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Dementia Of The Alzheimer's Type, With Early Onset, Uncomplicated: Disease Bioinformatics

Alzheimer's Disease (AD) is a neurological disease that is the most common cause of dementia. Early onset of the disease occurs in patients under the age of 65, which is approximately 5-10% of all diagnosed cases of Alzheimer's. Dementia of the Alzheimer’s type is a degenerative process of cells in the forebrain whose function is to send information to the cerebral cortex and hippocampus. Uncomplicated means the patient does not suffer from delirium, delusions, or a depressed mood. The disease leads to memory loss, and in the later stages, an inability to perform daily activities. There is currently no cure for Alzheimer’s, but there exist treatments for symptoms as well as a multitude of ongoing research projects.

Dementia Of The Alzheimer's Type, With Early Onset, Uncomplicated Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Dementia Of The Alzheimer's Type, With Early Onset, Uncomplicated below! For more information on how to use Laverne, please read the How to Guide.
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Top Research Reagents

We have 718 products for the study of Dementia Of The Alzheimer's Type, With Early Onset, Uncomplicated that can be applied to Western Blot, Immunocytochemistry/Immunofluorescence, Flow Cytometry, Immunohistochemistry from our catalog of antibodies and ELISA kits.

NB100-74510
Western Blot: Presenilin-1 Antibody (APS 18) [NB100-74510] - Analysis of THP-1 cell lysate.Immunocytochemistry/Immunofluorescence: Presenilin-1 Antibody (APS 18) [NB100-74510] - Analysis of Presenilin 1 using Presenilin 1 Monoclonal antibody (APS 18) shows staining in A2058 melanoma cells. Presenilin 1 staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing Presenilin 1 at a dilution of 1:20-1:100 over night at 4C, washed with PBS and incubated with a DyLight-488 conjugated.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, ICC/IF

     1 Review

4 Publications
NB100-74513
Western Blot: Presenilin-2 Antibody (APS 26) [NB100-74513] - Analysis of 25 ug of human brain (lane 1) and L929 (lane 2) onto an SDS polyacrylamide gel.Immunocytochemistry/Immunofluorescence: Presenilin-2 Antibody (APS 26) [NB100-74513] - Presenilin 2 staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing Presenilin 2 at a dilution of 1:20 over night at 4C, washed with PBS and incubated with a DyLight-488 conjugated.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, ICC/IF

NB110-60531
Immunohistochemistry-Paraffin: Apolipoprotein E/ApoE Antibody (WUE-4) [NB110-60531] - ApoE was detected in immersion fixed paraffin-embedded sections of human liver using anti-human mouse monoclonal antibody (Catalog # NB110-60531) at 1:200 dilution overnight at 4C. Tissue was stained using the VisuCyte anti-mouse HRP polymer detection reagent (Catalog # VC001) with DAB chromogen (brown) and counterstained with hematoxylin (blue). Images may not be copied, printed or otherwise disseminated without express written permission of Novus Biologicals a bio-techne brand.Western Blot: Apolipoprotein E/ApoE Antibody (WUE-4) [NB110-60531] - ApoE Antibody (WUE-4) [NB110-60531] - Detection of ApoE in human tissue lysate using NB110-60531. Lane 1: liver Lane 2: brain

Mouse Monoclonal
Species Human, Mouse, Rat (Negative)
Applications WB, ELISA, Flow

     2 Reviews

18 Publications
NBP2-42388
Western Blot: LAMC2 Antibody (CL2980) [NBP2-42388] - Analysis in A-431 cells transfected with control siRNA, target specific siRNA probe #1 and #2, using Anti-LAMC2 antibody. Remaining relative intensity is presented. Loading control: Anti-GAPDH.Immunocytochemistry/Immunofluorescence: LAMC2 Antibody (CL2980) [NBP2-42388] - Staining of A-431 cells using the Anti-LAMC2 monoclonal antibody, showing specific staining in the cytosol in green. Microtubule- and nuclear probes are visualized in red and blue, respectively (where available).

Mouse Monoclonal
Species Human
Applications WB, ICC/IF, IHC

2 Publications
NBP2-13075
Immunohistochemistry: beta Amyloid Antibody (MOAB-2) [NBP2-13075] - IHC analysis of beta Amyloid on normal mouse brain (left) and 5xFAD mouse brain (right) using DAB with hematoxylin counterstain.  The MOAB-2 antibody was used at 1:20 on normal mouse brain and at 1:400 on 5xFAD mouse brain.Immunocytochemistry/Immunofluorescence: beta Amyloid Antibody (MOAB-2) [NBP2-13075] - Immunofluorescent detection of beta Amyloid with MOAB-2 in the subiculim of 1-, 2- and 4- month old 5xFAD mice.  Scale bar 20 um (from PMID: 22423893).

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, DB, ELISA

     2 Reviews

25 Publications
NBP2-22164
Western Blot: SLC6A3/DAT1 Antibody (mAb16) [NBP2-22164] - Western blot analysis of DAT protein. Band shown at approx. 75 kDa. Image submitted by verified customer review. Immunocytochemistry/Immunofluorescence: DAT1 Antibody (mAb16) [NBP2-22164] - The DAT1 antibody was tested in PC12 cells at a 1:250 dilution against DyLight 488 (Green). Actin and nuclei were counterstained with Phalloidin-AlexaFluor 568 (Red) and DAPI (Blue), respectively.

Mouse Monoclonal
Species Mouse, Rat, Human (Negative)
Applications WB, ELISA, ICC/IF

     3 Reviews

12 Publications
AF9024
  Western  blot shows lysates of mouse heart tissue and mouse liver tissue. PVDF  membrane was probed with 1 µg/mL of Goat Anti-Mouse/Rat  Butyrylcholinesterase/BCHE Polyclonal Antibody (Catalog # AF9024) followed by  HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class=  Butyrylcholinesterase/BCHE  was detected in perfusion fixed frozen sections of mouse brain using Goat  Anti-Mouse/Rat Butyrylcholinesterase/BCHE Antigen Affinity-purified  Polyclonal Antibody <br>(Catalog # AF9024) at 5 µg/mL  overnight at 4 °C. Tissue was stained using the Anti-Goat  HRP-DAB Cell & Tissue Staining Kit   (brown; Catalog # <a class=

Goat Polyclonal
Species Mouse, Rat
Applications WB, IHC

7954-GM/CF


Species Human

1 Publication
NBP1-89946
Immunocytochemistry/Immunofluorescence: Dystonin Antibody [NBP1-89946] - Staining of human cell line A-431 shows localization to nucleus & cytosol. Antibody staining is shown in green.Immunohistochemistry-Paraffin: Dystonin Antibody [NBP1-89946] - Staining of human tonsil shows low positivity in non-germinal center cells as expected.

Rabbit Polyclonal
Species Human
Applications ICC/IF, IHC, IHC-P

7570-GH


Species Human

7 Publications
NBP1-89036
Western Blot: APLP-1 Antibody [NBP1-89036] - Analysis in control (vector only transfected HEK293T lysate) and APLP1 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).Immunohistochemistry-Paraffin: APLP-1 Antibody [NBP1-89036] - Staining of human liver shows no positivity in hepatocytes as expected.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P


Related Genes

Dementia Of The Alzheimer's Type, With Early Onset, Uncomplicated has been researched against:

Related Pathways

Dementia Of The Alzheimer's Type, With Early Onset, Uncomplicated has been linked to:

Alternate Names

Dementia Of The Alzheimer's Type, With Early Onset, Uncomplicated is also known as Alzheimer's Disease With Early Onset, Dementia In Alzheimer's Disease With Early Onset.