Epilepsy With Continuous Spike Wave During Slow-wave Sleep: Disease Bioinformatics
Epilepsy is defined as a diverse set of neurological disorders characterized by seizures. These seizures occur due to abnormal electrical activity in the brain. Factors that may lead to epilepsy include, but are not limited to, brain trauma, gene mutations, strokes, brain cancer, and extensive drug and alcohol use. Seizures occur due to a large release of glutamate, which causes a spread of excitation throughout the brain, which propagates the electrical signal and can lead to neuronal death. For epilepsy with continuous spike wave during slow-wave sleep (CSWS), onset generally occurs between ages 1 and 10 years. One-third of patients experience developmental delays, predominantly in language. During CSWS, atypical absence seizures and atonic seizures predominate as the epilepsy becomes severe. A diffuse spike and wave pattern appears on the EEG. CSWS appears during non-rapid eye movement (non-REM) sleep. About 50 million people have epilepsy, with 80% of that population located in developing countries. It is possible to control epilepsy with medicine, but many cases may require surgery in order to relieve symptoms.
Epilepsy With Continuous Spike Wave During Slow-wave Sleep Bioinformatics Tool
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