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Leber Congenital Amaurosis: Disease Bioinformatics

Research of Leber Congenital Amaurosis has been linked to Amaurosis, Blind Vision, Retinitis Pigmentosa, Retinal Degeneration, Retinal Diseases. The study of Leber Congenital Amaurosis has been mentioned in research publications which can be found using our bioinformatics tool below. Researched pathways related to Leber Congenital Amaurosis include Localization, Pathogenesis, Phototransduction, Transport, Cell Death. These pathways complement our catalog of research reagents for the study of Leber Congenital Amaurosis including antibodies and ELISA kits against RETINAL DYSTROPHY, RP, CLTA, CRX, ERG.

Leber Congenital Amaurosis Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Leber Congenital Amaurosis below! For more information on how to use Laverne, please read the How to Guide.
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Top Research Reagents

We have 1371 products for the study of Leber Congenital Amaurosis that can be applied to Chromatin Immunoprecipitation, Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.

NB100-355
Immunohistochemistry-Frozen: RPE65 Antibody (401.8B11.3D9) [NB100-355] - Staining of RPE65 in a cryosection of mouse retina tissue using RPE65 antibody (clone 401.8B11.3D9).Western Blot: RPE65 Antibody (401.8B11.3D9) [NB100-355] - WB analysis of RPE65 in 20ug lysate of COS7 cells expressing recombinant Human RPE65 (Lane 1) and 5ug of Bovine retinal pigment epithelium membrane fraction (Lane 2). Blot processed for detection with alkaline phosphatase conjugated goat-anti Mouse IgG secondary antibody and NBT/BCIP substrate.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, Flow, ICC/IF

     6 Reviews

45 Publications
H00003000-M06
Immunocytochemistry/Immunofluorescence: GUCY2D Antibody (1E6) [H00003000-M06] - Analysis of monoclonal antibody to GUCY2D on HeLa cell. Antibody concentration 10 ug/mlELISA: GUCY2D Antibody (1E6) [H00003000-M06] - Detection limit for recombinant GST tagged GUCY2D is approximately 3ng/ml as a capture antibody.

Mouse Monoclonal
Species Human
Applications WB, ELISA, ICC/IF

NBP2-38638
Western Blot: Clathrin light chain Antibody [NBP2-38638] - Lane 1: Marker  [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.  Lane 2: Human cell line RT-4.  Lane 3: Human cell line U-251MG.  Lane 4: Human Plasma.  Lane 5: Human liver tissue.  Lane 6: Human tonsil tissueImmunohistochemistry-Paraffin: Clathrin light chain Antibody [NBP2-38638] - Staining in human placenta and pancreas tissues using anti-CLTA antibody. Corresponding CLTA RNA-seq data are presented for the same tissues.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

NB100-77417
Immunohistochemistry-Paraffin: CD45 Antibody (30-F11) [NB100-77417] - Analysis of FFPE section of mouse spleen using rat monoclonal CD45 antibody (clone 30-F11) at 1:50 dilution. The antibody generated an expected membrane staining in the red and white pulp spleenocytes of the tested spleen section.Immunohistochemistry-Frozen: CD45 Antibody (30-F11) [NB100-77417] - Analysis of a mouse spleen cryosection using CD45 antibody clone 30-F11 at 1:50 dilution. The signal was detected using goat anti-rat Alexa fluor 488 secondary with DAPI counterstaining. Image submitted via a verified customer review.

Rat Monoclonal
Species Mouse
Applications WB, Flow, ICC/IF

     4 Reviews

18 Publications
NBP2-56113
Western Blot: CRB1 Antibody [NBP2-56113] - Analysis in human cell line RT-4, human cell line U-251 MG and human plasma.Immunohistochemistry-Paraffin: CRB1 Antibody [NBP2-56113] - Staining of human retina shows cytoplasmic positivity in all layers of retina.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

NBP2-01327
Western Blot: AIPL1 Antibody (3B4) [NBP2-01327] Analysis of extracts (35ug) from 9 different cell lines by using anti-AIPL1 monoclonal antibody.Immunocytochemistry/Immunofluorescence: AIPL1 Antibody (3B4) [NBP2-01327] - Staining of COS7 cells transiently transfected by pCMV6-ENTRY AIPL1.

Mouse Monoclonal
Species Human
Applications WB, Flow, ICC/IF

NBP2-13249
Immunohistochemistry-Paraffin: RPGRIP1 Antibody [NBP2-13249] - Staining of human testis shows high expression.Immunohistochemistry-Paraffin: RPGRIP1 Antibody [NBP2-13249] - Staining of human pancreas shows low expression as expected.

Rabbit Polyclonal
Species Human
Applications ICC/IF, IHC, IHC-P

H00001406-M02
Western Blot: CRX/CORD2 Antibody (4G11) [H00001406-M02] - CRX monoclonal antibody (M02), clone 4G11 Analysis of CRX expression in IMR-32.Western Blot: CRX/CORD2 Antibody (4G11) [H00001406-M02] - Analysis of CRX expression in transfected 293T cell line by CRX monoclonal antibody (M02), clone 4G11.Lane 1: CRX transfected lysate(32 KDa).Lane 2: Non-transfected lysate.

Mouse Monoclonal
Species Human, Mouse
Applications WB, ChIP, ELISA

15 Publications
NBP2-60655
Western Blot: ERG Antibody [NBP2-60655] - Total protein from Human THP-1, Jurkat and K562 cells was separated on a 7.5% gel by SDS-PAGE, transferred to PVDF membrane and blocked in 5% non-fat milk in TBST. The membrane was probed with 2.0 ug/ml anti-ERG in blocking buffer and detected with an anti-rabbit HRP secondary antibody using chemiluminescence.Immunocytochemistry/Immunofluorescence: ERG Antibody [NBP2-60655] - HeLa cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.5% Triton-X100. The cells were incubated with anti-ERG at 5 ug/ml overnight at 4C and detected with an anti-rabbit Dylight 488 (Green) at a 1:500 dilution. Alpha tubulin (DM1A) NB100-690 was used as a co-stain at a 1:1000 dilution and detected with an anti-mouse Dylight 550 (Red) at a 1:500 dilution. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 40X objective.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

H00003757-Q01
12.5% SDS-PAGE Stained with Coomassie Blue.


Species Human

NB100-86991
Western Blot: CEP290 Antibody [NB100-86991] - Whole cell lysate from HeLa (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded) and 293T (T; 50 mcg) cells. NB100-86991 used for WB at 0.1 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate.Immunocytochemistry/Immunofluorescence: CEP290 Antibody [NB100-86991] - NBF-fixed asynchronous HeLa cells. Antibody used at a dilution of 1:500.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ICC/IF, IP

8 Publications
H00145226-M01
Immunocytochemistry/Immunofluorescence: RDH12 Antibody (1E11) [H00145226-M01] - Analysis of monoclonal antibody to RDH12 on HeLa cell. Antibody concentration 10 ug/ml.Sandwich ELISA: RDH12 Antibody (1E11) [H00145226-M01] - Detection limit for recombinant GST tagged RDH12 is 0.3 ng/ml as a capture antibody.

Mouse Monoclonal
Species Human
Applications WB, ELISA, ICC/IF

NBP2-25159
Western Blot: Rhodopsin Antibody (A531) [NBP2-25159] - Blot of bovine retinal extracts. The antibody stains a band corresponing to retinal Rhodopsin at about 35kDa. Bands about 70 kDa and 140 kDa are aggregated forms of Rhodopsin. Note, due to the highly hydrophobic nature of Rhodopsin, it is important not to boil a sample containing it in SDS-PAGE sample buffer, as this will result in more extensive aggregation of the Rhodopsin protein.Immunocytochemistry/Immunofluorescence: Rhodopsin Antibody (A531) [NBP2-25159] - Pig retinal section stained with NBP2-25159 (green) and counterstained with rabbit polyclonal antibody to NF-M NB300-133 (red) and DNA (blue). Rhodopsin is most abundant in the outer segments of retina (OS), NF-M is abundant in the optic nerve fiber layer (ONFL), but seen in processes and neurons in other regions also. Other layers are pigmented epithelium (PE), outer and inner nuclear layers (ONL, INL), outer and inner plexiform layers (OPL, IPL) and ganglion cell layer (GCL).

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

1 Publication
NBP1-84412
Western Blot: RPGR Antibody [NBP1-84412] - Analysis in human cell line RT-4 and human cell line EFO-21.Immunohistochemistry-Paraffin: RPGR Antibody [NBP1-84412] - Staining of human fallopian tube shows moderate to strong cytoplasmic positivity in glandular cells.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

2 Publications
NBP1-56853
Western Blot: RPE Antibody [NBP1-56853] - Human Muscle lysate, concentration 0.2-1 ug/ml.Immunocytochemistry/Immunofluorescence: RPE Antibody [NBP1-56853] - Antibody  0 Formalin Fixed Paraffin Embedded Tissue: Human Adult Liver  Observed Staining: Cytoplasm but only in connective tissue cells in the interlobular septum, very low tissue distribution Primary Antibody

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

NBP1-86759
Western Blot: Lebercilin Antibody [NBP1-86759] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells) Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells)Immunohistochemistry-Paraffin: Lebercilin Antibody [NBP1-86759] - Staining of human fallopian tube shows moderate positivity in cilia of glandular cells.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC, IHC-P

NBP2-50444
Western Blot: LRAT Antibody (M34-P1F10) [NBP2-50444] - Shows detection of LRAT in an overexpression lysate.Immunocytochemistry/Immunofluorescence: LRAT Antibody (M34-P1F10) [NBP2-50444]

Mouse Monoclonal
Species Human
Applications WB, ELISA, ICC/IF

NBP2-55158
Immunohistochemistry-Paraffin: GCAP1 Antibody [NBP2-55158] - Staining of human retina shows strong cytoplasmic positivity in photoreceptor layer and outer plexiform layer.

Rabbit Polyclonal
Species Human
Applications IHC, IHC-P


Related Genes

Leber Congenital Amaurosis has been researched against:

Related PTMs

Leber Congenital Amaurosis has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Leber Congenital Amaurosis is also known as leber congenital amaurosis, lca, leber's congenital tapetoretinal degeneration, leber's congenital tapetoretinal dysplasia, hereditary epithelial dysplasia of retina, congenital absence of the rods and cones, congenital amaurosis of retinal origin, dysgenesis neuroepithelialis retinae, amaurosis congenita of leber, type 1, heredoretinopathia congenitalis, amaurosis congenita of leber i, leber's amaurosis (disorder), amaurosis congenita of leber, amaurosis, leber congenital, lebers congenital amaurosis, hereditary retinal aplasia, intraepithelial neoplasia, neonatal hemochromatosis, retinal aplasia, leber's disease, amaurosis, crb.