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Leber Congenital Amaurosis: Disease Bioinformatics

Research of Leber Congenital Amaurosis has been linked to Amaurosis, Blind Vision, Retinitis Pigmentosa, Retinal Degeneration, Retinal Diseases. The study of Leber Congenital Amaurosis has been mentioned in research publications which can be found using our bioinformatics tool below. Researched pathways related to Leber Congenital Amaurosis include Localization, Pathogenesis, Phototransduction, Transport, Cell Death. These pathways complement our catalog of research reagents for the study of Leber Congenital Amaurosis including antibodies and ELISA kits against RPE65, GUCY2D, CLTA, PTPRC, RETINAL DYSTROPHY.

Leber Congenital Amaurosis Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Leber Congenital Amaurosis below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 1832 products for the study of Leber Congenital Amaurosis that can be applied to Western Blot, Chromatin Immunoprecipitation, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence from our catalog of antibodies and ELISA kits.

NB100-355
Immunohistochemistry-Frozen: RPE65 Antibody (401.8B11.3D9) [NB100-355] - Staining of RPE65 in a cryosection of mouse retina tissue using RPE65 antibody (clone 401.8B11.3D9).Western Blot: RPE65 Antibody (401.8B11.3D9) [NB100-355] - WB analysis of RPE65 in 20ug lysate of COS7 cells expressing recombinant Human RPE65 (Lane 1) and 5ug of Bovine retinal pigment epithelium membrane fraction (Lane 2). Blot processed for detection with alkaline phosphatase conjugated goat-anti Mouse IgG secondary antibody and NBT/BCIP substrate.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, Flow, ICC/IF

     7 Reviews

66 Publications
H00003000-M06
Immunocytochemistry/Immunofluorescence: GUCY2D Antibody (1E6) [H00003000-M06] - Analysis of monoclonal antibody to GUCY2D on HeLa cell. Antibody concentration 10 ug/mlELISA: GUCY2D Antibody (1E6) [H00003000-M06] - Detection limit for recombinant GST tagged GUCY2D is approximately 3ng/ml as a capture antibody.

Mouse Monoclonal
Species Human
Applications WB, ELISA, ICC/IF

NBP2-53232
Immunohistochemistry-Paraffin: Clathrin light chain Antibody (SPM174) [NBP2-53232] - Formalin-fixed, paraffin-embedded Human Pancreas stained with Clathrin, LC Monoclonal Antibody (SPM174).

Mouse Monoclonal
Species Human
Applications WB, Flow, ICC/IF

NB100-77417
Immunohistochemistry-Paraffin: CD45 Antibody (30-F11) [NB100-77417] - Analysis of FFPE section of mouse spleen using rat monoclonal CD45 antibody (clone 30-F11) at 1:50 dilution. The antibody generated an expected membrane staining in the red and white pulp spleenocytes of the tested spleen section.Immunohistochemistry-Frozen: CD45 Antibody (30-F11) [NB100-77417] - Analysis of a mouse spleen cryosection using CD45 antibody clone 30-F11 at 1:50 dilution. The signal was detected using goat anti-rat Alexa fluor 488 secondary with DAPI counterstaining. Image submitted via a verified customer review.

Rat Monoclonal
Species Human, Mouse
Applications WB, Flow, Func

     4 Reviews

24 Publications
NBP2-56113
Western Blot: CRB1 Antibody [NBP2-56113] - Analysis in human cell line RT-4, human cell line U-251 MG and human plasma.Immunohistochemistry-Paraffin: CRB1 Antibody [NBP2-56113] - Staining of human retina shows cytoplasmic positivity in all layers of retina.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

NBP2-01327
Western Blot: AIPL1 Antibody (3B4) [NBP2-01327] Analysis of extracts (35ug) from 9 different cell lines by using anti-AIPL1 monoclonal antibody.Immunocytochemistry/Immunofluorescence: AIPL1 Antibody (3B4) [NBP2-01327] - Staining of COS7 cells transiently transfected by pCMV6-ENTRY AIPL1.

Mouse Monoclonal
Species Human
Applications WB, Flow, ICC/IF

NBP2-13249
Immunohistochemistry-Paraffin: RPGRIP1 Antibody [NBP2-13249] - Staining in human testis and pancreas tissues using anti-RPGRIP1 antibody. Corresponding RPGRIP1 RNA-seq data are presented for the same tissues.Immunohistochemistry-Paraffin: RPGRIP1 Antibody [NBP2-13249] - Staining of human pancreas shows low expression as expected.

Rabbit Polyclonal
Species Human
Applications IHC, IHC-P

H00001406-M02
Western Blot: CRX/CORD2 Antibody (4G11) [H00001406-M02] - Analysis of CRX expression in transfected 293T cell line by CRX monoclonal antibody (M02), clone 4G11.Lane 1: CRX transfected lysate(32 KDa).Lane 2: Non-transfected lysate.Immunocytochemistry/Immunofluorescence: CRX/CORD2 Antibody (4G11) [H00001406-M02] - Retinal development is recapitulated in differentiating stem cells. Immunostaining of day 49 cultures shows remnants of retinal organization. CRX+ photoreceptor progenitors in green and mCherry+ RGCs in magenta. CRX+ cells - white arrows - appear to segregate from mCherry+ axons, suggesting division between the outer nuclear layer and the nerve fiber layer. Scale bar?=?500?um.   Image collected and cropped by CiteAb from the following publication (http://www.nature.com/articles/srep16595), licensed under a CC-BY licence.

Mouse Monoclonal
Species Human, Mouse, Bovine
Applications WB, ChIP, ELISA

19 Publications
NBP2-60655
Western Blot: ERG Antibody [NBP2-60655] - Total protein from Human THP-1, Jurkat and K562 cells was separated on a 7.5% gel by SDS-PAGE, transferred to PVDF membrane and blocked in 5% non-fat milk in TBST. The membrane was probed with 2.0 ug/ml anti-ERG in blocking buffer and detected with an anti-rabbit HRP secondary antibody using chemiluminescence.Immunocytochemistry/Immunofluorescence: ERG Antibody [NBP2-60655] - HeLa cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.5% Triton-X100. The cells were incubated with anti-ERG at 5 ug/ml overnight at 4C and detected with an anti-rabbit Dylight 488 (Green) at a 1:500 dilution. Alpha tubulin (DM1A) NB100-690 was used as a co-stain at a 1:1000 dilution and detected with an anti-mouse Dylight 550 (Red) at a 1:500 dilution. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 40X objective.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

NBP3-03109
Western Blot: Kv11.1 Antibody [NBP3-03109] - Analysis of extracts of various cell lines, using Kv11.1 antibody at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL EnhanImmunohistochemistry-Paraffin: Kv11.1 Antibody [NBP3-03109] - Paraffin-embedded human lung cancer using Kv11.1 antibody at dilution of 1:100 (40x lens).

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC, IHC-P

NB100-86991
Western Blot: CEP290 Antibody [NB100-86991] - Detection of human CEP290 by western blot and immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded) and HEK293T (T; 50 ug) cells. Antibodies: Affinity purified rabbit anti-CEP290 antibody NB100-86991 used for WB at 0.1 ug/ml (A) and 1 ug/ml (B) and used for IP at 3 ug/mg lysate. Detection: Chemiluminescence with exposure times of 30 seconds (A) and 10 second (B).Immunocytochemistry/Immunofluorescence: CEP290 Antibody [NB100-86991] - NBF-fixed asynchronous HeLa cells. Antibody used at a dilution of 1:500.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ICC/IF, IP

9 Publications
H00145226-D01P
Western Blot: RDH12 Antibody [H00145226-D01P] - Analysis of RDH12 expression in transfected 293T cell line by RDH12 polyclonal antibody.Lane 1: RDH12 transfected lysate(35.10 KDa).Lane 2: Non-transfected lysate.

Rabbit Polyclonal
Species Human
Applications WB

NBP1-47602
Western Blot: Rhodopsin Antibody (1D4) [NBP1-47602] - Analysis of Human Cell lysates showing detection of Rhodopsin protein using Mouse Anti-Rhodopsin Monoclonal Antibody, Clone 1D4. Load: 15 ug protein. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Rhodopsin Monoclonal Antibody at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT.Immunocytochemistry/Immunofluorescence: Rhodopsin Antibody (1D4) [NBP1-47602] - Analysis using Mouse Anti-Rhodopsin Monoclonal Antibody, Clone 1D4. Tissue: backskin. Species: Mouse. Fixation: Bouins Fixative and paraffin-embedded. Primary Antibody: Mouse Anti-Rhodopsin Monoclonal Antibody at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Dull epidermal staining.

Mouse Monoclonal
Species Human, Mouse, Bovine
Applications WB, ELISA, ICC/IF

3 Publications
NBP1-84412
Immunohistochemistry-Paraffin: RPGR Antibody [NBP1-84412] - Staining of human liver shows moderate to strong cytoplasmic positivity in hepatocytes.Immunohistochemistry-Paraffin: RPGR Antibody [NBP1-84412] - Staining of human testis shows moderate cytoplasmic positivity in cells in seminiferous ducts.

Rabbit Polyclonal
Species Human
Applications IHC, IHC-P

2 Publications
NBP1-56853
Western Blot: RPE Antibody [NBP1-56853] - Human Muscle lysate, concentration 0.2-1 ug/ml.Immunocytochemistry/Immunofluorescence: RPE Antibody [NBP1-56853] - Antibody  0 Formalin Fixed Paraffin Embedded Tissue: Human Adult Liver  Observed Staining: Cytoplasm but only in connective tissue cells in the interlobular septum, very low tissue distribution Primary Antibody

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

NBP2-48587
Immunohistochemistry-Paraffin: Lebercilin Antibody [NBP2-48587] - Staining of human fallopian tube shows strong positivity in cilia.

Rabbit Polyclonal
Species Human
Applications IHC, IHC-P

NBP2-50444
Western Blot: LRAT Antibody (M34-P1F10) [NBP2-50444] - Shows detection of LRAT in an overexpression lysate.Immunocytochemistry/Immunofluorescence: LRAT Antibody (M34-P1F10) [NBP2-50444]

Mouse Monoclonal
Species Human
Applications WB, ELISA, ICC/IF

NBP2-55158
Immunohistochemistry-Paraffin: GCAP1 Antibody [NBP2-55158] - Staining of human liver shows no positivity in hepatocytes as expected.Immunohistochemistry-Paraffin: GCAP1 Antibody [NBP2-55158] - Staining of human duodenum shows no positivity in glandular cells as expected.

Rabbit Polyclonal
Species Human
Applications IHC, IHC-P


Related Genes

Leber Congenital Amaurosis has been researched against:

Related PTMs

Leber Congenital Amaurosis has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Leber Congenital Amaurosis is also known as leber congenital amaurosis, lca, leber's congenital tapetoretinal degeneration, leber's congenital tapetoretinal dysplasia, hereditary epithelial dysplasia of retina, congenital absence of the rods and cones, congenital amaurosis of retinal origin, dysgenesis neuroepithelialis retinae, amaurosis congenita of leber, type 1, heredoretinopathia congenitalis, amaurosis congenita of leber i, leber's amaurosis (disorder), amaurosis congenita of leber, amaurosis, leber congenital, lebers congenital amaurosis, hereditary retinal aplasia, intraepithelial neoplasia, neonatal hemochromatosis, retinal aplasia, leber's disease, amaurosis, crb.