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Langer-giedion Syndrome: Disease Bioinformatics

Langer-Giedion syndrome, also known as Trichorhinophalangeal Syndrome Type II, is a genetic condition that causes bone abnormalities and distinctive facial features. The cause of Langer Giedion syndrome is having multiple benign bone tumors called extoses which results in limited range of joint movement, and pressure on the nerves, blood vessels, the spinal cord, and the tissues surrounding the extoses. Appearance wise affected individuals have short stature, sparse scalp hair, a rounded nose, a long flat area between the nose and the upper lip, and a thin upper lip. People with Langer Giedion syndrome may also have some intellectual disabilities. Langer Giedion syndrome is extremely rare and has no cure or treatment.

Langer-giedion Syndrome Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Langer-giedion Syndrome below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 958 products for the study of Langer-giedion Syndrome that can be applied to Western Blot, Chromatin Immunoprecipitation, Immunocytochemistry/Immunofluorescence, Flow Cytometry, Immunohistochemistry, Chromatin Immunoprecipitation (ChIP) from our catalog of antibodies and ELISA kits.

NBP1-91875
Immunohistochemistry-Paraffin: Exostosin 1 Antibody [NBP1-91875] - Staining of human prostate shows moderate cytoplasmic positivity in smooth muscle cells.Immunohistochemistry-Paraffin: Exostosin 1 Antibody [NBP1-91875] - Staining of human rectum shows strong membranous and cytoplasmic positivity in glandular cells.

Rabbit Polyclonal
Species Human, Mouse
Applications IHC, IHC-P

1 Publication
AF4838
Western blot shows lysates of MDA‑MB‑453 human breast cancer cell line and MCF‑7 human breast cancer cell line. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human TRPS1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4838) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <A class=NoLineLink href=Simple Western lane view shows lysates of MCF‑7 human breast cancer cell line, loaded at 0.2 mg/mL. A specific band was detected for TRPS1 at approximately 191 kDa (as indicated) using 10 µg/mL of Goat Anti-Human TRPS1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4838) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <A class=NoLineLink href=

Goat Polyclonal
Species Human
Applications WB, Simple Western

4 Publications
NBP1-31133
Western Blot: TBP like protein TLP Antibody [NBP1-31133] - Sample (30 ug of whole cell lysate) A: 293T 12% SDS PAGE, antibody diluted at 1:2000.Immunocytochemistry/Immunofluorescence: TBP like protein TLP Antibody [NBP1-31133] - NT2D1 cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: TLP protein stained by TLP antibody diluted at 1:500. Blue: Hoechst 33342 staining. Scale bar = 10 um.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ICC/IF, IHC

NBP2-32906
Flow (Intracellular): TYRP1 Antibody (TA99) [NBP2-32906] - Flow Cytometry: TYRP1 Antibody (TA99) - Azide and BSA Free [NBP2-34720] - An intracellular stain was performed on SK-MEL-28 cells with TYRP1 Antibody (TA99) NBP2-34720PE (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 2.5 ug/mL for 30 minutes at room temperature. Both antibodies were conjugated to phycoerythrin. Image using the Azide and BSA Free form of this antibody.Flow Cytometry: TYRP1 Antibody (TA99) [NBP2-32906] - Flow Cytometry: TYRP1 Antibody (TA99) [Allophycocyanin] [NBP2-34720APC] - An intracellular stain was performed on SK-MEL-28 cells with TYRP1 Antibody (TA99) NBP2-34720APC (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 1 ug/mL for 30 minutes at room temperature. Both antibodies were conjugated to allophycocyanin. Image using the Allophycocyanin form of this antibody.

Mouse Monoclonal
Species Human, Mouse
Applications WB, Flow, ICC/IF

2 Publications
NBP2-30472
Immunocytochemistry/Immunofluorescence: Bcl-9 Antibody [NBP2-30472] - Staining of human cell line SH-SY5Y shows localization to nucleoplasm & nuclear bodies. Antibody staining is shown in green.Immunohistochemistry-Paraffin: Bcl-9 Antibody [NBP2-30472] - Staining of human testis shows moderate nuclear positivity in cells in seminiferous ducts.

Rabbit Polyclonal
Species Human
Applications ICC/IF, IHC, IHC-P

NB110-60011
Western Blot: WT1 Antibody (6F-H2) [NB110-60011] - Whole cell protein from human K562, HEK293 and kidney tissue was separated on a 12% gel by SDS-PAGE, transferred to PVDF membrane and blocked in 5% non-fat milk in TBST. The membrane was probed with 2.0 ug/ml anti-WT1 in block buffer and detected with an anti-mouse HRP secondary antibody using chemiluminescence.Immunohistochemistry-Paraffin: WT1 Antibody (6F-H2) [NB110-60011] - Staining of human kidney glomerulus tissue. Heat mediated antigen retrieval was performed by heating in citrate buffer (pH 6) at 95C for 20 minutes. Image from verified customer review.

Mouse Monoclonal
Species Human, Mouse
Applications WB, Simple Western, ICC/IF

     3 Reviews

6 Publications
H00027130-P02
12.5% SDS-PAGE Stained with Coomassie Blue.


Species Human

NBP1-92025
Western Blot: Invadolysin Antibody [NBP1-92025] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells). Lane 2: NBT-II cell lysate (Rat Wistar bladder tumor cells).Immunocytochemistry/Immunofluorescence: Invadolysin Antibody [NBP1-92025] - Immunofluorescent staining of human cell line A-431 shows localization to cytosol & focal adhesion sites. Antibody staining is shown in green.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

NB600-302
Western Blot: c-Myc Antibody (9E10) [NB600-302] - Analysis of c-myc in Jurkat cell lysates using NB600-302.Immunohistochemistry-Paraffin: c-Myc Antibody (9E10) [NB600-302] - c-Myc was detected in immersion fixed paraffin-embedded sections of human breast cancer using anti-human mouse monoclonal antibody (Catalog # NB600-302, clone 9E10) at 1:50 dilution overnight at 4 C. Tissue was stained using the VisuCyte anti-mouse HRP polymer detection reagent (Catalog # VC001) with DAB chromogen (brown) and counterstained with hematoxylin (blue). <br/>Images may not be copied, printed or otherwise disseminated without express written permission of Novus Biologicals a bio-techne brand.

Mouse Monoclonal
Species Human, Mouse, Drosophila
Applications WB, Simple Western, ChIP

     4 Reviews

30 Publications
NBP1-82805
Western Blot: MRPL28 Antibody [NBP1-82805] - Analysis using Anti-MRPL28 antibody NBP1-82805 (A) shows similar pattern to independent antibody NBP2-38760 (B).Immunocytochemistry/Immunofluorescence: MRPL28 Antibody [NBP1-82805] - Immunofluorescent staining of human cell line U-2 OS shows localization to mitochondria.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

AF1927
    Western  blot shows 25 ng of Recombinant Human BMP‑1/<br>PCP  (Catalog # <a class=        Western  blot shows 25 ng of Recombinant Human BMP‑1/<br>PCP  (Catalog # <a class=

Goat Polyclonal
Species Human
Applications WB, IP, ICC

5 Publications
NBP1-58297
Western Blot: Ext2 Antibody [NBP1-58297] - Human Hela, Antibody Dilution: 1.0 ug/ml EXT2 is supported by BioGPS gene expression data to be expressed in HeLa.Immunohistochemistry: Ext2 Antibody [NBP1-58297] - Formalin Fixed Paraffin Embedded Tissue: Human heart Tissue Observed Staining: Cytoplasmic Primary Antibody Concentration: N/A Other Working Concentrations: 1:600 Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec

Rabbit Polyclonal
Species Human
Applications WB, IHC

NB300-750
Western Blot: Pax6 Antibody [NB300-750] - Analysis of sheep retinal extractImmunocytochemistry/Immunofluorescence: Pax6 Antibody [NB300-750] - ARPE-19 monolayer on glass substrate. Fixative Methanol Blocking Goat Serum. Dilution 1:100. Incubation 1h @ RT. This image was submitted via customer Review.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

     4 Reviews

4 Publications
H00029107-M08
Western Blot: NXT1 Antibody (4F11) [H00029107-M08] - Analysis of NXT1 expression in transfected 293T cell line by NXT1 monoclonal antibody (M08), clone 4F11. Lane 1: NXT1 transfected lysatE (15.51 KDa). Lane 2: Non-transfected lysate.Immunocytochemistry/Immunofluorescence: NXT1 Antibody (4F11) [H00029107-M08] - Analysis of monoclonal antibody to NXT1 on HeLa cell. Antibody concentration 10 ug/ml

Mouse Monoclonal
Species Human
Applications WB, ELISA, ICC/IF

MAB6798
Western blot shows lysates of 293T human embryonic kidney cell line and HeLa human cervical epithelial carcinoma cell line. PVDF Membrane was probed with 1 µg/mL of Mouse Anti-Human p15INK4b/CDKN2B Monoclonal Antibody (Catalog # MAB6798) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # <A class=NoLineLink href=    p15INK4b/CDKN2B  was detected in immersion fixed HeLa human cervical epithelial carcinoma cell  line using Mouse Anti-Human p15INK4b/CDKN2B Monoclonal Antibody (Catalog #  MAB6798) at 3 µg/mL for 3 hours at room temperature.  Cells were stained using the NorthernLights™ 557-conjugated  Anti-Mouse IgG Secondary Antibody (red; Catalog # <a class=

Mouse Monoclonal
Species Human
Applications WB, ICC

NBP1-82454
Western Blot: SUB1 Antibody [NBP1-82454] - Analysis in human cell line RPMI-8226.Immunocytochemistry/Immunofluorescence: SUB1 Antibody [NBP1-82454] - Staining of human cell line U-2 OS shows localization to nucleus & nucleoli. Antibody staining is shown in green.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ICC/IF, IHC

2 Publications
NBP1-84870
Western Blot: EIF3S3 Antibody [NBP1-84870] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells). Lane 2: NBT-II cell lysate (Rat Wistar bladder tumor cells).Immunocytochemistry/Immunofluorescence: EIF3S3 Antibody [NBP1-84870] - Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

MAB97203
    Myoglobin  was detected in immersion fixed paraffin-embedded sections of human heart  using Rabbit Anti-Human Myoglobin Monoclonal Antibody (Catalog # MAB97203) at  3 µg/mL for 1 hour at room temperature followed by  incubation with the Anti-Rabbit IgG VisUCyte™ HRP Polymer Antibody  (Catalog # <a class=    Western  blot shows lysates of human heart tissue, mouse heart tissue, rat heart  tissue, and human liver tissue. PVDF membrane was probed with  0.5 µg/mL of Rabbit Anti-Human Myoglobin Monoclonal Antibody  (Catalog # MAB97203) followed by HRP-conjugated Anti-Rabbit IgG Secondary  Antibody (Catalog # <a class=

Rabbit Monoclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, ELISA

H00057804-M01A
ELISA: POLD4 Antibody (2B11) [H00057804-M01A] - Detection limit for recombinant GST tagged POLD4 is approximately 0.3ng/ml as a capture antibody.

Mouse Monoclonal
Species Human
Applications WB, ELISA

5 Publications

Related Genes

Langer-giedion Syndrome has been researched against:

Alternate Names

Langer-giedion Syndrome is also known as Giedion-langer Syndrome, Langer Giedion Syndrome, Syndrome, Langer-giedion, Trichorhinophalangeal Syndrome Type Ii, Trichorhinophalangeal Syndrome With Exostoses.