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Leigh Disease: Disease Bioinformatics

Research of Leigh Disease has been linked to Mitochondrial Diseases, Encephalopathies, Cytochrome-c Oxidase Deficiency, Acidosis, Acidosis, Lactic. The study of Leigh Disease has been mentioned in research publications which can be found using our bioinformatics tool below. Researched pathways related to Leigh Disease include Oxidative Phosphorylation, Pathogenesis, Translation, Transport, Localization. These pathways complement our catalog of research reagents for the study of Leigh Disease including antibodies and ELISA kits against MT-ATP6, ATP5E, COX8A, CPOX, CSF2.

Leigh Disease Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Leigh Disease below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 427 products for the study of Leigh Disease that can be applied to Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.

NB100-56503
Western Blot: Cytochrome c Antibody (7H8.2C12) [NB100-56503] - Analysis using the Biotin conjugate of NB100-56503. Detection of Cytochrome C in 15 mgs of HeLa cell lysate using NB100-55775 at 1:1000. A 15 kDa band is detected.Immunocytochemistry/Immunofluorescence: Cytochrome c Antibody (7H8.2C12) [NB100-56503]

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, Flow, ICC/IF

46 Publications
NBP1-32550
Western Blot: COX5A Antibody [NBP1-32550] - Sample(30 ug whole cell lysate)A:HeLa S3 B:Hep G2 15% SDS PAGE, antibody diluted at 1:5000.Immunocytochemistry/Immunofluorescence: COX5A Antibody [NBP1-32550] -  A431.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ICC/IF, IHC

2 Publications
NBP2-59438
Western Blot: CPOX Antibody (36B10) [NBP2-59438] - Lane 1: Recombinant protein CPOX, Lane 2: 293T cell lysates, Lane 3: HepG2 cell lysates, Lane 4: A549 cell lysates, Lane 5: Jurkat cell lysates, Lane 6: K562 cell lysates, Lane 7: LnCaP cell lysatesImmunocytochemistry/Immunofluorescence: CPOX Antibody (36B10) [NBP2-59438] - Analysis of CPOX in Hep3B cells line, stained with DAPI (Blue) for nucleus staining and monoclonal anti-human CPOX antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green).

mouse Monoclonal
Species Human
Applications WB, ELISA, Flow

NBP2-30764
Immunohistochemistry: COX8A Antibody [NBP2-30764] - Staining of human skin shows strong cytoplasmic positivity in keratinocytes.

Rabbit Polyclonal
Species Human
Applications IHC, IHC-P

H00006834-T01
Lane 1: SURF1 transfected lysate (33.11 KDa) Lane 2: Non-transfected lysate.SURF1 transfected lysate.


Species Human

NBP1-82845
Western Blot: LIAS Antibody [NBP1-82845] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells). Lane 2: NBT-II cell lysate (Rat Wistar bladder tumor cells).Immunocytochemistry/Immunofluorescence: LIAS Antibody [NBP1-82845] - Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & mitochondria.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

NBP1-32744
Western Blot: LRPPRC Antibody [NBP1-32744] - Sample (30 ug of whole cell lysate) A: H1299 B: HeLa 5% SDS PAGE, antibody diluted at 1:1000.Immunocytochemistry/Immunofluorescence: LRPPRC Antibody [NBP1-32744] - Paraformaldehyde-fixed HeLa, using antibody at 1:200 dilution.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ICC/IF, IHC

1 Publication
NBP1-31302
Western Blot: Dihydrolipoamide Dehydrogenase/DLD Antibody [NBP1-31302] - Various whole cell extracts (30 ug) were separated by 10% SDS-PAGE, and the membrane was blotted with DLD antibody diluted at 1:1000.Immunocytochemistry: Dihydrolipoamide Dehydrogenase/DLD Antibody [NBP1-31302] - Analysis of methanol-fixed Hep3B, using antibody at 1:100 dilution.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

     1 Review

NBP1-33633
Western Blot: DNA Polymerase gamma Antibody [NBP1-33633] - Sample (30 ug of whole cell lysate) A: MCF-7 5% SDS PAGE; antibody diluted at 1:1000.Immunocytochemistry/Immunofluorescence: DNA Polymerase gamma Antibody [NBP1-33633] - analysis of methanol-fixed HeLa.

Rabbit Polyclonal
Species Human, Rat
Applications WB, ICC/IF, IHC

215-GM/CF
1 μg/lane of Recombinant Human GM-CSF was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 14 kDa.Recombinant Human GM-CSF (Catalog # 215-IL/CF) stimulates cell proliferation of the TF-1 human erythroleukemic cell line. The ED<sub>50</sub> for this effect is 6-30 pg/mL.


Species Human

181 Publications
NBP2-42388
Western Blot: LAMC2 Antibody (CL2980) [NBP2-42388] - Analysis in human cell line A-431.Immunohistochemistry-Paraffin: LAMC2 Antibody (CL2980) [NBP2-42388] - Staining of human lymph node shows absence of immunoreactivity in lymphoid tissue (negative control).

Mouse Monoclonal
Species Human
Applications WB, IHC, IHC-P

NBP1-76899
Western Blot: Neuronal Pentraxin 2 Antibody [NBP1-76899] - Mouse brain tissue lysate with NPTX2 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.Immunocytochemistry/Immunofluorescence: Neuronal Pentraxin 2 Antibody [NBP1-76899] - Immunofluorescence of NPTX2 in Human Brain cells with NPTX2 antibody at 20 ug/mL.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ELISA, ICC/IF

NBP1-49536
Western Blot: Pyruvate Carboxylase Antibody [NBP1-49536] - Analysis of Pyruvate Carboxylase in A. Human liver extracts and B. Mouse liver extractsImmunocytochemistry/Immunofluorescence: Pyruvate Carboxylase Antibody [NBP1-49536] - Immunocytochemistry of Pyruvate Carboxylase in HeLa using NBP1-49536. Nuclei (Blue) are counterstained using Hoechst 33258.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

6 Publications
NBP1-42805

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB

H00374291-P01
SDS-Page: Recombinant Human NDUFS7 Protein [H00374291-P01] - 12.5% SDS-PAGE Stained with Coomassie Blue.


Species Human

NBP1-89026
Western Blot: Ndufs4 Antibody [NBP1-89026] - Analysis in mouse cell line NIH-3T3 and rat cell line NBT-II.Immunocytochemistry/Immunofluorescence: Ndufs4 Antibody [NBP1-89026] - Immunofluorescent staining of human cell line U-2 OS shows localization to mitochondria.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

NBP1-77274
Western Blot: SCO2 Antibody [NBP1-77274] - Analysis in HL60 cell lysate lysate with antibody at (A) 1 and (B) 2 ug/mL.Immunohistochemistry-Paraffin: SCO2 Antibody [NBP1-77274] - Human liver tissue with SCO2 antibody at 2.5 ug/ml.

Rabbit Polyclonal
Species Human
Applications WB, ELISA, ICC/IF

NBP1-82432
Western Blot: Pyruvate Dehydrogenase Phosphatase/PDP1/PPM2C Antibody [NBP1-82432] - Lane 1: Marker  [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.  Lane 2: Human cell line RT-453Immunocytochemistry/Immunofluorescence: Pyruvate Dehydrogenase Phosphatase/PDP1/PPM2C Antibody [NBP1-82432] - Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm, cytosol & mitochondria.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC


Related Genes

Leigh Disease has been researched against:

Related PTMs

Leigh Disease has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Leigh Disease is also known as leigh disease, leigh syndrome, leigh's disease, mri scans, necrotizing encephalopathy infantile subacute of leigh, encephalopathy, subacute necrotizing, infantile, encephalopathy, subacute necrotizing, juvenile, infantile subacute necrotizing encephalopathy, juvenile subacute necrotizing encephalopathy, infantile necrotizing encephalomyelopathy, subacute necrotizing encephalomyelopathy, subacute necrotizing encephalopathy, leigh's necrotizing encephalopathy, leigh's disease (disorder), sne, ls.