Hereditary Breast And Ovarian Cancer Syndrome: Disease Bioinformatics
Hereditary Breast and Ovarian Cancer Syndrome (HBOC) is a rare (only 5-10% of total cancer cases) inherited disorder that produces higher than average levels of breast and ovarian cancer and is characterized by an early onset of cancer, a family history of breast and ovarian cancer, autosomal dominant pattern of inheritance, and a frequent occurrence of bilateral cancer. HBOC is the product of mutations on the BRCA1 (found on chromosome 17) and BRCA2 (found of chromosome 13) genes. These genes are known tumor suppressors that control cell growth and death. Because these genes are not located on the sex chromosomes, the inherited mutations may be passed from one generation to another either through the mother or the father. Interestingly, the Ashkenazi Jewish population tends to have the highest occurrence of hereditary breast and ovarian cancer syndrome. Other risk factors include oral contraceptives, hormone replacement therapy, radiation exposure, alcohol intake, and obesity. Because this is a genetic disorder, these risk factors simply may assist in the cancer's onset.
Hereditary Breast And Ovarian Cancer Syndrome Bioinformatics Tool
Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Hereditary Breast And Ovarian Cancer Syndrome below!
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We have 1775 products for the study of Hereditary Breast And Ovarian Cancer Syndrome that can be applied to Chromatin Immunoprecipitation, Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Chromatin Immunoprecipitation (ChIP), Immunohistochemistry from our catalog of antibodies and ELISA kits.