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Epilepsy, Temporal Lobe: Disease Bioinformatics

Epilepsy is defined as a diverse set of neurological disorders characterized by seizures. These seizures occur due to abnormal electrical activity in the brain. Factors that may lead to epilepsy include, but are not limited to, brain trauma, gene mutations, strokes, brain cancer, and extensive drug and alcohol use. Seizures occur due to a large release of glutamate, which causes a spread of excitation throughout the brain, which propagates the electrical signal and can lead to neuronal death. Temporal lobe epilepsy is one of the most common forms of focal epilepsy, a chronic neurological condition characterized by recurrent seizures. Medial temporal lobe epilepsy arises in the hippocampus, parahippocampal gyrus and amygdala which are located in the inner portion of the temporal lobe. Lateral temporal lobe epilepsy arises in the neocortex on the outer surface of the temporal lobe. About 50 million people have epilepsy, with 80% of that population located in developing countries. It is possible to control epilepsy with medicine, but many cases may require surgery in order to relieve symptoms.

Epilepsy, Temporal Lobe Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Epilepsy, Temporal Lobe below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 870 products for the study of Epilepsy, Temporal Lobe that can be applied to Flow Cytometry, Western Blot, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.

AF2180
    Simple  Western lane view shows lysates of HEL 92.1.7 human erythroleukemic  cell line and human liver tissue, loaded at 0.2 mg/mL. A specific  band was detected for Carbonic Anhydrase I/CA1 at approximately  38 kDa (as indicated) using 5 µg/mL of Goat Anti-Human  Carbonic Anhydrase I/CA1 Antigen Affinity-purified Polyclonal  Antibody (Catalog # AF2180) followed by 1:50 dilution of HRP-conjugated  Anti-Goat IgG Secondary Antibody (Catalog # <a class=    Western  blot shows lysates of HEL 92.1.7 human erythroleukemic cell line,  human liver tissue, and human colon tissue. PVDF membrane was probed with  0.1 µg/mL of Goat Anti-Human Carbonic Anhydrase I/CA1  Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2180) followed by  HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class=

Goat Polyclonal
Species Human
Applications WB, Simple Western, IP

AF2185
    Western  blot shows lysates of human, mouse, and rat skeletal muscle tissue and heart tissue. PVDF  membrane was probed with 0.1 µg/mL of Goat Anti-Human/Mouse/<br>Rat Carbonic  Anhydrase III/CA3 Antigen Affinity-purified Polyclonal Antibody  (Catalog # AF2185) followed by HRP-conjugated Anti-Goat IgG Secondary  Antibody (Catalog # <a class=

Goat Polyclonal
Species Human, Mouse, Rat
Applications WB, IP

1 Publication
NBP1-51843
Western Blot: Aurora A Antibody [NBP1-51843] - WB detection of Aurora A in HeLa whole cell lysate.Immunocytochemistry/Immunofluorescence: Aurora A Antibody [NBP1-51843] - IF Confocal analysis of HeLa cells using Aurora A antibody (NBP1-51843, 1:10). An Alexa Fluor 488-conjugated Goat to rabbit IgG was used as secondary antibody (green). Actin filaments were labeled with Alexa Fluor 568 phalloidin (red). DAPI was used to stain the cell nuclei (blue).

Rabbit Polyclonal
Species Human, Mouse
Applications WB, Simple Western, ICC/IF

     1 Review

4 Publications
NB300-141
Immunocytochemistry/Immunofluorescence: GFAP Antibody [NB300-141] - ICC-IF analysis of mixed neuron-glial cultures using GFAP antibody NB300-141 (red) and Vimentin antibody NB300-223 (green). The fibroblastic cells contain only Vimentin and so are green.  The astrocytes contain either Vimentin and GFAP (appearing golden) or predominantly GFAP (appearing red). Blue is nuclear DNA stain.Immunocytochemistry/Immunofluorescence: GFAP Antibody [NB300-141] - Rat neurons stained with Neurofilament Heavy antibody NB300-217 (red) and GFAP antibody NB300-141 (green).

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, ICC/IF

     4 Reviews

32 Publications
NBP1-80775
Immunohistochemistry-Paraffin: Fucosyltransferase 2/FUT2 Antibody [NBP1-80775] - Staining of human duodenum shows cytoplasmic positivity in glandular cells.

Rabbit Polyclonal
Species Human
Applications IHC, IHC-P

NBP2-32001
Immunohistochemistry-Paraffin: SQLE Antibody [NBP2-32001] - Staining of human testis shows strong cytoplasmic positivity in Leydig cells.

Rabbit Polyclonal
Species Human, Mouse
Applications IHC, IHC-P

1 Publication
NBP2-56762
Western Blot: Adenine Nucleotide Translocator 2 Antibody [NBP2-56762] - Western blot analysis in human cell line RT-4 and human cell line U-251 MG.Immunocytochemistry/Immunofluorescence: Adenine Nucleotide Translocator 2 Antibody [NBP2-56762] - Staining of human cell line PC-3 shows localization to mitochondria.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF

NBP1-32244
Western Blot: Calretinin Antibody [NBP1-32244] - Rat tissue extract (50 ug) was separated by 12% SDS-PAGE, and the membrane was blotted with Calretinin antibody diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (NBP2-19301) was used to detect the primary antibody.Immunocytochemistry/Immunofluorescence: Calretinin Antibody [NBP1-32244] - Analysis of paraformaldehyde-fixed A431, using Calretinin (GTX103261) antibody at 1:200 dilution.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

NBP1-46535

Goat Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC, IHC-Fr

6 Publications
NBP1-77320
Western Blot: Lgi1 Antibody [NBP1-77320] - HeLa cell lysate with LGI1 antibody at 2 ug/ml.Immunohistochemistry-Paraffin: Lgi1 Antibody [NBP1-77320] - Human brain tissue using LGI1 antibody at 2.5 ug/ml.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ELISA, IHC

NBP1-89285
Western Blot: ACAT1 Antibody [NBP1-89285] - Analysis in mouse cell line NIH-3T3 and rat cell line NBT-II.Immunocytochemistry/Immunofluorescence: ACAT1 Antibody [NBP1-89285] - Immunofluorescent staining of human cell line A-431 shows localization to mitochondria.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

3 Publications
248-BD/CF
1 μg/lane of Recombinant Human BDNF was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 13 kDa.Recombinant Human BDNF (Catalog #<br>248‑BD/CF) stimulates cell proliferation in the BaF mouse pro-B cell line transfected with TrkB. The ED<sub>50</sub> for this effect is 0.2-2 ng/mL.


Species Human, Mouse, Rat

77 Publications
NB110-41404
Western Blot: Glutamine Synthetase Antibody [NB110-41404] - Analysis of glutamine synthase. 40ug of lysates from mouse (Lanes M), rat (Lanes R), pig (Lanes P), bovine (Lanes B), or human (Lanes Hu) retina were probed. A 42 kDa band was identified in lysates from retinas of all species.Immunohistochemistry: Glutamine Synthetase Antibody [NB110-41404] - Localization of glutamine synthase in the retina. Paraffin sections of mouse (A, B), rat (C, D, G-I), or human (E, F) retina fixed in 4% paraformaldehyde were reacted with anti-glutamine synthase (red fluorescence staining in B, D, G, I, and brown immuno-peroxidase reaction [using ABC kit and visualization with DAB product in F]. Nuclei in some immunofluorescence experiments (A-D) were stained with DAPI (shown in cyan), and with nuclear fast red in E and F.  On inspection at low magnification, anti- glutamine synthase reacted with a single population of cells extending from the ganglion cell layer (GCL) through the inner nuclear layer (INL). No signal was detected in controls either pre-incubated with 100ug/ml of the immunizing peptide (A) or with pre-immune serum (C, E). The pattern of staining observed in all experiments is typicals. This finding was confirmed by co-localization (indicated by yellow in I) of glutamine synthase (red in G) with antoher marker of glutamine synthase (green in H).

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC

     1 Review

1 Publication
AF2009
CD55/DAF was detected in immersion fixed paraffin-embedded sections of human colon cancer tissue using 15 µg/mL Goat Anti-Human CD55/DAF Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2009) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # <A class=NoLineLink href=

Goat Polyclonal
Species Human
Applications WB, IHC

3 Publications
NB600-919
Western Blot: Carbonic Anhydrase II/CA2 Antibody [NB600-919] - Lane 1: Carbonic Anhydrase II. Lane 2: None. Load: 50 ng per lane. Primary antibody: Carbonic Anhydrase II primary antibody at 1:1,000 overnight at 4C. Secondary antibody: Peroxidase rabbit secondary antibody at 1:40,000 for 30 min at RT. Blocking: incubated with blocking buffer for 30 min at RT. Predicted/Observed size: 29 kDa, 29 kDa for Carbonic Anhydrase II. Other band(s): None.Immunohistochemistry: Carbonic Anhydrase II/CA2 Antibody [NB600-919] - Staining in nucleus and cytoplasm of proximal and distal tubules, bowman's capsule and glomerular podocytes of human kidney (B) and in basal cells of retina of a mouse eye (C). Formalin fixed/paraffin embedded sections were subjected to heat induced epitope retrieval (HIER) at pH 6.2 and then incubated with rabbit anti-carbonic anhydrase II antibody at 4.0 ug/ml for 60 minutes. The reaction was developed using either MACH 1 universal HRP polymer detection (human kidney) or MACH 4 universal AP polymer detection system (mouse eye) and visualized with 3'3-diamino-benzidine substrate (DAB) or WARP RED.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ELISA, IHC

     3 Reviews

5 Publications
MAB4909
Western blot shows lysates of human spleen tissue. PVDF Membrane was probed with 2 µg/mL of Mouse Anti-Human CD21 Monoclonal Antibody (Catalog # MAB4909) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # <a class=Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human CD19 PE‑conjugated Monoclonal Antibody (Catalog # <a class=

Mouse Monoclonal
Species Human
Applications WB, Flow, CyTOF-ready

1 Publication
NBP1-83790
Western Blot: DHRS4 Antibody [NBP1-83790] - Lane 1: Marker  [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.  Lane 2: Human cell line RT-4.  Lane 3: Human cell line U-251MG spImmunocytochemistry/Immunofluorescence: DHRS4 Antibody [NBP1-83790] - Staining of human cell line A-431 shows positivity in nuclear membrane and vesicles.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

NB100-1598
Western Blot: CRIPTO Antibody [NB100-1598] - Analysis of Cripto in Dicer knockout mouse embryonic stem cell lysate.Immunocytochemistry/Immunofluorescence: CRIPTO Antibody [NB100-1598] - CRIPTO  antibody was tested in HeLa cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red).

Rabbit Polyclonal
Species Human, Mouse
Applications WB, Flow, ICC/IF

2 Publications
MAB2358
Somatostatin was detected in immersion fixed human embryonic stem cells differentiated to pancreatic cells using Rat Anti-Human Somatostatin Monoclonal Antibody (Catalog # MAB2358) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Rat IgG Secondary Antibody (red; Catalog # <a class=Somatostatin was detected in immersion fixed  beta TC‑6 mouse beta cell insulinoma cell line using Rat Anti-Human Somatostatin Monoclonal Antibody (Catalog # MAB2358) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Rat IgG Secondary Antibody (red; Catalog # <a class=

Rat Monoclonal
Species Human, Mouse
Applications IHC, ICC

AF2086
    Western  blot shows lysates of human brain (hypothalamus) tissue, mouse brain (total)  tissue, and rat brain (total) tissue. PVDF membrane was probed with  1 µg/mL of Goat Anti-Human/Mouse/Rat GAD1/GAD67 Antigen Affinity-purified  Polyclonal Antibody (Catalog # AF2086) followed by HRP-conjugated Anti-Goat  IgG Secondary Antibody (Catalog # <a class=GAD1/GAD67 was detected in immersion fixed paraffin-embedded sections of human spinal cord using 15 µg/mL Goat Anti-Human/Mouse/Rat GAD1/GAD67 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2086) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit  (brown; Catalog # <a class=

Goat Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, IHC

2 Publications

Related Genes

Epilepsy, Temporal Lobe has been researched against:

Related PTMs

Epilepsy, Temporal Lobe has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Epilepsy, Temporal Lobe is also known as Psychomotor Seizure, Psychomotor Seizures, Temporal Lobe Epilepsies, Temporal Lobe Epilepsy.