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Epilepsy, Generalized: Disease Bioinformatics

Epilepsy is defined as a diverse set of neurological disorders characterized by seizures. These seizures occur due to abnormal electrical activity in the brain. Factors that may lead to epilepsy include, but are not limited to, brain trauma, gene mutations, strokes, brain cancer, and extensive drug and alcohol use. Seizures occur due to a large release of glutamate, which causes a spread of excitation throughout the brain, which propagates the electrical signal and can lead to neuronal death. Generalized epilepsy is a form of epilepsy that is defined by seizures that arise with no apparent cause. Generalized seizures are ones that affect the whole brain, and usually leads to an impairment of consciousness of the patient. Generalized epilepsy is a primary form of epilepsy, in which the seizures occur due to the epilepsy itself and not another medical condition. The GABRD gene is affected by generalized epilepsy. About 50 million people have epilepsy, with 80% of that population located in developing countries. It is possible to control epilepsy with medicine, but many cases may require surgery in order to relieve symptoms.

Epilepsy, Generalized Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Epilepsy, Generalized below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 614 products for the study of Epilepsy, Generalized that can be applied to Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.

NBP2-58876
Immunocytochemistry/Immunofluorescence: Scn1a Antibody [NBP2-58876] - Staining of human cell line ASC TERT1 shows localization to nucleoplasm & plasma membrane.

Rabbit Polyclonal
Species Human
Applications ICC/IF

NB300-190
Western Blot: GABA-A R gamma 2 Antibody [NB300-190] - Rat hippocampal (Hipp) lysate showing specific immunolabeling of the ~46 kDa gamma2-subunit of GABA A Receptor.Immunohistochemistry: GABA-A R gamma 2 Antibody [NB300-190] - Immunostaining of mouse retina showing specific labeling of the GABAA 2 subunit in green, calbindin in red and DNA in blue

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC

8 Publications
H00006326-Q01
Other Recombinant Human SCN2A Protein


Species Human

NBP1-88645
Immunohistochemistry-Paraffin: Kv7.2 Antibody [NBP1-88645] - Staining of human cerebellum shows moderate nuclear membranous positivity in Purkinje cells.

Rabbit Polyclonal
Species Human
Applications IHC, IHC-P

     1 Review

7954-GM/CF


Species Human

NBP2-42388
Western Blot: LAMC2 Antibody (CL2980) [NBP2-42388] - Analysis in human cell line A-431.Immunohistochemistry-Paraffin: LAMC2 Antibody (CL2980) [NBP2-42388] - Staining of human lymph node shows absence of immunoreactivity in lymphoid tissue (negative control).

Mouse Monoclonal
Species Human
Applications WB, IHC, IHC-P

NBP1-74102
Western Blot: Kv7.3 Antibody [NBP1-74102] - Lanes: 100 ug CHO cell lysate Primary Antibody Dilution: 1 : 1000 Secondary Antibody: Goat anti-rabbit HRP Secondary Antibody Dilution: 1 : 25000 Gene name: Kcnq3 Submitted by: Anonymous.Western Blot: Kv7.3 Antibody [NBP1-74102] - Kv7.3 Antibody Titration: 1.0 ug/ml Positive Control: Mouse Heart.

Rabbit Polyclonal
Species Mouse, Chinese Hamster
Applications WB

1 Publication
NBP1-85585
Immunocytochemistry/Immunofluorescence: CLCN2 Antibody [NBP1-85585] - Staining of human cell line CACO-2 shows localization to cytosol.Immunohistochemistry-Paraffin: CLCN2 Antibody [NBP1-85585] - Staining of human testis shows strong cytoplasmic positivity in Leydig cells.

Rabbit Polyclonal
Species Human
Applications ICC/IF, IHC, IHC-P

NBP1-51843
Western Blot: Aurora A Antibody [NBP1-51843] - WB detection of Aurora A in HeLa whole cell lysate.Immunocytochemistry/Immunofluorescence: Aurora A Antibody [NBP1-51843] - IF Confocal analysis of HeLa cells using Aurora A antibody (NBP1-51843, 1:10). An Alexa Fluor 488-conjugated Goat to rabbit IgG was used as secondary antibody (green). Actin filaments were labeled with Alexa Fluor 568 phalloidin (red). DAPI was used to stain the cell nuclei (blue).

Rabbit Polyclonal
Species Human, Mouse
Applications WB, Simple Western, ICC/IF

     1 Review

4 Publications
NB100-1533
Western Blot: POMC Antibody [NB100-1533] - Western blot analysis of POMC using NB100-1533 at 0.01ug/ml in NIH 3T3 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry-Paraffin: POMC Antibody [NB100-1533] - Analysis in human Anterior Pituitary Gland shows vesilulate staining in glandular cells.

Goat Polyclonal
Species Human, Mouse, Porcine
Applications WB, ICC/IF, IHC

6 Publications
NBP2-14040
Western Blot: GBGT1 Antibody [NBP2-14040] - Lane 1: Marker  [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.  Lane 2: Human cell line RT-4.  Lane 3: Human cell line U-251MG sp.  Lane 4: Human plasma (IgG/HSA depleted)Immunohistochemistry-Paraffin: GBGT1 Antibody [NBP2-14040] - Staining of human colon shows strong cytoplasmic positivity in glandular cells.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

NBP1-22444
Western Blot: Cav3.2 Antibody (S55-10) [NBP1-22444] - Western Blot using rat brain membranes and NBP1-22444 to target Cav3.2 channels visible at about 260kD.Immunohistochemistry: Cav3.2 Antibody (S55-10) [NBP1-22444] - Human hippocampus

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

2 Publications
NBP1-91875
Western Blot: Exostosin 1 Antibody [NBP1-91875] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).Immunohistochemistry-Paraffin: Exostosin 1 Antibody [NBP1-91875] - Staining of human rectum shows strong membranous and cytoplasmic positivity in glandular cells.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

1 Publication
AF3996
Western blot shows lysates of HCT-116 human colorectal carcinoma cell line and K562 human chronic myelogenous leukemia cell line. PVDF membrane was probed with 1 µg/mL of Human Bcl‑9 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3996) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class=

Goat Polyclonal
Species Human
Applications WB

AF1107

Goat Polyclonal
Species Mouse
Applications WB, IHC

2 Publications

Related Genes

Epilepsy, Generalized has been researched against:

Related PTMs

Epilepsy, Generalized has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Epilepsy, Generalized is also known as Epilepsies, Generalized, Generalised Epilepsy, Generalized Epilepsies, Generalized Epilepsy, Generalized Seizure Disorder.