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Down Syndrome: Disease Bioinformatics

Research of Down Syndrome has been linked to Trisomy, Cytogenetic Abnormality, Alzheimer's Disease, Congenital Abnormality, Leukemia. The study of Down Syndrome has been mentioned in research publications which can be found using our bioinformatics tool below. Researched pathways related to Down Syndrome include Pathogenesis, Aging, Meiosis, Localization, Cognition. These pathways complement our catalog of research reagents for the study of Down Syndrome including antibodies and ELISA kits against AFP, DHDDS, DHPS, PRPH2, APP.

Down Syndrome Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Down Syndrome below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 1382 products for the study of Down Syndrome that can be applied to Flow Cytometry, Western Blot, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.

MAB1368
    HepG2  human hepatocellular carcinoma cell line was stained with Mouse  Anti-Human/Mouse  alpha ‑Fetoprotein/AFP Monoclonal Antibody (Catalog #  MAB1368, filled histogram) or isotype control antibody (Catalog #  <a class=    Western  blot shows lysates of HepG2 human hepatocellular carcinoma cell line. PVDF  membrane was probed with 0.5 µg/mL of Mouse Anti-Human/Mouse<br> alpha ‑Fetoprotein/AFP Monoclonal Antibody (Catalog # MAB1368) followed  by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # <a class=

Mouse Monoclonal
Species Human, Mouse
Applications WB, Simple Western, CyTOF-ready

     6 Reviews

25 Publications
NBP1-55231
Western Blot: Dehydrodolichyl Diphosphate Synthase Antibody [NBP1-55231] - Human Placenta lysate, concentration 0.2-1 ug/ml.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB

NBP1-82648
Western Blot: DHPS Antibody [NBP1-82648] - Analysis in control (vector only transfected HEK293T lysate) and DHPS over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).Immunocytochemistry/Immunofluorescence: DHPS Antibody [NBP1-82648] - Staining of human cell line U-2 OS shows localization to nucleoplasm, plasma membrane & cytosol. Antibody staining is shown in green.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

1 Publication
NBP1-86687
Western Blot: Peripherin 2/PRPH2 Antibody [NBP1-86687] - Analysis in control (vector only transfected HEK293T lysate) and PRPH2 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).Immunohistochemistry-Paraffin: Peripherin 2/PRPH2 Antibody [NBP1-86687] - Staining of retina shows strong cytoplasmic positivity in photoreceptors.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

NBP2-13075
Immunohistochemistry: beta Amyloid Antibody (MOAB-2) [NBP2-13075] - IHC analysis of beta Amyloid on normal mouse brain (left) and 5xFAD mouse brain (right) using DAB with hematoxylin counterstain.  The MOAB-2 antibody was used at 1:20 on normal mouse brain and at 1:400 on 5xFAD mouse brain.Immunocytochemistry/Immunofluorescence: beta Amyloid Antibody (MOAB-2) [NBP2-13075] - Immunofluorescent detection of beta Amyloid with MOAB-2 in the subiculim of 1-, 2- and 4- month old 5xFAD mice.  Scale bar 20 um (from PMID: 22423893).

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, DB, ELISA

     1 Review

22 Publications
NBP2-47594
Immunocytochemistry/Immunofluorescence: TRIM26 Antibody [NBP2-47594] - Staining  human cell line A-431 shows positivity in cytoplasm and nucleus but excluded from the nucleoli.Immunohistochemistry-Paraffin: TRIM26 Antibody [NBP2-47594] - Staining of human tonsil shows strong cytoplasmic positivity in germinal center and non-germinal center cells.

Rabbit Polyclonal
Species Human
Applications ICC/IF, IHC, IHC-P

NBP1-47492
Western Blot: GATA-1 Antibody (4F5) [NBP1-47492] - Analysis using GATA1 mouse mAb against K562 (1) cell lysate.Immunocytochemistry/Immunofluorescence: GATA-1 Antibody (4F5) [NBP1-47492] - Analysis of K562(left) cells using GATA1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.

Mouse Monoclonal
Species Human, Baboon
Applications WB, ELISA, ICC/IF

     1 Review

1 Publication
NBP1-46852
Western Blot: RCAN1 Antibody [NBP1-46852] - Western blot analysis of human skeletal muscle tissue (A) using RCAN1 antibody at 2 ug/ml.Immunohistochemistry: RCAN1 Antibody [NBP1-46852] - Immunohistochemical analysis of RCAN1 in human fetal brain.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, IHC, IHC-P

H00001859-M01
Western Blot: DYRK1A Antibody (7D10) [H00001859-M01] - DYRK1A monoclonal antibody (M01), clone 7D10. Analysis of DYRK1A expression in Hela S3 NE.Western Blot: DYRK1A Antibody (7D10) [H00001859-M01] - DYRK1A monoclonal antibody (M01), clone 7D10. Western Blot analysis of DYRK1A expression in PC-12 ( Cat # L012V1 ).

Mouse Monoclonal
Species Human, Mouse
Applications WB, ELISA, IHC

51 Publications
AF1235

Goat Polyclonal
Species Human
Applications WB, IHC

1 Publication
NBP2-33903
Immunohistochemistry-Paraffin: Neurotensin Antibody [NBP2-33903] - Analysis in human small intestine and skeletal muscle tissues.  Corresponding NTS RNA-seq data are presented for the same tissues.Immunohistochemistry-Paraffin: Neurotensin Antibody [NBP2-33903] - Staining of human skeletal muscle shows no positivity in striated muscle fibers as expected.

Rabbit Polyclonal
Species Human
Applications IHC, IHC-P

NBP1-85740
Western Blot: 5'-Nucleotidase/CD73 Antibody [NBP1-85740] - Analysis in human cell line U-87 MG.Immunocytochemistry/Immunofluorescence: 5'-Nucleotidase/CD73 Antibody [NBP1-85740] - Staining for human aortic valve endothelial cells. Image from a verified customer review.

Rabbit Polyclonal
Species Human, Porcine
Applications WB, ICC/IF, IHC

     4 Reviews

8 Publications
NBP2-24915
Western Blot: SOD1/Cu-Zn SOD Antibody [NBP2-24915] - Analysis of SOD in liver lysate of 1) human, 2) mouse, and 3) rat using this antibody. 025 ug/ml.Immunohistochemistry-Paraffin: SOD1/Cu-Zn SOD Antibody [NBP2-24915] - Analysis of Superoxide Dismutase 1 in FFPE human liver tissue using an isotype control (top) and NBP2-24915 (bottom) at 5 ug/ml.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC-P

     1 Review

7 Publications
NBP2-30716
Immunocytochemistry/Immunofluorescence: DSCAM Antibody [NBP2-30716] - Staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.Immunohistochemistry-Paraffin: DSCAM Antibody [NBP2-30716] - Staining of human skeletal muscle shows no positivity in myocytes as expected.

Rabbit Polyclonal
Species Human
Applications ICC/IF, IHC, IHC-P

NB100-82245
Western Blot: Tau [p Thr181] Antibody [NB100-82245] - Analysis of extracts from mouse brain tissue using Tau(Phospho-Thr181) Antibody and the same antibody preincubated with blocking peptide.Immunohistochemistry-Paraffin: Tau [p Thr181] Antibody [NB100-82245] - analysis of paraffin-embedded rat hippocampal region tissue from a model with Alzheimer's Disease using Tau (phospho-Thr181) antibody.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, IHC

     1 Review

1 Publication
NB100-74510
Western Blot: Presenilin-1 Antibody (APS 18) [NB100-74510] - Analysis of THP-1 cell lysate.Immunocytochemistry/Immunofluorescence: Presenilin-1 Antibody (APS 18) [NB100-74510] - Analysis of Presenilin 1 using Presenilin 1 Monoclonal antibody (APS 18) shows staining in A2058 melanoma cells. Presenilin 1 staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing Presenilin 1 at a dilution of 1:20-1:100 over night at 4C, washed with PBS and incubated with a DyLight-488 conjugated.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, ICC/IF

4 Publications
NB110-60531
Immunohistochemistry-Paraffin: Apolipoprotein E/ApoE Antibody (WUE-4) [NB110-60531] - ApoE was detected in immersion fixed paraffin-embedded sections of human liver using anti-human mouse monoclonal antibody (Catalog # NB110-60531) at 1:200 dilution overnight at 4C. Tissue was stained using the VisuCyte anti-mouse HRP polymer detection reagent (Catalog # VC001) with DAB chromogen (brown) and counterstained with hematoxylin (blue). Images may not be copied, printed or otherwise disseminated without express written permission of Novus Biologicals a bio-techne brand.Western Blot: Apolipoprotein E/ApoE Antibody (WUE-4) [NB110-60531] - ApoE Antibody (WUE-4) [NB110-60531] - Detection of ApoE in human tissue lysate using NB110-60531. Lane 1: liver Lane 2: brain

Mouse Monoclonal
Species Human, Mouse, Rat (Negative)
Applications WB, ELISA, Flow

     2 Reviews

16 Publications
NBP2-37607
Western Blot: MTHFR Antibody (5D3) [NBP2-37607] - Western blot analysis using MTHFR mouse mAb against Rat Heart cell lysate.Immunohistochemistry-Paraffin: MTHFR Antibody (5D3) [NBP2-37607] -  Analysis of  intima cancer tissues (left) and prostate tissues (right) using MTHFR mouse mAb with DAB staining.

Mouse Monoclonal
Species Human, Rat
Applications WB, ELISA, IHC


Alternate Names

Down Syndrome is also known as down syndrome, trisomy 21, 47,xy,+21, 47,xx,+21, complete trisomy 21 syndrome (disorder), down's syndrome nos (disorder), down's syndrome - trisomy 21, trisomy 21 syndrome, down's syndrome nos, down's syndrome, downs syndrome, g trisomy, trisomy g, trisomy.