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Hereditary Leiomyomatosis And Renal Cell Cancer: Disease Bioinformatics

Hereditary Leimyomatosis and Renal Cell Cancer (HLRCC) is a rare (100 reported cases worldwide) disease where benign tumors containing smooth muscle tissue (leiomyomas) grow in the skin and in the uterus, for females, around the age of 30-40 years old. The tumors will present themselves all over the body and may be painful, but they are not cancerous. This condition increases the risk of kidney cancer (10-16% of individuals with HLRCC develop renal cell cancer), specifically papillary renal cell cancer type 2. In cases where renal cell cancer does not develop, the disorder may be referred to as cutaneous leiomyoatosis (MCL) or multiple cutaneous and uterine leiomyomatosis (MCUL). Hereditary leimyonatosis and renal cell cancer is caused from mutations in the FH gene which controls the creation of the enzyme fumarase, which functions in the Krebs cycle, allowing cells to use oxygen for energy. This disorder is inherited through an autosomal dominant pattern.

Hereditary Leiomyomatosis And Renal Cell Cancer Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Hereditary Leiomyomatosis And Renal Cell Cancer below! For more information on how to use Laverne, please read the How to Guide.
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Top Research Reagents

We have 1958 products for the study of Hereditary Leiomyomatosis And Renal Cell Cancer that can be applied to Western Blot, Chromatin Immunoprecipitation, Flow Cytometry, Chromatin Immunoprecipitation (ChIP), Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.

NBP1-31336
Western Blot: Fumarase Antibody [NBP1-31336] - Various whole cell extracts (30 ug) were separated by 10% SDS-PAGE, and the membrane was blotted with Fumarate hydratase antibody diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (NBP2-19301) was used to detect the primary antibody.Immunocytochemistry/Immunofluorescence: Fumarase Antibody [NBP1-31336] - HeLa cells were fixed in ice-cold MeOH for 5 min. Green: Fumarate hydratase protein stained by Fumarate hydratase antibody diluted at 1:500.Blue: Hoechst 33342 staining.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

     1 Review

1 Publication
NBP1-78159
Western Blot: LDL R Antibody (C7) [NBP1-78159] - Total protein from human HeLa and HepG2 cells was separated on a 7.5% gel by SDS-PAGE, transferred to PVDF membrane and blocked in 5% non-fat milk in TBST. The membrane was probed with 0.5 ug/mL anti-LDL receptor in 1% non-fat milk in TBST and detected with an anti-mouse HRP secondary antibody using chemiluminescence.Immunocytochemistry/Immunofluorescence: LDL R Antibody (C7) [NBP1-78159] -  Image from a customer review on porcine intestinal epithelial cells IPEC-J2.

Mouse Monoclonal
Species Human, Rat, Porcine
Applications WB, EM, ELISA

     1 Review

20 Publications
AF4779
Complement Factor H was detected in immersion fixed paraffin-embedded sections of human liver using Goat Anti-Human Complement Factor H Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4779) at 10 µg/mL overnight at 4 °C. Before incubation with the primary antibody tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # <A class=

Goat Polyclonal
Species Human
Applications WB, IHC

     2 Reviews

NBP1-44995
Western Blot: Folliculin Antibody [NBP1-44995] - Analysis of FLCN isoforms 1, 2 and 3 on HeLa whole cell lysateImmunocytochemistry/Immunofluorescence: Folliculin Antibody [NBP1-44995] - Detection of FLCN (Green) in Hela cells using NBP1-44995.  Nuclei (Blue) are counterstained using Hoechst 33258

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ICC/IF, IHC

H00007428-D01P
Western Blot: Von Hippel Lindau Antibody [H00007428-D01P] - Analysis of VHL expression in mouse lung.Immunocytochemistry/Immunofluorescence: Von Hippel Lindau Antibody [H00007428-D01P] - analysis of Von Hippel Lindau in ARPE-19 cells using anti-Von Hippel Lindau antibody. Image from verified customer review.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ICC/IF

     1 Review

NB100-105
Western Blot: HIF-1 alpha Antibody (H1alpha67) [NB100-105] - HIF-1 alpha induction by CoCl2 on Caki-1 cell lysate. Image from verified customer review.Knockout Validated: HIF-1 alpha Antibody (H1alpha67) [NB100-105] - HIF-1 alpha was detected in immersion fixed DFO treated Hela cells (left) but was not detected in HIF-1 knockout HeLa cells (right) using Mouse Anti-human HIF-1 alpha monoclonal antibody (Catalog #NB100-105) at 25 ug/mL for 3 hours at room temperature. Cells were stained using a NorthernLights (TM) 557-conjugated Donkey Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue). Specific staining was localized to nuclei.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ChIP, ELISA

     39 Reviews

835 Publications
DVE00
 VEGF [HRP] VEGF [HRP]


Species Human

     24 Reviews

507 Publications
NBP1-87069
Western Blot: SDHB Antibody [NBP1-87069] - Analysis in RT-4 cells transfected with control siRNA, target specific siRNA probe #1 and #2, using Anti-SDHB antibody. Remaining relative intensity is presented. Loading control: Anti-PPIB.Immunocytochemistry/Immunofluorescence: SDHB Antibody [NBP1-87069] - Staining of human cell line PC-3 shows localization to nucleoplasm, plasma membrane & mitochondria. Antibody staining is shown in green.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, ICC/IF

15 Publications
NBP1-87154
Western Blot: XRCC1 Antibody [NBP1-87154] - Analysis in U2OS cells transfected with control siRNA, target specific siRNA probe #1 and #2,. Remaining relative intensity is presentedImmunocytochemistry/Immunofluorescence: XRCC1 Antibody [NBP1-87154] - Staining of human cell line U-251 MG shows localization to nucleoplasm. Antibody staining is shown in green.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

AF527
    HGF R/c‑MET  was detected in immersion fixed HT‑29 human colon adenocarcinoma  cell line (positive control, left panel) and U937 human histiocytic lymphoma cell line (negative control, right  panel) using Goat Anti-Mouse HGF R/c‑MET Antigen Affinity-purified  Polyclonal Antibody (Catalog # AF527) at 5 µg/mL for 3  hours at room temperature. Cells were stained using the  NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody  (red; Catalog # <a class=HGF R/c‑MET was detected in immersion fixed frozen sections of mouse embryo (15 d.p.c.) using Goat Anti-Mouse HGF R/c‑MET Antigen Affinity-purified Polyclonal Antibody (Catalog # AF527) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # <A class=NoLineLink href=

Goat Polyclonal
Species Mouse
Applications WB, IHC, Block

     4 Reviews

21 Publications
NBP2-01506
Western Blot: Serine Dehydratase Antibody (3D3) [NBP2-01506] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY Serine Dehydratase (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by Serine Dehydratase-PAGE and immunoblotted with anti-Serine Dehydratase.Immunocytochemistry/Immunofluorescence: Serine Dehydratase Antibody (3D3) [NBP2-01506] Staining of COS7 cells transiently transfected by pCMV6-ENTRY Serine Dehydratase.

Mouse Monoclonal
Species Human
Applications WB, Flow, ICC/IF

NB100-122
Western Blot: HIF-2 alpha/EPAS1 Antibody [NB100-122] - WNT11 is induced by hypoxia or hypoxic mimetics in different cell types. Immunoblot analyses of HeLa cells under normal air or hypoxia for 24 hrs. Image collected and cropped by CiteAb from the following publication (http://www.nature.com/articles/srep21520) licensed under a CC-BY licence.Knockout Validated: HIF-2 alpha/EPAS1 Antibody [NB100-122] - HIF-1alpha is the predominant transcriptional regulator of WNT11 expression during hypoxia. EMSCs isolated from the indicated mouse genotypes were infected with lentivirus expressing GFP or Cre recombinase. Non-infected cells and GFP infected cells served as controls. Immunoblot analyses of EMSCs derived from the indicated genotypes treated with 0.1 mM DMOG for 24 hrs. Attenuated WNT11 expression in Hif-1alpha KO EMSCs (lenti-Cre infected Hif-1af/f). Image collected and cropped by CiteAb from the following publication (http://www.nature.com/articles/srep21520) licensed under a CC-BY licence.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, ChIP

     31 Reviews

626 Publications
NBP1-48336
Western Blot: Lactate Dehydrogenase A/LDHA Antibody [NBP1-48336] - Lactate Dehydrogenase A expression in porcine skeletal muscle lysate. Image from verified customer review.Immunocytochemistry/Immunofluorescence: Lactate Dehydrogenase A/LDHA Antibody [NBP1-48336] - Immunocytochemical analysis of Lactate Dehydrogenase A in HeLa cells

Rabbit Polyclonal
Species Human, Mouse, Porcine
Applications WB, Simple Western, Flow

     4 Reviews

14 Publications
NBP1-90286
Western Blot: Filamin B Antibody [NBP1-90286] - Analysis in human cell lines A-549 and HEK293 using anti-FLNB antibody. Corresponding FLNB RNA-seq data are presented for the same cell lines. Loading control: anti-HSP90B1.Immunocytochemistry/Immunofluorescence: Filamin B Antibody [NBP1-90286] - Staining of human cell line U-2 OS shows localization to plasma membrane and cytosol. Antibody staining is shown in green.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

2 Publications
NBP2-45978
Western Blot: SDSL Antibody (1A8) [NBP2-45978] - Analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SDSL.Immunohistochemistry: SDSL Antibody (1A8) [NBP2-45978] - Analysis of Human breast tissue.

Mouse monoclonal
Species Human
Applications WB, Flow, IHC

NBP2-22203
Western Blot: ERK1 Antibody (1E5) [NBP2-22203] - Western blot analysis of whole cell lysates from (1) MCF7 (2) NIH3T3 cell lines using ERK1 antibody (clone 1E5) at 1:1000 dilution. The signal was developed using HRP labeled goat-anti Mouse secondary antibody with ECL based detection. Immunocytochemistry/Immunofluorescence: ERK1 Antibody (1E5) [NBP2-22203] - Analysis of NIH/3T3 cells using ERK1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, Flow

NB110-39113
Western Blot: Glut1 Antibody [NB110-39113] - Analysis of HeLa lysates using NB110-39113. Image courtesy of Gregg Semenza (PMID: 21620138).Immunohistochemistry-Paraffin: Glut1 Antibody [NB110-39113] - Immunohistochemical analysis of FFPE tissue section of human placenta using 1:200 dilution of Glut1 antibody. The staining was developed using HRP-DAB detection method and the sections were further counterstained with hematoxylin. This antibody generated a specific strong membrane cytoplasmic staining of Glut1 primarily in the syncytiotrophoblast layers of various villi and in the red blood cells (RBCs). Cytotrophoblasts showed a very weak expression of this protein.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ChIP, Flow

     7 Reviews

32 Publications
NBP2-24716
Western Blot: MTSS1 Antibody [NBP2-24716] - Analysis of MTSS1 in human testis lysate in the 1) absence and 2) presence of immunizing peptide, 3) mouse and 4) rat testis lysate using NBP2-24716 at 2 ug/ml, 4 ug/ml and 2 ug/ml, respectively.Immunohistochemistry-Paraffin: MTSS1 Antibody [NBP2-24716] - Analysis of human colon using this antibody at 10 ug/ml.

Rabbit Polyclonal
Species Human, Mouse, Primate
Applications WB, ICC/IF, IHC

1 Publication
H00008731-M01
Western Blot: RNMT Antibody (3H3-1D12) [H00008731-M01] - RNMT monoclonal antibody (M01), clone 3H3-1D12 Analysis of RNMT expression in HeLa.Immunocytochemistry/Immunofluorescence: RNMT Antibody (3H3-1D12) [H00008731-M01] - Analysis of monoclonal antibody to RNMT on HeLa cell. Antibody concentration 10 ug/ml.

Mouse Monoclonal
Species Human
Applications WB, ELISA, ICC/IF


Related Genes

Hereditary Leiomyomatosis And Renal Cell Cancer has been researched against:

Related PTMs

Hereditary Leiomyomatosis And Renal Cell Cancer has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Hereditary Leiomyomatosis And Renal Cell Cancer is also known as hereditary leiomyomatosis and renal cell cancer, hlrcc, uterine fibroids, leiomyomatosis and renal cell cancer, hereditary, lrcc, hereditary leiomyomatosis and renal cell carcinoma, multiple cutaneous and uterine leiomyomata, leiomyomatosis and renal cell cancer, leiomyoma, multiple cutaneous, multiple cutaneous leiomyoma, reed's syndrome, uterine fibroid, leiomyomatosis, mcul, mcl.