Familial Hypercholesterolemia Due To Genetic Defect Of Apolipoprotein B: Disease Bioinformatics
Hypercholesterolemia (also known as high cholesterol) occurs when abnormally high levels of certain types of cholesterol are in the blood (>5.2 mmol/L). This increase of cholesterol can cause plaque buildup in the artery walls, inevitably causing damage to organs and tissues when blood flow is restricted. Borderline hypercholesterolemia is defined when levels are between 200-239 mg/dL. Hypercholesterolemia is significantly correlated with increased incidence and risk of atherosclerosis, heart attack, and stroke. Risk is increased with smoking, diabetes, high blood pressure, obesity, and poor exercise in combination with a poor diet. Familial hypercholesterolemia is a genetic disorder that is inherited, making prevalence within a family approximately 50%. This type of hypercholesterolemia is due to a genetic defect of apolipoprotein B, hence the name familial hypercholesterolemia type B. HDL (high-density lipoprotein) is a type of cholesterol, commonly known as "good" cholesterol, that fights artery-clogging LDL (low density lipoprotein) cholesterol by flushing LDL into the liver for disposal. Eating unsaturated fat will increase HDL levels. Treatments focus on reducing the risk of cardiovascular disease by decreasing blood cholesterol levels. Medications may be diagnosed to help with this process.
Familial Hypercholesterolemia Due To Genetic Defect Of Apolipoprotein B Bioinformatics Tool
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