Epilepsy is defined as a diverse set of neurological disorders characterized by seizures. These seizures occur due to abnormal electrical activity in the brain. Factors that may lead to epilepsy include, but are not limited to, brain trauma, gene mutations, strokes, brain cancer, and extensive drug and alcohol use. Seizures occur due to a large release of glutamate, which causes a spread of excitation throughout the brain, which propagates the electrical signal and can lead to neuronal death. Idiopathic generalized epilepsy is a group of epileptic disorders that are believed to have a strong underlying genetic basis. An important gene associated with idiopathic generalized epilepsy is KCNJ10. Patients with a subtype of this disease are usually otherwise normal and lack other anatomical brain abnormalities. Patients often are genetically predisposed to seizures. The onset of idiopathic generalized epilepsy typically occurs sometime between early childhood and adolescence. The inheritance does not always follow a simple monogenic mechanism, but the genetic cause is easily obtained. About 50 million people have epilepsy, with 80% of that population located in developing countries. It is possible to control epilepsy with medicine, but many cases may require surgery in order to relieve symptoms.
Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Idiopathic Generalized Epilepsy below!
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We have 399 products for the study of Idiopathic Generalized Epilepsy that can be applied to Chromatin Immunoprecipitation, Flow Cytometry, Western Blot, Immunocytochemistry/Immunofluorescence, Chromatin Immunoprecipitation (ChIP), Immunohistochemistry from our catalog of antibodies and ELISA kits.