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Leigh Disease: Disease Bioinformatics

Research of Leigh Disease has been linked to Mitochondrial Diseases, Encephalopathies, Cytochrome-c Oxidase Deficiency, Acidosis, Acidosis, Lactic. The study of Leigh Disease has been mentioned in research publications which can be found using our bioinformatics tool below. Researched pathways related to Leigh Disease include Oxidative Phosphorylation, Pathogenesis, Translation, Transport, Localization. These pathways complement our catalog of research reagents for the study of Leigh Disease including antibodies and ELISA kits against MT-ATP6, ATP5E, COX8A, CPOX, CSF2.

Leigh Disease Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Leigh Disease below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 482 products for the study of Leigh Disease that can be applied to Western Blot, Immunocytochemistry/Immunofluorescence, Flow Cytometry, Immunohistochemistry from our catalog of antibodies and ELISA kits.

NB100-56503
Western Blot: Cytochrome c Antibody (7H8.2C12) [NB100-56503] - Analysis using the Biotin conjugate of NB100-56503. Detection of Cytochrome C in 15 mgs of HeLa cell lysate using NB100-55775 at 1:1000. A 15 kDa band is detected.Immunocytochemistry/Immunofluorescence: Cytochrome c Antibody (7H8.2C12) [NB100-56503] - p73 was detected in immersion fixed Hela human cell line using Cytochrome C [7H8.2C12] Monoclonal Antibody (Catalog # NB100-56503) at 25 ug/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue). Staining was observed in the cytoplasm and mitochondria.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, Flow

47 Publications
NBP1-32550
Western Blot: COX5A Antibody [NBP1-32550] - Sample(30 ug whole cell lysate)A:HeLa S3 B:Hep G2 15% SDS PAGE, antibody diluted at 1:5000.Immunocytochemistry/Immunofluorescence: COX5A Antibody [NBP1-32550] -  A431.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ICC/IF, IHC

2 Publications
NBP2-59438
Western Blot: CPOX Antibody (36B10) [NBP2-59438] - Lane 1: Recombinant protein CPOX, Lane 2: 293T cell lysates, Lane 3: HepG2 cell lysates, Lane 4: A549 cell lysates, Lane 5: Jurkat cell lysates, Lane 6: K562 cell lysates, Lane 7: LnCaP cell lysatesImmunocytochemistry/Immunofluorescence: CPOX Antibody (36B10) [NBP2-59438] - Analysis of CPOX in Hep3B cells line, stained with DAPI (Blue) for nucleus staining and monoclonal anti-human CPOX antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green).

mouse Monoclonal
Species Human
Applications WB, ELISA, ICC/IF

NBP2-65875


Species Human

NBP2-20537
Western Blot: Surf1 Antibody [NBP2-20537] - Sample (30 ug of whole cell lysate) A: JurKat 12% SDS PAGE gel, diluted at 1:3000.

Rabbit Polyclonal
Species Human
Applications WB

NBP1-82845
Western Blot: LIAS Antibody [NBP1-82845] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells). Lane 2: NBT-II cell lysate (Rat Wistar bladder tumor cells).Immunocytochemistry/Immunofluorescence: LIAS Antibody [NBP1-82845] - Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & mitochondria. Antibody staining is shown in green.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

NBP1-32744
Western Blot: LRPPRC Antibody [NBP1-32744] - Mouse tissue extract (50 ug) was separated by 5% SDS-PAGE, and the membrane was blotted with LRP130 antibody [N3C2], Internal diluted at 1:1000.Immunocytochemistry/Immunofluorescence: LRPPRC Antibody [NBP1-32744] - HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: LRP130 protein stained by LRP130 antibody [N3C2], Internal diluted at 1:500.Blue: Hoechst 33342 staining. Scale bar = 10 um.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ICC/IF, IHC

1 Publication
NBP1-31302
Western Blot: Dihydrolipoamide Dehydrogenase/DLD Antibody [NBP1-31302] - Various whole cell extracts (30 ug) were separated by 10% SDS-PAGE, and the membrane was blotted with DLD antibody diluted at 1:1000.Immunocytochemistry/Immunofluorescence: Dihydrolipoamide Dehydrogenase/DLD Antibody [NBP1-31302] - HeLa cells were fixed in ice-cold MeOH for 5 min. Green: DLD protein stained by DLD antibody diluted at 1:500. Blue: Hoechst 33342 staining.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

     1 Review

NBP1-33633
Western Blot: DNA Polymerase gamma Antibody [NBP1-33633] - Various whole cell extracts (30 ug) were separated by 5% SDS-PAGE, and the membrane was blotted with DNA polymerase gamma antibody  diluted by 1:1000.Immunocytochemistry/Immunofluorescence: DNA Polymerase gamma Antibody [NBP1-33633] - analysis of methanol-fixed HeLa.

Rabbit Polyclonal
Species Human, Rat
Applications WB, ICC/IF, IHC

7954-GM/CF


Species Human

1 Publication
NBP2-42388
Western Blot: LAMC2 Antibody (CL2980) [NBP2-42388] - Analysis in A-431 cells transfected with control siRNA, target specific siRNA probe #1 and #2, using Anti-LAMC2 antibody. Remaining relative intensity is presented. Loading control: Anti-GAPDH.Immunohistochemistry-Paraffin: LAMC2 Antibody (CL2980) [NBP2-42388] - Staining in human fallopian tube and liver tissues. Corresponding LAMC2 RNA-seq data are presented for the same tissues.

Mouse Monoclonal
Species Human
Applications WB, IHC, IHC-P

NBP1-76899
Western Blot: Neuronal Pentraxin 2 Antibody [NBP1-76899] - Mouse brain tissue lysate with NPTX2 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.Immunohistochemistry-Paraffin: Neuronal Pentraxin 2 Antibody [NBP1-76899] - Staining of NPTX2 in mouse brain tissue with NPTX2 antibody at 5 ug/ml.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ELISA, IHC

NBP1-49536
Western Blot: Pyruvate Carboxylase Antibody [NBP1-49536] - Analysis of Pyruvate Carboxylase in A. Human liver extracts and B. Mouse liver extractsImmunocytochemistry/Immunofluorescence: Pyruvate Carboxylase Antibody [NBP1-49536] - Immunocytochemistry of Pyruvate Carboxylase in HeLa using NBP1-49536. Nuclei (Blue) are counterstained using Hoechst 33258.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications ICC/IF, IHC, IHC-P

7 Publications
NBP1-42813

Rabbit Polyclonal
Species Drosophila, Human (Negative)
Applications WB, ICC/IF

H00374291-P01
SDS-Page: Recombinant Human NDUFS7 Protein [H00374291-P01] - 12.5% SDS-PAGE Stained with Coomassie Blue.


Species Human

NBP1-89026
Western Blot: Ndufs4 Antibody [NBP1-89026] - Analysis in HEK293 cells transfected with control siRNA, target specific siRNA probe #1 and #2. Remaining relative intensity is presented. Loading control: Anti-GAPDH.Immunocytochemistry/Immunofluorescence: Ndufs4 Antibody [NBP1-89026] - Immunofluorescent staining of human cell line U-2 OS shows localization to mitochondria.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

NBP1-77274
Western Blot: SCO2 Antibody [NBP1-77274] - Analysis in HL60 cell lysate lysate with antibody at (A) 1 and (B) 2 ug/mL.Immunohistochemistry-Paraffin: SCO2 Antibody [NBP1-77274] - Human liver tissue with SCO2 antibody at 2.5 ug/ml.

Rabbit Polyclonal
Species Human
Applications WB, ELISA, IHC

NBP1-87308
Western Blot: Pyruvate Dehydrogenase Phosphatase/PDP1/PPM2C Antibody [NBP1-87308] - Analysis in human cell lines SK-MEL-30 and MCF-7. Corresponding RNA-seq data are presented for the same cell lines. Loading control: Anti-PFN1.Immunohistochemistry-Paraffin: Pyruvate Dehydrogenase Phosphatase/PDP1/PPM2C Antibody [NBP1-87308] - Staining of human cerebral cortex shows moderate cytoplasmic positivity in neuronal cells.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC, IHC-P


Related Genes

Leigh Disease has been researched against:

Related PTMs

Leigh Disease has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Leigh Disease is also known as leigh disease, leigh syndrome, leigh's disease, mri scans, necrotizing encephalopathy infantile subacute of leigh, encephalopathy, subacute necrotizing, infantile, encephalopathy, subacute necrotizing, juvenile, infantile subacute necrotizing encephalopathy, juvenile subacute necrotizing encephalopathy, infantile necrotizing encephalomyelopathy, subacute necrotizing encephalomyelopathy, subacute necrotizing encephalopathy, leigh's necrotizing encephalopathy, leigh's disease (disorder), sne, ls.