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Infantile Severe Myoclonic Epilepsy: Disease Bioinformatics

Epilepsy is defined as a diverse set of neurological disorders characterized by seizures. These seizures occur due to abnormal electrical activity in the brain. Factors that may lead to epilepsy include, but are not limited to, brain trauma, gene mutations, strokes, brain cancer, and extensive drug and alcohol use. Seizures occur due to a large release of glutamate, which causes a spread of excitation throughout the brain, which propagates the electrical signal and can lead to neuronal death. Myoclonic infantile epilepsy is characterized by seizures that contain rapid, jerk-like movements that can affect the face and limbs. Myoclonic seizures occur during wakefulness. In infants, myoclonic seizures can be caused by include brain malformations, inborn errors of metabolism, and neurogenetic disorders. The severity of the seizures can vary, and the severe episodes can lead to the child falling and undergoing violent convulsions. About 50 million people have epilepsy, with 80% of that population located in developing countries. It is possible to control epilepsy with medicine, but many cases may require surgery in order to relieve symptoms.

Infantile Severe Myoclonic Epilepsy Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Infantile Severe Myoclonic Epilepsy below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 430 products for the study of Infantile Severe Myoclonic Epilepsy that can be applied to Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.

H00006326-Q01
12.5% SDS-PAGE Stained with Coomassie Blue.


Species Human

NBP2-94559
Western Blot: SCN1B Antibody [NBP2-94559] - Analysis of extracts of various cell lines, using SCN1B at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC, IHC-P

NB300-190
Western Blot: GABA-A R gamma 2 Antibody [NB300-190] - Mouse whole brain lysate showing specific immunolabeling of the ~46 kDa gamma-2-subunit of GABAa -R.Immunohistochemistry: GABA-A R gamma 2 Antibody [NB300-190] - Immunostaining of mouse retina showing specific labeling of the GABAa gamma-2 subunit in green, calbindin in red and DNA in blue. Photo courtesy of Dr. Arlene Hirano, UCLA.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC, KD

13 Publications
NBP1-86687
Western Blot: Peripherin 2/PRPH2 Antibody [NBP1-86687] - Analysis in control (vector only transfected HEK293T lysate) and PRPH2 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).Immunohistochemistry-Paraffin: Peripherin 2/PRPH2 Antibody [NBP1-86687] - Staining of human liver shows no positivity in hepatocytes as expected.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

NBP1-82648
Western Blot: DHPS Antibody [NBP1-82648] - Analysis in control (vector only transfected HEK293T lysate) and DHPS over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).Immunocytochemistry/Immunofluorescence: DHPS Antibody [NBP1-82648] - Staining of human cell line U-2 OS shows localization to nucleoplasm, plasma membrane & cytosol. Antibody staining is shown in green.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

1 Publication
NBP1-87964
Immunohistochemistry-Paraffin: Dehydrodolichyl Diphosphate Synthase Antibody [NBP1-87964] - Staining of human Skeletal muscle shows very weak cytoplasmic positivity in myocytes.Immunohistochemistry-Paraffin: Dehydrodolichyl Diphosphate Synthase Antibody [NBP1-87964] - Staining of human Epididymis shows strong membranous and cytoplasmic positivity in glandular cells.

Rabbit Polyclonal
Species Human
Applications IHC, IHC-P

1 Publication
MAB8626
SH‑SY5Y human neuroblastoma cell line was stained with Mouse Anti-Human Protocadherin-19 Monoclonal Antibody (Catalog # MAB8626, filled histogram) or isotype control antibody (Catalog # <A class=NoLineLink href=

Mouse Monoclonal
Species Human
Applications Flow, CyTOF-ready

6510-CA


Species Human

H00009322-M01
Immunocytochemistry/Immunofluorescence: Cip4 Antibody (1A9) [H00009322-M01] - Analysis of monoclonal antibody to TRIP10 on HeLa cell. Antibody concentration 10 ug/ml.Immunoprecipitation: Cip4 Antibody (1A9) [H00009322-M01] - Analysis of TRIP10 transfected lysate using anti-TRIP10 monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with TRIP10 MaxPab rabbit polyclonal antibody.

Mouse Monoclonal
Species Human
Applications WB, ELISA, ICC/IF

NBP2-03227
Western Blot: SULT1A1 Antibody (9B7) [NBP2-03227] Analysis of extracts (35ug) from 9 different cell lines by using anti-SULT1A1 monoclonal antibody.Immunocytochemistry/Immunofluorescence: SULT1A1 Antibody (9B7) [NBP2-03227] - Staining of COS7 cells transiently transfected by pCMV6-ENTRY SULT1A1.

Mouse Monoclonal
Species Human
Applications WB, Flow, ICC/IF

NBP2-14040
Western Blot: GBGT1 Antibody [NBP2-14040] - Lane 1: Marker  [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.  Lane 2: Human cell line RT-4.  Lane 3: Human cell line U-251MG sp.  Lane 4: Human plasma (IgG/HSA depleted)Immunohistochemistry-Paraffin: GBGT1 Antibody [NBP2-14040] - Staining of human colon shows strong cytoplasmic positivity in glandular cells.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

DFN00
 Follistatin [HRP] Follistatin [HRP]


Species Human

     3 Reviews

25 Publications
NBP2-12898
Western Blot: Kv7.2 Antibody (S26A-23) [NBP2-12898] - Analysis of Human, hamster HEK and CHO cell lysates showing detection of KCNQ2 protein using Mouse Anti-KCNQ2 Monoclonal Antibody,  Load: 15 ug protein. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-KCNQ2 Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. KCNQ2 overexpressed.Immunohistochemistry-Frozen: Kv7.2 Antibody (S26A-23) [NBP2-12898] - Tissue: frozen brain section. Species: Mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-KCNQ2 Monoclonal Antibody at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 ul for 5 minutes at RT.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

NBP3-10546
Western Blot: Cytochrome P450 2C19 Antibody [NBP3-10546] - Western blot analysis using NBP3-10546 on Human Placenta  as a positive control. Antibody Titration: 0.2-1 ug/ml

Rabbit Polyclonal
Species Human
Applications WB

H00006328-Q01
12.5% SDS-PAGE Stained with Coomassie Blue.


Species Human

NBP1-74102
Western Blot: Kv7.3 Antibody [NBP1-74102] - Lanes: 100 ug CHO cell lysate Primary Antibody Dilution: 1 : 1000 Secondary Antibody: Goat anti-rabbit HRP Secondary Antibody Dilution: 1 : 25000 Gene name: Kcnq3 Submitted by: Anonymous.Western Blot: Kv7.3 Antibody [NBP1-74102] - Kv7.3 Antibody Titration: 1.0 ug/ml Positive Control: Mouse Heart.

Rabbit Polyclonal
Species Mouse, Hamster
Applications WB

1 Publication
NBP2-37502
Western Blot: Cytochrome P450 3A4 Antibody (3H8) [NBP2-37502] - Analysis using CYP3A4 mAb against HEK293 (1) and CYP3A4 (AA: 243-430)-hIgGFc transfected HEK293 (2) cell lysate.Immunocytochemistry/Immunofluorescence: Cytochrome P450 3A4 Antibody (3H8) [NBP2-37502] - Analysis of HepG2 cells using CYP3A4 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.

Mouse Monoclonal
Species Human
Applications WB, ELISA, Flow

1 Publication

Related Genes

Infantile Severe Myoclonic Epilepsy has been researched against:

Related PTMs

Infantile Severe Myoclonic Epilepsy has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Infantile Severe Myoclonic Epilepsy is also known as Dravet Syndrome, Dravet Syndromes, Severe Infantile Myoclonic Epilepsy, Severe Myoclonic Epilepsy In Infancy, Severe Myoclonic Epilepsy Of Infancy.