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Neurofibrillary Tangles: Disease Bioinformatics

Research of Neurofibrillary Tangles has been linked to Alzheimer's Disease, Dementia, Senile Plaques, Plaque, Amyloid, Neurodegenerative Disorders. The study of Neurofibrillary Tangles has been mentioned in research publications which can be found using our bioinformatics tool below. Researched pathways related to Neurofibrillary Tangles include Pathogenesis, Aging, Hyperphosphorylation, Cell Death, Localization. These pathways complement our catalog of research reagents for the study of Neurofibrillary Tangles including antibodies and ELISA kits against ACHE, APOE, APP, CA1, CDK5.

Neurofibrillary Tangles Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Neurofibrillary Tangles below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 1086 products for the study of Neurofibrillary Tangles that can be applied to Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.

NBP2-25162
Western Blot: Tau Antibody (2E9) [NBP2-25162] - Blots of crude rat brain extract, revealing, as expected, multiple bands in the range 48-67kDa.Immunocytochemistry/Immunofluorescence: Tau Antibody (2E9) [NBP2-25162] - E18 primary rat hippocampal neurons (from Neuromics) were fixed and immunostained with NBP2-25162 (green), chicken antibody to alpha Internexin (NBP1-05208, red) and for DNA (blue). NBP2-25162 stains the neuronal perikarya and processes strongly, and does not stain non neuronal cells in these cultures. The alpha Internexin antibody stains intermediate or 10nm filament bundles in the cytoplasm of these cells.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF

NBP2-13075
Western Blot: beta Amyloid Antibody (MOAB-2) [NBP2-13075] - Western blot analysis in cell lysates from HEK-APP SWE/BACE1 cells probed with an antibody against the C-terminus of APP (Lanes 1 and 2) and beta Amyloid  (MOAB-2, Lanes 3 and 4).  Beta Amyloid (MOAB-2) does not detect APP (from PMID: 22423893).Immunocytochemistry/Immunofluorescence: beta Amyloid Antibody (MOAB-2) [NBP2-13075] - Immunofluorescent detection of beta Amyloid with MOAB-2 in the subiculim of 1-, 2- and 4- month old 5xFAD mice.  Scale bar 20 um (from PMID: 22423893).

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, ICC/IF

9 Publications
NB300-749
Western Blot: Presenilin-1 Antibody (APS 11) [NB300-749] - Analysis of 25 ug of SH-SY5Y (lane 1), human brain (lane 2) and mouse brain (lane 3).Immunocytochemistry/Immunofluorescence: Presenilin-1 Antibody (APS 11) [NB300-749] - Mouse fibroblasts.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, ICC/IF

     1 Review

1 Publication
NB110-60531
Western Blot: ApoE Antibody (WUE-4) [NB110-60531] - 50 ug protein per lane for liver lysate and 0.5 ul of plasma at 9% SDS. Samples are loaded onto the gel as the following order: human liver lysate, mouse liver lysate, rat liver lysate, human plasma, and mouse plasma. Image from confirmed customer review.Immunocytochemistry/Immunofluorescence: Apolipoprotein E/ApoE Antibody (WUE-4) [NB110-60531] - HepG2 cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.5% Triton-X100. The cells were incubated with anti-ApoE (WUE-4) [NB110-60531] at a 1:200 dilution overnight at 4C and detected with an anti-mouse Dylight 488 (Green) at a 1:500 dilution. Actin was detected with Phalloidin 568 (Red) at a 1:200 dilution. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 40X objective.

Mouse Monoclonal
Species Human, Mouse, Rat (Negative)
Applications WB, ELISA, Flow

     2 Reviews

9 Publications
NBP1-26380
Western Blot: Synuclein-alpha [Nitrate Tyr125, Nitrate Tyr133] Antibody (24.8) [NBP1-26380] - Western blot of (A) Nitrated Synuclein-alpha protein and (B) non-nitrated Synuclein-alpha protein.Immunohistochemistry-Paraffin: alpha-Synuclein [Nitrate Tyr125, Nitrate Tyr133] Antibody (24.8) [NBP1-26380] - IHC analysis of formalin fixed paraffin-embedded (FFPE) human brain using alpha-Synuclein antibody (clone 24.8) at 1:200 on a Bond Rx autostainer (Leica Biosystems). The assay involved 20 minutes of heat induced antigen retrieval (HIER) using 10mM sodium citrate buffer (pH 6.0) and endogenous peroxidase quenching with peroxide block. The sections were incubated with primary antibody for 30 minutes and Bond Polymer Refine Detection (Leica Biosystems) with DAB was used for signal development followed by counterstaining with hematoxylin. Whole slide scanning and capturing of representative images was performed using Aperio AT2 (Leica Biosystems). Cytoplasmic puncta and varicosities staining was observed. Staining was performed by Histowiz.

Mouse Monoclonal
Species Human, Mouse
Applications WB, Flow, ICC/IF

2 Publications
AF2180
    Simple  Western lane view shows lysates of HEL 92.1.7 human erythroleukemic  cell line and human liver tissue, loaded at 0.2 mg/mL. A specific  band was detected for Carbonic Anhydrase I/CA1 at approximately  38 kDa (as indicated) using 5 µg/mL of Goat Anti-Human  Carbonic Anhydrase I/CA1 Antigen Affinity-purified Polyclonal  Antibody (Catalog # AF2180) followed by 1:50 dilution of HRP-conjugated  Anti-Goat IgG Secondary Antibody (Catalog # <a class=    Western  blot shows lysates of HEL 92.1.7 human erythroleukemic cell line,  human liver tissue, and human colon tissue. PVDF membrane was probed with  0.1 µg/mL of Goat Anti-Human Carbonic Anhydrase I/CA1  Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2180) followed by  HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class=

Goat Polyclonal
Species Human
Applications WB, Simple Western, IP

NBP2-15843
Western Blot: Cdk5 Antibody [NBP2-15843] - Sample (50 ug of whole cell lysate)  A: mouse brain 12% SDS PAGE  diluted at 1:1000 Immunocytochemistry/Immunofluorescence: Cdk5 Antibody [NBP2-15843] - Immunofluorescence analysis of paraformaldehyde-fixed A549, using antibody at 1:200 dilution.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

NBP2-22449
Western Blot: Acetylcholinesterase/ACHE Antibody (ZR3) [NBP2-22449] - Western blot analysis was performed on whole cell extracts (30 ug lysate) of Mouse Brain (lane 1), HeLa (lane 2), SK-N-SH (lane 3) and U-87 MG (lane 4).Immunocytochemistry/Immunofluorescence: Acetylcholinesterase/ACHE Antibody (ZR3) [NBP2-22449] - Analysis of Acetylcholinesterase using Acetylcholinesterase Monoclonal antibody (ZR3) shows staining in U251 glioma cells. Acetylcholinesterase staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing Acetylcholinesterase at a dilution of 1:20 over night at 4C, washed with PBS and incubated with a DyLight-488 conjugated.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, Flow

215-GM/CF
1 μg/lane of Recombinant Human GM-CSF was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 14 kDa.Recombinant Human GM-CSF (Catalog # 215-IL/CF) stimulates cell proliferation of the TF-1 human erythroleukemic cell line. The ED<sub>50</sub> for this effect is 6-30 pg/mL.


Species Human

181 Publications
NBP2-42388
Western Blot: LAMC2 Antibody (CL2980) [NBP2-42388] - Analysis in human cell line A-431.Immunohistochemistry-Paraffin: LAMC2 Antibody (CL2980) [NBP2-42388] - Staining of human lymph node shows absence of immunoreactivity in lymphoid tissue (negative control).

Mouse Monoclonal
Species Human
Applications WB, IHC, IHC-P

AF4937
Western blot shows lysates of human pancreas tissue. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human Reg1A Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4937) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # <a class=Reg1A was detected in immersion fixed paraffin-embedded sections of human pancreas using Sheep Anti-Human Reg1A Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4937) at 3 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # <A class=NoLineLink href=

Sheep Polyclonal
Species Human
Applications WB, IHC

NB100-74512
Western Blot: Presenilin-2 Antibody (APS 21) [NB100-74512] - Analysis of 25 ug of SH-SY5Y (lane 1), human brain (lane 2) and PC12 (lane 3).Immunocytochemistry/Immunofluorescence: Presenilin-2 Antibody (APS 21) [NB100-74512] - Presenilin- 2 staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing Presenilin 2 at a dilution of 1:100 over night at 4C, washed with PBS and incubated with a DyLight-488 conjugated.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, ICC/IF

AF5659
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Goat Polyclonal
Species Human
Applications WB

NBP2-37493
Western Blot: PSP/BPIFA2 Antibody (1F12) [NBP2-37493] - Western blot analysis using mouse Splunc2 mAb against mouse Splunc2 (AA: 16-169) recombinant protein. (Expected MW is 41.6 kDa)Immunocytochemistry/Immunofluorescence: PSP/BPIFA2 Antibody (1F12) [NBP2-37493] - Immunofluorescence analysis of HepG2 cells using mouse Splunc2 mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.

Mouse Monoclonal
Species Human, Mouse
Applications WB, ELISA, Flow

NBP1-82452
Western Blot: HRSP12 Antibody [NBP1-82452] - Lane 1: Mouse liver tissue lysate Lane 2: Rat liver tissue lysateImmunohistochemistry-Paraffin: HRSP12 Antibody [NBP1-82452] - Staining of human kidney shows moderate positivity in tubules.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC, IHC-P

1 Publication
NBP2-02450
Western Blot: Prostate Secretory Protein/PSP Antibody (6C7) [NBP2-02450] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY Prostate Secretory Protein/PSP (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-Prostate Secretory Protein/PSP.Immunocytochemistry/Immunofluorescence: Prostate Secretory Protein/PSP Antibody (6C7) [NBP2-02450] Staining of COS7 cells transiently transfected by pCMV6-ENTRY Prostate Secretory Protein/PSP.

Mouse Monoclonal
Species Human
Applications WB, ICC/IF, IHC

MAB2388

Mouse Monoclonal
Species Human
Applications WB, IHC

NBP1-56848
Western Blot: Phosphoserine phosphatase Antibody [NBP1-56848] - Analysis of PSPH in human PSPH overexpressed glioma (Lane1) and non-transfected (Lane2) cells using anti-PSPH (Phosphoserine phosphatase) antibody. Image from verified customer review.Western Blot: Phosphoserine phosphatase Antibody [NBP1-56848] - Human Heart lysate, concentration 0.2-1 ug/ml.

Rabbit Polyclonal
Species Human
Applications WB

     1 Review

1 Publication
NB300-141
Immunocytochemistry/Immunofluorescence: GFAP Antibody [NB300-141] - ICC-IF analysis of mixed neuron-glial cultures using GFAP antibody NB300-141 (red) and Vimentin antibody NB300-223 (green). The fibroblastic cells contain only Vimentin and so are green.  The astrocytes contain either Vimentin and GFAP (appearing golden) or predominantly GFAP (appearing red). Blue is nuclear DNA stain.Immunocytochemistry/Immunofluorescence: GFAP Antibody [NB300-141] - Rat neurons stained with Neurofilament Heavy antibody NB300-217 (red) and GFAP antibody NB300-141 (green).

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, ICC/IF

     4 Reviews

32 Publications
NBP1-59744
Western Blot: gamma Sarcoglycan Antibody [NBP1-59744] - Lane 1 mouse Heart; 2 mouse Liver (expected negative); 3 mouse Liver; 4 mouse Quadriceps; 5 mouse Triceps; 6 mouse Triceps; 7 mouse Triceps. All lanes 25ug mouse protein. Image from verified customer review.Immunohistochemistry-Frozen: gamma Sarcoglycan Antibody [NBP1-59744] - Mouse tibialis anterior frozen sections. Image from verified customer review.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, IHC, IHC-Fr

     2 Reviews


Related Genes

Neurofibrillary Tangles has been researched against:

Alternate Names

Neurofibrillary Tangles is also known as Alzheimer's Neurofibrillary Change, Alzheimer's Neurofibrillary Degeneration, Neurofibrillary Degeneration, Neurofibrillary Tangle, Nft.