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Myoclonic Epilepsy, Juvenile: Disease Bioinformatics

Epilepsy is defined as a diverse set of neurological disorders characterized by seizures. These seizures occur due to abnormal electrical activity in the brain. Factors that may lead to epilepsy include, but are not limited to, brain trauma, gene mutations, strokes, brain cancer, and extensive drug and alcohol use. Seizures occur due to a large release of glutamate, which causes a spread of excitation throughout the brain, which propagates the electrical signal and can lead to neuronal death. Myoclonic epilepsy is characterized by seizures that result in rapid, jerk-like movements and can affect the face, limbs, or axial musculature. Juvenile myoclonic epilepsy is an epilepsy syndrome characterized by myoclonic jerks, generalized tonic-clonic seizures, and sometimes, absence seizures. The EFHC1 gene is an important gene associated with juvenile myoclonic epilepsy. About 50 million people have epilepsy, with 80% of that population located in developing countries. It is possible to control epilepsy with medicine, but many cases may require surgery in order to relieve symptoms.

Myoclonic Epilepsy, Juvenile Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Myoclonic Epilepsy, Juvenile below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 600 products for the study of Myoclonic Epilepsy, Juvenile that can be applied to Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.

Scn1a Antibody
NBP2-58876
Immunocytochemistry/Immunofluorescence: Scn1a Antibody [NBP2-58876] - Staining of human cell line ASC TERT1 shows localization to nucleoplasm & plasma membrane. Antibody staining is shown in green.

Rabbit Polyclonal
Species Human
Applications ICC/IF

EFHC1 Antibody
H00114327-D01P
Western Blot: EFHC1 Antibody [H00114327-D01P] - Analysis of EFHC1 expression in mouse testis.Western Blot: EFHC1 Antibody [H00114327-D01P] - Analysis of EFHC1 expression in transfected 293T cell line by EFHC1 polyclonal antibody.Lane 1: EFHC1 transfected lysate(73.90 KDa).Lane 2: Non-transfected lysate.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ELISA

1 Publication
GABA-A R alpha 1 Antibody
NB300-191
Western Blot: GABA-A R alpha 1 Antibody [NB300-191] - Mouse forebrain lysates from Wild Type (WT) and alpha 1-knockout (K/O) animals showing specific immunolabeling of the -51 kDa alpha 1-subunit of the GABAA-R. The labeling was absent from a lysate prepared from alpha 1-knockout animals.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB

     1 Review

10 Publications
Nicotinic Acetylcholine R alpha 4/CHRNA4 Antibody (7B4H1)
NBP2-61674
Western Blot: Nicotinic Acetylcholine R alpha 4/CHRNA4 Antibody (7B4H1) [NBP2-61674] - Analysis using CHRNA4 mAb against HEK293 (1) and CHRNA4 (AA: 29-242)-hIgGFc transfected HEK293 (2) cell lysate.Flow Cytometry: Nicotinic Acetylcholine R alpha 4/CHRNA4 Antibody (7B4H1) [NBP2-61674] - Analysis using CHRNA4 mouse mAb against SH-SY5Y (1) cell lysate.

Mouse Monoclonal
Species Human
Applications WB, ELISA

BRD2 Antibody
NBP1-84310
Western Blot: BRD2 Antibody [NBP1-84310] - Analysis in human cell lines HEK293 and MCF-7 using Anti-BRD2 antibody. Corresponding BRD2 RNA-seq data are presented for the same cell lines. Loading control: Anti-HSP90B1.Immunocytochemistry/Immunofluorescence: BRD2 Antibody [NBP1-84310] - Staining of human cell line U-2 OS shows positivity in nucleus but not nucleoli.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

CLCN2 Antibody
NBP1-85585
Immunocytochemistry/Immunofluorescence: CLCN2 Antibody [NBP1-85585] - Staining of human cell line CACO-2 shows localization to cytosol. Antibody staining is shown in green.Immunohistochemistry-Paraffin: CLCN2 Antibody [NBP1-85585] - Staining of human testis shows strong cytoplasmic positivity in Leydig cells.

Rabbit Polyclonal
Species Human
Applications ICC/IF, IHC, IHC-P

Cystatin B/Stefin B Antibody [Unconjugated]
AF1408
Western blot shows lysates of human colon tissue, PC‑12 rat adrenal pheochromocytoma cell line, A549 human lung carcinoma cell line, and SK‑BR‑3 human breast cancer cell line. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Rat Cystatin B Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1408) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <A class=NoLineLink href=Simple Western lane view shows lysates of A549 human lung carcinoma cell line, loaded at 0.2 mg/mL. A specific band was detected for Cystatin B at approximately 18 kDa (as indicated) using 10 µg/mL of Goat Anti-Human/Rat Cystatin B Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1408) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class=

Goat Polyclonal
Species Human, Rat
Applications WB, Simple Western, IHC

1 Publication
Kv7.2 Antibody
NBP1-88645
Immunohistochemistry-Paraffin: Kv7.2 Antibody [NBP1-88645] - Staining of human cerebellum shows moderate nuclear membranous positivity in Purkinje cells.

Rabbit Polyclonal
Species Human
Applications IHC, IHC-P

     1 Review

POMC Antibody
NB100-1533
Western Blot: POMC Antibody [NB100-1533] - Western blot analysis of POMC using NB100-1533 at 0.01ug/ml in NIH 3T3 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry-Paraffin: POMC Antibody [NB100-1533] - Analysis in human Anterior Pituitary Gland shows vesilulate staining in glandular cells.

Goat Polyclonal
Species Human, Mouse, Porcine
Applications WB, ICC/IF, IHC

7 Publications
Thymidylate Synthase Antibody (SPM453)
NBP2-34390

Mouse Monoclonal
Species Human
Applications WB, Flow, ICC/IF

     1 Review

Kv7.3 Antibody
NBP1-74102
Western Blot: Kv7.3 Antibody [NBP1-74102] - Lanes: 100 ug CHO cell lysate Primary Antibody Dilution: 1 : 1000 Secondary Antibody: Goat anti-rabbit HRP Secondary Antibody Dilution: 1 : 25000 Gene name: Kcnq3 Submitted by: Anonymous.Western Blot: Kv7.3 Antibody [NBP1-74102] - Kv7.3 Antibody Titration: 1.0 ug/ml Positive Control: Mouse Heart.

Rabbit Polyclonal
Species Mouse, Chinese Hamster
Applications WB

1 Publication
ASC/TMS1 Antibody
NBP1-78977
Western Blot: ASC/TMS1 Antibody [NBP1-78977] - Western Blot Image of anti-ACS/TMS1. Whole cell protein from THP1 (lane 1) and HL60 (lane 2) was separated on a 4-15% gel by SDS-PAGE, transferred to 0.2 um PVDF membrane and blocked in 5% non-fat milk in TBST. The membrane was probed with 4.0 ug/ml anti-ACS/TMS1 in 1% milk, and detected with an anti-rabbit HRP secondary antibody using chemiluminescence.Immunocytochemistry/Immunofluorescence: ASC/TMS1 Antibody [NBP1-78977] - ASC/TMS1 antibody was tested in MCF-7 cells with FITC (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red).

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, ICC/IF

     2 Reviews

5 Publications
GABA-A R gamma 2 Antibody
NB300-151
Western Blot: GABA-A R gamma 2 Antibody [NB300-151] - 10 ug of rat brain lysate showing immunolabeling of the ~45-47 kDa GABA - A R, g2-subunit.Immunohistochemistry-Paraffin: GABA-A R gamma 2 Antibody [NB300-151] - Rat cerebellum.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

6 Publications
Aurora A Antibody
NBP1-51843
Western Blot: Aurora A Antibody [NBP1-51843] - WB detection of Aurora A in HeLa whole cell lysate.Immunocytochemistry/Immunofluorescence: Aurora A Antibody [NBP1-51843] - IF Confocal analysis of HeLa cells using Aurora A antibody (NBP1-51843, 1:10). An Alexa Fluor 488-conjugated Goat to rabbit IgG was used as secondary antibody (green). Actin filaments were labeled with Alexa Fluor 568 phalloidin (red). DAPI was used to stain the cell nuclei (blue).

Rabbit Polyclonal
Species Human, Mouse
Applications WB, Simple Western, ICC/IF

     1 Review

5 Publications
FATP4/SLC27A4 Antibody (342142) [Unconjugated]
MAB3650

Mouse Monoclonal
Species Human
Applications Flow, CyTOF-ready

ISYNA1 Antibody
NBP2-47415
Western Blot: ISYNA1 Antibody [NBP2-47415] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10<br/>Lane 2: Human cell line HEK 293Immunocytochemistry/Immunofluorescence: ISYNA1 Antibody [NBP2-47415] - Immunofluorescent staining of human cell line HEK 293 shows localization to nucleus & cytosol.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC


Related Genes

Myoclonic Epilepsy, Juvenile has been researched against:

Related Pathways

Myoclonic Epilepsy, Juvenile has been linked to:

Related Diseases

Myoclonic Epilepsy, Juvenile has been studied in relation to diseases such as:

Related PTMs

Myoclonic Epilepsy, Juvenile has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Myoclonic Epilepsy, Juvenile is also known as Adolescent Myoclonic Epilepsy, Epilepsy, Juvenile Myoclonic, Janz Syndrome, Jme (juvenile Myoclonic Epilepsy), Juvenile Myoclonic Epilepsies.