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Megalencephalic Leukoencephalopathy With Subcortical Cysts: Disease Bioinformatics

Research of Megalencephalic Leukoencephalopathy With Subcortical Cysts has been linked to Leukoencephalopathies, Macrocephaly, Central Nervous System Cysts, Dementia, Vascular, Leukodystrophy. The study of Megalencephalic Leukoencephalopathy With Subcortical Cysts has been mentioned in research publications which can be found using our bioinformatics tool below. Researched pathways related to Megalencephalic Leukoencephalopathy With Subcortical Cysts include Localization, Pathogenesis, Cell Adhesion, Brain Development, Endocytosis. These pathways complement our catalog of research reagents for the study of Megalencephalic Leukoencephalopathy With Subcortical Cysts including antibodies and ELISA kits against MLC1, MYL4, HEPACAM, CLCN2, AQP4.

Megalencephalic Leukoencephalopathy With Subcortical Cysts Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Megalencephalic Leukoencephalopathy With Subcortical Cysts below! For more information on how to use Laverne, please read the How to Guide.
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Top Research Reagents

We have 904 products for the study of Megalencephalic Leukoencephalopathy With Subcortical Cysts that can be applied to Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.

NBP1-81555
Western Blot: MLC1 Antibody [NBP1-81555] - Analysis in control (vector only transfected HEK293T lysate) and MLC1 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).Immunohistochemistry-Paraffin: MLC1 Antibody [NBP1-81555] - Staining in human cerebral cortex and pancreas tissues using anti-MLC1 antibody. Corresponding MLC1 RNA-seq data are presented for the same tissues.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

1 Publication
NBP2-30954
Western Blot: MYL4 Antibody [NBP2-30954] - Lane 1: Marker  [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10.  Lane 2: HELImmunocytochemistry/Immunofluorescence: MYL4 Antibody [NBP2-30954] - Staining of human cell line U-2 OS shows localization to plasma membrane. Antibody staining is shown in green.

Rabbit Polyclonal
Species Human
Applications WB, Simple Western, ICC/IF

MAB4108
Western blot shows lysates of human brain (motor cortex) tissue and human brain (hippocampus) tissue. PVDF membrane was probed with 0.25 µg/mL of Mouse Anti-Human HepaCAM Monoclonal Antibody (Catalog # MAB4108) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # <A class=NoLineLink href=

Mouse Monoclonal
Species Human
Applications WB

     1 Review

1 Publication
H00001181-M01
Western Blot: CLCN2 Antibody (3E1) [H00001181-M01] - CLCN2 monoclonal antibody (M01), clone 3E1 Analysis of CLCN2 expression in Hela S3 NE.Western Blot: CLCN2 Antibody (3E1) [H00001181-M01] - Analysis of CLCN2 over-expressed 293 cell line, cotransfected with CLCN2 Validated Chimera RNAi ( Cat # H00001181-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with CLCN2 monoclonal antibody (M01), clone 3E1 (Cat # H00001181-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.

Mouse Monoclonal
Species Human
Applications WB, ELISA, RNAi

NBP1-87679
Western Blot: Aquaporin-4 Antibody [NBP1-87679] - Analysis in human brain tissue.Immunocytochemistry/Immunofluorescence: Aquaporin-4 Antibody [NBP1-87679] - Staining of human cell line U-251 MG shows localization to plasma membrane. Antibody staining is shown in green.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

     1 Review

7 Publications
NBP1-20149
Western Blot: KCNJ10 Antibody [NBP1-20149] - WB on mouse tissue lysate. Blocking: 1% LFDM for 30 min at RT; primary antibody: dilution 1:3000 incubated at 4C overnight.Immunohistochemistry-Paraffin: KCNJ10 Antibody [NBP1-20149] - IHC-P on paraffin sections of rat brain. The animal was perfused using Autoperfuser at a pressure of 130 mmHg with 300 ml 4% FA before being processed for paraffin embedding. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 um. Detection was done using  HRP polymer following manufacturers instructions; DAB chromogen: Candela DAB chromogen from Osenses. Primary antibody: dilution 1: 2000, incubated 30 min at RT using Autostainer. Sections were counterstained with Harris Hematoxylin.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC, IHC-Fr

1 Publication
NBP2-03605
Western Blot: ACOT12 Antibody (1A11) [NBP2-03605] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ACOT12 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ACOT12.Immunohistochemistry-Paraffin: ACOT12 Antibody (1A11) [NBP2-03605] Staining of paraffin-embedded Human pancreas tissue using anti-ACOT12 mouse monoclonal antibody.

Mouse Monoclonal
Species Human
Applications WB, Flow, IHC

NBP1-89306
Western Blot: TNIP1 Antibody [NBP1-89306] - Analysis in U-87MG ATCC cells transfected with control siRNA, target specific siRNA probe #1 and #2,. Remaining relative intensity is presented. Loading control: Anti-GAPDH.Immunohistochemistry-Paraffin: TNIP1 Antibody [NBP1-89306] - Staining of human small intestine shows moderate  cytoplasmic positivity in glandular cells.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC, IHC-P

NBP1-32783
Western Blot: eIF2B epsilon Antibody [NBP1-32783] - Sample (30 ug of whole cell lysate)A: H12997. 5% SDS PAGE, antibody diluted at 1:1000.Immunocytochemistry/Immunofluorescence: eIF2B epsilon Antibody [NBP1-32783] - Paraformaldehyde-fixed A431, using antibody at 1:200 dilution.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ICC/IF

NB300-141
Immunocytochemistry/Immunofluorescence: GFAP Antibody [NB300-141] - Analysis of mixed neuron-glial cultures using GFAP antibody NB300-141 (red) and Vimentin antibody NB300-223 (green). The fibroblastic cells contain only Vimentin and so are green.  The astrocytes contain either Vimentin and GFAP (appearing golden) or predominantly GFAP (appearing red). Blue is nuclear DNA stain.Immunocytochemistry/Immunofluorescence: GFAP Antibody [NB300-141] - Rat neurons stained with Neurofilament Heavy antibody NB300-217 (red) and GFAP antibody NB300-141 (green).

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, ICC/IF

     6 Reviews

52 Publications
NB100-615
Western Blot: Caveolin-1 Antibody (7C8) [NB100-615] - Detection of caveolin in 3T3 cell lysates (50 ug). Lanes 1 and 2: 1:4000.  Lanes 3 and 4: 1:1000. Detection by ECL: 5 minute exposure.Immunocytochemistry/Immunofluorescence: Caveolin-1 Antibody (7C8) [NB100-615] - Subcellular localization of mPARM-1 and hPARM-1 (full-length and mutant proteins). NIH/3T3 cells transiently expressing hPARM-1-GFP or deltaCT-GFP were fixed, immunostained for caveolin-1 (1:100, Novus Biologicals), and examined by confocal fluorescence microscopy. For hPARM-1-GFP-caveolin-1 co-localization, cells that  demonstrated cell membrane PARM-1 localization were chosen. All co-localizations were observed following merging images of GFP-tagged proteins with those of Golgi, endosomes, plasma membrane, alpha-tubulin or caveolin-1 labeling. Image collected and cropped by CiteAb from the following publication (http://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-12-84), licensed under a CC-BY licence.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, Flow, IB

     2 Reviews

25 Publications
NBP1-84725
Western Blot: Fibulin 1 Antibody [NBP1-84725] - Analysis in control (vector only transfected HEK293T lysate) and FBLN1 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).Immunohistochemistry-Paraffin: Fibulin 1 Antibody [NBP1-84725] - Staining in human cervix, uterine and liver tissues using anti-FBLN1 antibody. Corresponding FBLN1 RNA-seq data are presented for the same tissues.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

     1 Review

4 Publications
NBP2-67416
Western Blot: Integrin beta 3/CD61 Antibody (SJ19-09) [NBP2-67416] - Mouse bone marrow cell lysate with DMSO (lane 1), chemical agonist #1 (lane 2), chemical agonist #2 (lane 3), chemical agonist #3 (lane 4). WB image submitted by a verfied customer review.Immunocytochemistry/Immunofluorescence: Integrin beta 3/CD61 Antibody (SJ19-09) [NBP2-67416] - Staining Integrin beta 3 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilized with 0.25% Triton X-100/PBS.

Rabbit Monoclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

     2 Reviews

NBP2-24716
Western Blot: MTSS1 Antibody [NBP2-24716] - Analysis of MTSS1 in human testis lysate in the 1) absence and 2) presence of immunizing peptide, 3) mouse and 4) rat testis lysate using NBP2-24716 at 2 ug/ml, 4 ug/ml and 2 ug/ml, respectively.Immunohistochemistry-Paraffin: MTSS1 Antibody [NBP2-24716] - Analysis of human colon using this antibody at 10 ug/ml.

Rabbit Polyclonal
Species Human, Mouse, Primate
Applications WB, ICC/IF, IHC

1 Publication
NB100-612
Western Blot: Rictor Antibody [NB100-612] - Whole cell lysate (50 ug) from HeLa, HEK293T, and Jurkat cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-Rictor antibody  used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.Knockdown Validated: Rictor Antibody [NB100-612] - SERCA2A expression is regulated by mTORC2. Rictor silencing was induced by cell transfection with rictor siRNA and then, cells were stimulated with IGF-1 for 24 hours in presence or absence of E2. mTORC2 downregulation was confirmed by abolished Akt-pS473 and resulted in decreased SERCA2A protein expression. Akt-pT308, mTOR and raptor were not negatively affected by rictor silencing. Pictured are representative western blots.  Image collected and cropped by CiteAb from the following publication (http://dx.plos.org/10.1371/journal.pone.0123385), licensed under a CC-BY licence.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ICC/IF, IHC

     2 Reviews

20 Publications
NBP1-83854
Western Blot: DARS2 Antibody [NBP1-83854] - Analysis using Anti-DARS2 antibody NBP1-83854 (A) shows similar pattern to independent antibody NBP1-83855 (B).Immunocytochemistry/Immunofluorescence: DARS2 Antibody [NBP1-83854] - Staining of human cell line A-431 shows localization to nucleoplasm & mitochondria.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

NBP1-84581
Western Blot: Integrin alpha 2b/CD41 Antibody [NBP1-84581] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10  Lane 2: Human cell line HELImmunohistochemistry-Paraffin: Integrin alpha 2b/CD41 Antibody [NBP1-84581] - Staining of human bone marrow shows strong cytoplasmic positivity in megakaryocytes.

Rabbit Polyclonal
Species Human
Applications WB, Simple Western, IHC

NBP2-42388
Western Blot: LAMC2 Antibody (CL2980) [NBP2-42388] - Analysis in A-431 cells transfected with control siRNA, target specific siRNA probe #1 and #2, using Anti-LAMC2 antibody. Remaining relative intensity is presented. Loading control: Anti-GAPDH.Immunocytochemistry/Immunofluorescence: LAMC2 Antibody (CL2980) [NBP2-42388] - Staining of A-431 cells using the Anti-LAMC2 monoclonal antibody, showing specific staining in the cytosol in green. Microtubule- and nuclear probes are visualized in red and blue, respectively (where available).

Mouse Monoclonal
Species Human
Applications WB, ICC/IF, IHC

2 Publications
NBP1-85047
Knockout Validated: Tight Junction Protein 1 Antibody [NBP1-85047] - Western blot shows lysates of HeLa human cervical epithelial carcinoma parental cell line and TJP1 knockout (KO) HeLa cell line. PVDF membrane was probed with 1:200 of Rabbit Anti-Human TJP1 Polyclonal Antibody (Catalog # NBP1-85047) followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog #HAF008). Specific band was detected for TJP1 at approximately 260 kDa (as indicated) in the parental HeLa cell line, but is not detectable in the knockout HeLa cell line. This experiment was conducted under reducing conditions.Western Blot: Tight Junction Protein 1 Antibody [NBP1-85047] - Analysis in human cell line A-431.

Rabbit Polyclonal
Species Human, Mouse, Porcine
Applications WB, Simple Western, ICC/IF

     4 Reviews

5 Publications
NBP1-82120
Western Blot: CYREN Antibody [NBP1-82120] - Analysis in control (vector only transfected HEK293T lysate) and C7orf49 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).Immunocytochemistry/Immunofluorescence: CYREN Antibody [NBP1-82120] - Staining of human cell line U-251 MG shows localization to the Golgi apparatus. Antibody staining is shown in green.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC


Related Genes

Megalencephalic Leukoencephalopathy With Subcortical Cysts has been researched against:

Related Pathways

Megalencephalic Leukoencephalopathy With Subcortical Cysts has been linked to:

Related PTMs

Megalencephalic Leukoencephalopathy With Subcortical Cysts has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Megalencephalic Leukoencephalopathy With Subcortical Cysts is also known as megalencephalic leukoencephalopathy with subcortical cysts, vacuolating megalencephalic leukoencephalopathy with subcortical cysts, mlc, lvm, leukoencephalopathy with swelling and a discrepantly mild course, infantile leukoencephalopathy and megalencephaly, megalencephaly-cystic leukodystrophy, vacuolating leukoencephalopathy, van der knapp disease, leukoencephalopathies, derivative chromosome, leukodystrophies, leukodystrophy, vl.