Epilepsy is defined as a diverse set of neurological disorders characterized by seizures. These seizures occur due to abnormal electrical activity in the brain. Factors that may lead to epilepsy include, but are not limited to, brain trauma, gene mutations, strokes, brain cancer, and extensive drug and alcohol use. Seizures occur due to a large release of glutamate, which causes a spread of excitation throughout the brain, which propagates the electrical signal and can lead to neuronal death. Familial benign neonatal epilepsy is a rare autosomal dominant form of epilepsy, which is caused by mutations in the KCNQ2 and KCNQ3 genes, as well as by a chromosomal inversion. Seizures typically occur in newborns during their first seven days of life, and spontaneously stop within fifteen weeks. The child’s susceptibility to seizures is increased to 16%, compared to 2% of normal children, but there are no other side effects. About 50 million people have epilepsy, with 80% of that population located in developing countries. It is possible to control epilepsy with medicine, but many cases may require surgery in order to relieve symptoms.
Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Familial Benign Neonatal Epilepsy below!
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We have 281 products for the study of Familial Benign Neonatal Epilepsy that can be applied to Flow Cytometry, Western Blot, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.
![Western Blot: Kv7.2 Antibody (S26A-23) [NBP2-12898] - Analysis of Human, hamster HEK and CHO cell lysates showing detection of KCNQ2 protein using Mouse Anti-KCNQ2 Monoclonal Antibody, Load: 15 ug protein. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-KCNQ2 Monoclonal Antibody at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. KCNQ2 overexpressed.](http://images.novusbio.com/fullsize2/Kv7.2-Antibody-(S26A-23)-Western-Blot-NBP2-12898-img0009.jpg)
![Immunohistochemistry-Frozen: Kv7.2 Antibody (S26A-23) [NBP2-12898] - Tissue: frozen brain section. Species: Mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-KCNQ2 Monoclonal Antibody at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 ul for 5 minutes at RT.](http://images.novusbio.com/fullsize2/Kv7.2-Antibody-(S26A-23)-Immunohistochemistry-Frozen-NBP2-12898-img0010.jpg)
![Western Blot: Kv7.3 Antibody [NBP1-74102] - Lanes: 100 ug CHO cell lysate Primary Antibody Dilution: 1 : 1000 Secondary Antibody: Goat anti-rabbit HRP Secondary Antibody Dilution: 1 : 25000 Gene name: Kcnq3 Submitted by: Anonymous.](http://images.novusbio.com/fullsize2/Kv7.3 Antibody-Western Blot-NBP1-74102-img0004.jpg)
![Western Blot: Kv7.3 Antibody [NBP1-74102] - Kv7.3 Antibody Titration: 1.0 ug/ml Positive Control: Mouse Heart.](http://images.novusbio.com/fullsize2/Kv7.3-Antibody-Western-Blot-NBP1-74102-img0003.jpg)
![Western Blot: Nicotinic Acetylcholine R alpha 4/CHRNA4 Antibody (7B4H1) [NBP2-61674] - Analysis using CHRNA4 mAb against HEK293 (1) and CHRNA4 (AA: 29-242)-hIgGFc transfected HEK293 (2) cell lysate.](http://images.novusbio.com/fullsize2/Nicotinic-Acetylcholine-R-alpha-4-CHRNA4-Antibody-(7B4H1)-Western-Blot-NBP2-61674-img0003.jpg)
![Flow Cytometry: Nicotinic Acetylcholine R alpha 4/CHRNA4 Antibody (7B4H1) [NBP2-61674] - Analysis using CHRNA4 mouse mAb against SH-SY5Y (1) cell lysate.](http://images.novusbio.com/fullsize2/Nicotinic Acetylcholine R alpha 4-CHRNA4 Antibody (7B4H1)-Flow Cytometry-NBP2-61674-img0004.jpg)
![Immunocytochemistry/Immunofluorescence: Scn1a Antibody [NBP2-58876] - Staining of human cell line ASC TERT1 shows localization to nucleoplasm & plasma membrane. Antibody staining is shown in green.](http://images.novusbio.com/fullsize2/Scn1a Antibody-Immunocytochemistry-Immunofluorescence-NBP2-58876-img0001.jpg)
![Western Blot: Kv7.1 Antibody (S37A-10) [NBP2-12897] - analysis of hamster T-CHO cell lysate showing detection of KCNQ1 protein using Mouse Anti-KCNQ1 Monoclonal Antibody, Clone S37A-10. Load: 15 ug protein. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-KCNQ1 Monoclonal Antibody at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT.](http://images.novusbio.com/fullsize2/Kv7.1-Antibody-(S37A-10)-Western-Blot-NBP2-12897-img0008.jpg)
![Immunohistochemistry: Kv7.1 Antibody (S37A-10) [NBP2-12897] - Tissue: hippocampus. Species: Human. Fixation: Bouin's Fixative and paraffin-embedded. Primary Antibody: Mouse Anti-KCNQ1 Monoclonal Antibody at 1:1000 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT.](http://images.novusbio.com/fullsize2/Kv7.1-Antibody-(S37A-10)-Immunohistochemistry-NBP2-12897-img0009.jpg)
![Western Blot: SCN1B Antibody [NBP2-94559] - Analysis of extracts of various cell lines, using SCN1B at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.](http://images.novusbio.com/fullsize2/SCN1B Antibody-Western Blot-NBP2-94559-img0001.jpg)
![Immunocytochemistry/Immunofluorescence: Kv7.5 Antibody [NBP1-82861] - Staining of human cell line U-2 OS shows localization to vesicles. Antibody staining is shown in green.](http://images.novusbio.com/fullsize2/Kv7.5 Antibody-Immunocytochemistry-Immunofluorescence-NBP1-82861-img0011.jpg)
![Immunohistochemistry-Paraffin: Kv7.5 Antibody [NBP1-82861] - Staining in human cerebral cortex and pancreas tissues using anti-KCNQ5 antibody. Corresponding KCNQ5 RNA-seq data are presented for the same tissues.](http://images.novusbio.com/fullsize2/Kv7.5-Antibody-Immunohistochemistry-Paraffin-NBP1-82861-img0010.jpg)
![Western Blot: PRRT2 Antibody [NBP2-82026] - Analysis of PRRT2 in mouse brain tissue lysate with PRRT2 antibody at 1 ug/ml.](http://images.novusbio.com/fullsize2/PRRT2-Antibody-Western-Blot-NBP2-82026-img0001.jpg)
![Immunocytochemistry/Immunofluorescence: PRRT2 Antibody [NBP2-82026] - Immunofluorescence of PRRT2 in rat brain tissue with PRRT2 antibody at 20 ug/ml.](http://images.novusbio.com/fullsize2/PRRT2-Antibody-Immunocytochemistry-Immunofluorescence-NBP2-82026-img0003.jpg)
![Western Blot: Kv7.4 Antibody (S43-6) [NBP2-12899] - analysis of Rat tissue lysate showing detection of KCNQ4 protein using Mouse Anti-KCNQ4 Monoclonal Antibody, Clone S43-6. Load: 15 ug protein. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-KCNQ4 Monoclonal Antibody at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT.](http://images.novusbio.com/fullsize2/Kv7.4-Antibody-(S43-6)-Western-Blot-NBP2-12899-img0007.jpg)
![Immunohistochemistry-Frozen: Kv7.4 Antibody (S43-6) [NBP2-12899] - Tissue: frozen brain section. Species: mouse. Fixation: 10% Formalin Solution for 12-24 hours at RT. Primary Antibody: Mouse Anti-KCNQ4 Monoclonal Antibody at 1:1000 for 1 hour at RT. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown) for 30 minutes at RT. Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain at 250-500 ul for 5 minutes at RT.](http://images.novusbio.com/fullsize2/Kv7.4-Antibody-(S43-6)-Immunohistochemistry-Frozen-NBP2-12899-img0006.jpg)
![Western Blot: Recombinant Human Lgi1 Protein [H00009211-P01] - The human recombinant LGI1 protein is recognized by a commercial antibody against LGI1. Lane 2: 0.4 ug; Lane 3: 0.2 ug). Lane 4: no protein. Image from verified customer review.](http://images.novusbio.com/fullsize2/Recombinant-Human-Lgi1-Protein-Western-Blot-H00009211-P01-img0002.jpg)
![Recombinant Human Lgi1 Protein [H00009211-P01] - 12.5% SDS-PAGE Stained with Coomassie Blue.](http://images.novusbio.com/fullsize2/Recombinant-Human-Lgi1-Protein-H00009211-P01-img0001.jpg)
![Western Blot: GABA-A R gamma 2 Antibody [NB300-151] - 10 ug of rat brain lysate showing immunolabeling of the ~45-47 kDa GABA - A R, g2-subunit.](http://images.novusbio.com/fullsize2/GABA-A-R-gamma-2-Antibody-Western-Blot-NB300-151-img0007.jpg)
![Immunohistochemistry-Paraffin: GABA-A R gamma 2 Antibody [NB300-151] - Rat cerebellum.](http://images.novusbio.com/fullsize2/GABA-A-R-gamma-2-Antibody-Immunohistochemistry-Paraffin-NB300-151-img0005.jpg)
![Western Blot: Carbonic Anhydrase I/CA1 Antibody [NBP1-88191] - Comparative proteome analysis of 3xTg-AD and control samples at different stages of AD. Immunoblot analysis of most regulated hits. Soluble fractions of brain proteins were analyzed from four 2-month-old control and 3xTg-AD mice animals, respectively. Hebp1 and Glo1 levels were consistently elevated in the transgenic animals as compared to wild type controls. Ca1 levels were reduced in transgenic animals. Image collected and cropped by CiteAb from the following publication (https://elifesciences.org/articles/47498), licensed under a CC-BY licence.](http://images.novusbio.com/fullsize2/Carbonic Anhydrase I-CA1 Antibody-Western Blot-NBP1-88191-img0015.jpg)
![Immunohistochemistry-Paraffin: Carbonic Anhydrase I/CA1 Antibody [NBP1-88191] - Staining of human rectum shows strong cytoplasmic and nuclear positivity in glandular cells.](http://images.novusbio.com/fullsize2/Carbonic-Anhydrase-I-CA1-Antibody-Immunohistochemistry-Paraffin-NBP1-88191-img0014.jpg)
![Western Blot: PSMC1 Antibody [NBP1-80959] - Western blot analysis in mouse cell line NIH-3T3, rat cell line NBT-II and rat cell line pC12.](http://images.novusbio.com/fullsize2/PSMC1 Antibody-Western Blot-NBP1-80959-img0010.jpg)
![Immunocytochemistry/Immunofluorescence: PSMC1 Antibody [NBP1-80959] - Staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol. Antibody staining is shown in green.](http://images.novusbio.com/fullsize2/PSMC1-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-80959-img0008.jpg)
![Western Blot: Kv1.1 Antibody [NBP2-80429] - Analysis of Kv1.1 on rat brain tissue lysate. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in PBS for 1 hour at room temperature. The primary antibody (NBP2-80429, 1/500) was used in 5% BSA at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody at 1:5,000 dilution was used for 1 hour at room temperature.](http://images.novusbio.com/fullsize2/Kv1.1-Antibody-Western-Blot-NBP2-80429-img0004.jpg)
![Immunohistochemistry-Paraffin: Kv1.1 Antibody [NBP2-80429] - Analysis in mouse brain tissue using Kv1.1 antibody. The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with dd](http://images.novusbio.com/fullsize2/Kv1.1-Antibody-Immunohistochemistry-Paraffin-NBP2-80429-img0003.jpg)
![SDS-Page: Recombinant Human RPS4Y1 Protein [H00006192-P01] - 12.5% SDS-PAGE Stained with Coomassie Blue.](http://images.novusbio.com/fullsize/qc_test-H00006192-P01-1.jpg)
![Western Blot: RPS4X Antibody [NBP2-94118] - Analysis of extracts of various cell lines, using RPS4X at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.](http://images.novusbio.com/fullsize2/RPS4X Antibody-Western Blot-NBP2-94118-img0002.jpg)
![Immunohistochemistry-Paraffin: RPS4X Antibody [NBP2-94118] - Paraffin-embedded human kidney using RPS4X.](http://images.novusbio.com/fullsize2/RPS4X-Antibody-Immunohistochemistry-Paraffin-NBP2-94118-img0001.jpg)
