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Experimental Autoimmune Encephalomyelitis: Disease Bioinformatics

Experimental Autoimmune Encephalomyelitis (EAE) is an experimental model most frequently used for research on demyelinating diseases such as Multiple Sclerosis (MS) and can be used as a model of cell-mediated organ-specific autoimmune conditions in general. Experimental Autoimmune Encephalomyelitis has been used to develop many medications for such diseases. Autoimmune Encephalomyelitis is an induced autoimmune disorder that creates inflammation in the brain and spinal cord.

Experimental Autoimmune Encephalomyelitis Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Experimental Autoimmune Encephalomyelitis below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 2716 products for the study of Experimental Autoimmune Encephalomyelitis that can be applied to Chromatin Immunoprecipitation, Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence from our catalog of antibodies and ELISA kits.

NB600-717
Western Blot: MBP Antibody (12) [NB600-717] - Mouse Brain Tissue lysate probed with Rat anti MBP.

Rat Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, ICC/IF

     1 Review

12 Publications
H00004340-B01P
Western Blot: MOG Antibody [H00004340-B01P] - Analysis of MOG expression in rat brain.Western Blot: MOG Antibody [H00004340-B01P] - Analysis of MOG expression in transfected 293T cell line by MOG polyclonal antibody.  Lane 1: MOG transfected lysate(32.56 KDa). Lane 2: Non-transfected lysate.

Mouse Polyclonal
Species Human, Rat
Applications WB

     1 Review

AF2307

Goat Polyclonal
Species Human
Applications WB, ELISA(Cap), ELISA(Det)

5 Publications
NBP2-19928
Western Blot: PRG2 Antibody [NBP2-19928] - Sample (30 ug of whole cell lysate) A: Jurkat B: K562 C: THP-1 D: HL-60 12% SDS PAGE gel, diluted at 1:1000.Immunohistochemistry-Paraffin: PRG2 Antibody [NBP2-19928] - Immunohistochemical analysis of paraffin-embedded Hepatoma, using antibody at 1:500 dilution.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

210-TA/CF
Recombinant Human TNF-alpha  (Catalog # 210‑TA/CF) induces cytotoxicity in the L-929 mouse fibroblast cell line in the presence of the metabolic inhibitor actinomycin D. The ED<sub>50</sub> for this effect is 25‑100 pg/mL.1 µg/lane of Recombinant Human TNF-alpha  was resolved by SDS-PAGE with silver staining, under reducing (R) conditions, showing a band at 17 kDa.


Species Human

428 Publications
NBP1-19371
Western Blot: CD4 Antibody [NBP1-19371] - CD4 antibody was tested in the following cell lysates: Lane 1) human spleen 2) human tonsil 3) human placenta 4) human kidney 5) human liver 6) mouse spleen 7) mouse placenta 8) rat placenta.Immunocytochemistry/Immunofluorescence: CD4 Antibody [NBP1-19371] - CD4 antibody was tested in Jurkat cells with Dylight 488 (green). Nuclei were counterstained with DAPI (blue).

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, ICC/IF

     6 Reviews

13 Publications
285-IF/CF
1 μg/lane of Recombinant Human IFN-gamma  was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 17 kDa.Recombinant Human IFN-gamma  (Catalog # 285‑IF/CF) demonstrates anti-viral activity in HeLa human cervical epithelial carcinoma cells infected with encephalomyocarditis (EMC) virus. The ED<SUB>50</SUB> for this effect is 0.15‑0.75 ng/mL.


Species Human

219 Publications
204-IL/CF
Recombinant Human IL-4 (Catalog # 204‑IL/CF) stimulates cell proliferation of the TF-1 human erythroleukemic cell line. The ED<SUB>50</SUB> for this effect is 0.05‑02 ng/mL. 1 μg/lane of Recombinant Human IL-4 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 14 kDa.


Species Human

259 Publications
202-IL/CF
1 μg/lane of Recombinant Human IL-2 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 13 kDa.Recombinant Human IL-2 (Catalog # 202-IL/CF) stimulates cell proliferation of the CTLL‑2 mouse cytotoxic T cell line. The ED<SUB>50</SUB> for this effect is 0.05-0.25 ng/mL.


Species Human

207 Publications
538-MG


Species Rat

     1 Review

13 Publications
NBP1-87781
Western Blot: Myelin PLP Antibody [NBP1-87781] - Analysis in control (vector only transfected HEK293T lysate) and pLP1 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).Immunohistochemistry-Paraffin: Myelin PLP Antibody [NBP1-87781] - Analysis in human cerebral cortex and pancreas tissues using Anti-PLP1 antibody. Corresponding PLP1 RNA-seq data are presented for the same tissues.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

     1 Review

1 Publication
AF-386-PB
    Western  blot shows lysates of NS0 mouse myeloma cell line either mock transfected or  transfected with human <br>CTLA-4. PVDF membrane was probed with  0.5 µg/mL of Goat Anti-Human CTLA‑4 Antigen  Affinity-purified Polyclonal Antibody (Catalog # AF-386-PB) followed by  HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class=CTLA‑4 was detected in immersion fixed human peripheral blood mononuclear cells treated with treated with PMA and calcium ionomycin using Goat Anti-Human CTLA‑4 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-386-PB) at 15 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # <a class=

Goat Polyclonal
Species Human
Applications WB, Flow, CyTOF-ready

     2 Reviews

2 Publications
AF5724
Western blot shows lysates of human, mouse, and rat brain tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse/Rat Peroxiredoxin 5 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5724) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class=    Peroxiredoxin 5  was detected in immersion fixed A549 human lung carcinoma cell line using  Goat Anti-Human/Mouse/Rat Peroxiredoxin 5 Antigen Affinity-purified  Polyclonal Antibody (Catalog # AF5724) at 10 µg/mL for 3  hours at room temperature. Cells were stained using the  NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody  (red; Catalog # <a class=

Goat Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC

NBP2-27461
Western Blot: PDXP Antibody [NBP2-27461] - 0.1 ug/ml staining of Mouse (A) and Rat (B) Brain lysates (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Western Blot: PDXP Antibody [NBP2-27461] - NBP2-27461 (0.1ug/ml) staining of Human Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Goat Polyclonal
Species Human, Mouse, Rat
Applications WB, PEP-ELISA

1 Publication
NBP2-35224
SDS-Page: Human PTHLH/PTHrP Protein [NBP2-35224]


Species Human

NB120-6405
Immunocytochemistry/Immunofluorescence: MHC Class I Antibody (OX18) [NB120-6405] - PC-12 cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.5% Triton-X100. The cells were incubated with anti-MHC Class I (OX18) NB120-6405 at a 1:100 dilution overnight at 4C and detected with an anti-mouse Dylight 488 (Green) at a 1:500 dilution. Actin was detected with Phalloidin 568 (Red) at a 1:200 dilution. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 40X objective.Immunohistochemistry-Paraffin: MHC Class I Antibody (OX18) [NB120-6405] -  IHC analysis of formalin fixed paraffin-embedded (FFPE) rat brain cerebellum using MHC Class I (OK18) antibody at 1:200 on a Bond Rx autostainer (Leica Biosystems). The assay involved 20 minutes of heat induced antigen retrieval (HIER) using 10mM sodium citrate buffer (pH 6.0) and endogenous peroxidase quenching with peroxide block. The sections were incubated with primary antibody for 30 minutes and Bond Polymer Refine Detection (Leica Biosystems) with DAB was used for signal development followed by counterstaining with hematoxylin. Whole slide scanning and capturing of representative images was performed using Aperio AT2 (Leica Biosystems). Endothelial staining was observed. Staining was performed by Histowiz.

Mouse Monoclonal
Species Rat
Applications B/N, ELISA, Flow

29 Publications
NBP2-02905
Western Blot: B7-1/CD80 Antibody (2E5) [NBP2-02905] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CD80 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CD80.Immunocytochemistry/Immunofluorescence: B7-1/CD80 Antibody (2E5) [NBP2-02905] - Staining of COS7 cells transiently transfected by pCMV6-ENTRY CD80.

Mouse Monoclonal
Species Human, Monkey
Applications WB, ICC/IF, IHC

     1 Review


Related Genes

Experimental Autoimmune Encephalomyelitis has been researched against:

Alternate Names

Experimental Autoimmune Encephalomyelitis is also known as Autoimmune Experimental Encephalomyelitis, Eae, Encephalomyelitis, Experimental Allergic, Encephalomyelitis, Experimental Autoimmune, Experimental Allergic Encephalomyelitis.