dilution.

Mouse Monoclonal
Species Human
Applications WB, Func, ICC/IF

17 Publications
NB100-56585
Western Blot: TEM8/ANTXR1 Antibody (200C1339(SB20)) [NB100-56585] - Analysis of human heart lysates (35ug per lane, RIPA buffer) using TEM8 antibody (NB100-56585) at 0.3ug/ml. Band observed at 65kDa. (Expected MW of 62.8kDa according to NP_115584.1).Immunohistochemistry-Paraffin: TEM8/ANTXR1 Antibody (200C1339(SB20)) [NB100-56585] - Detection of TEM8/ANTXR1 in human liver cancer section using 5 ug/ml concentration of TEM8 antibody. Uniform weak staining was observed in the cancerous cells, while the blood vessels depicted the expected intense positivity for TEM8.

Mouse Monoclonal
Species Human
Applications WB, ICC/IF, IHC

4 Publications
NBP2-29463
Immunohistochemistry-Paraffin: p21/CIP1/CDKN1A Antibody (WA-1 (HJ21)) [NBP2-29463] - Formalin-fixed, paraffin-embedded human bladder carcinoma stained with p21 Monoclonal Antibody (WA-1).

Mouse Monoclonal
Species Human, Mouse, Rat
Applications Flow, ICC/IF, IHC

9 Publications
NB110-57379
Western Blot: DNA Ligase IV Antibody [NB110-57379] - Western blot on Hep G2 cell lysate stained with NB110-57379 at 1.25ug/ml.Immunohistochemistry: DNA Ligase IV Antibody [NB110-57379] - Immunohistochemical staining of human pancreatic tissue using NB110-57379 at a concentration of 5 ug/ml.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

2 Publications
NB100-148
Western Blot: Rad51 Antibody (14B4) [NB100-148] - Various whole cell extracts (30 ug) were separated by 10% SDS-PAGE, and the membrane was blotted with Rad51 antibody [14B4]  diluted at a dilution of 1:500 and developed with Trident Sharp-ECL. Immunocytochemistry/Immunofluorescence: Rad51 Antibody (14B4) [NB100-148] - staning of RAD51 nuclear foci in U2OS cells using RAD51 14B4 antibody. Cells were pre-extracted with CSK buffer before fixation with 4% PFA. RAD51 14B4 was used at 1:1000 dultion. DAPI was used to counterstain the nucleus. Scale bar, 10 mciro-meter.

Mouse Monoclonal
Species Human, Mouse, C. elegans
Applications WB, ICC/IF, IHC

     3 Reviews

31 Publications
NB100-204
Western Blot: SMC1 Antibody [NB100-204] - Detection of human SMC1 in HeLa nuclear extracts (50 ug), Xenopus oocytes (100 ug), and MEF whole cell lysate (100 ug) in Western blot using NB 100-204.Immunohistochemistry-Paraffin: SMC1 Antibody [NB100-204] - Sample: FFPE section of human breast carcinoma.

Rabbit Polyclonal
Species Human, Mouse, Xenopus
Applications WB, Simple Western, ELISA

32 Publications
NBP2-22128
Western Blot: DNA PKcs Antibody (3H6) [NBP2-22128] - Western blot image of DNA PKcs.  HeLa (lane A), MCF7 (lane B) and HEK293 (lane C) whole cell protein was separated by SDS-PAGE on 6% gel, transferred to PVDF and probed with NBP2-22128. A single band of DNA PKcs reactivity at approximately 460 kDa was detected in all lysates.Immunocytochemistry/Immunofluorescence: DNA PKcs Antibody (3H6) [NBP2-22128] - Immunofluorescence analysis of Hela cells using DNA PKcs mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.

Mouse Monoclonal
Species Human
Applications WB, ELISA, ICC/IF

NB100-304
Western Blot: 53BP1 Antibody [NB100-304] - Detection of 53BP1 by Western Blot Sample: Whole cell lysate from U2OS or 293T cells.Immunocytochemistry/Immunofluorescence: 53BP1 Antibody [NB100-304] - 53BP1 antibody was tested at 1:100 in HeLa cells with FITC (green). alpha-Tubulin antibody NB100-690 was tested at a 1:500 dilution using Mouse IgG secondary Antibody NB710-94914 at 1:1000 [HiLyte Fluor 555] (red). Nuclei were counterstained with Dapi (blue).

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ChIP, Flow

     5 Reviews

227 Publications

Related Genes

Nijmegen Breakage Syndrome has been researched against:

Related PTMs

Nijmegen Breakage Syndrome has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Nijmegen Breakage Syndrome is also known as nijmegen breakage syndrome, berlin breakage syndrome, seemanova syndrome, microcephaly with normal intelligence immunodeficiency and lymphoreticular malignancies, nonsyndromal microcephaly autosomal recessive with normal intelligence, microcephaly, normal intelligence and immunodeficiency (disorder), immunodeficiency, microcephaly with normal intelligence, microcephaly immunodeficiency lymphoreticuloma, ataxia-telangiectasia variant v1, immunologic deficiency syndromes, seemanova syndrome 2, at - v1.