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Cornelia De Lange Syndrome: Disease Bioinformatics

Research of Cornelia De Lange Syndrome has been linked to Congenital Abnormality, Cytogenetic Abnormality, Growth Retardation, Microcephaly, Trisomy. The study of Cornelia De Lange Syndrome has been mentioned in research publications which can be found using our bioinformatics tool below. Researched pathways related to Cornelia De Lange Syndrome include Sister Chromatid Cohesion, Chromosome Segregation, Dna Repair, Pathogenesis, Interphase. These pathways complement our catalog of research reagents for the study of Cornelia De Lange Syndrome including antibodies and ELISA kits against NIPBL, SMC1A, SMC3, RAD21, ESCO2.

Cornelia De Lange Syndrome Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Cornelia De Lange Syndrome below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 789 products for the study of Cornelia De Lange Syndrome that can be applied to Chromatin Immunoprecipitation, Chromatin Immunoprecipitation (ChIP), Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

NB600-302
Western Blot: c-Myc Antibody (9E10) [NB600-302] - CtIP is phosphorylated by CDKs at multiple sites. Myc-BRCA1 and/or HA-CtIP WT or indicated mutants were expressed in 293T cells and co-immunoprecipitation was performed. Image collected and cropped by CiteAb from the following publication (//doi.org/10.1371/journal.pgen.1003277) licensed under a CC-BY licence.Immunohistochemistry-Paraffin: c-Myc Antibody (9E10) [NB600-302] - c-Myc was detected in immersion fixed paraffin-embedded sections of human breast cancer using anti-human mouse monoclonal antibody (Catalog # NB600-302, clone 9E10) at 1:50 dilution overnight at 4 C. Tissue was stained using the VisuCyte anti-mouse HRP polymer detection reagent (Catalog # VC001) with DAB chromogen (brown) and counterstained with hematoxylin (blue). <br/>Images may not be copied, printed or otherwise disseminated without express written permission of Novus Biologicals a bio-techne brand.

Mouse Monoclonal
Species Human, Mouse, Bovine
Applications WB, Simple Western, ChIP

     4 Reviews

35 Publications
NB100-204
Immunohistochemistry-Paraffin: SMC1 Antibody [NB100-204] - FFPE section of mouse colon carcinoma CT26. Antibody: Affinity purified rabbit anti-SMC1 used at a dilution of 1:5,000 (0.2ug/ml). Detection: DABImmunohistochemistry-Paraffin: SMC1 Antibody [NB100-204] -  FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-SMC1 used at a dilution of 1:5,000 (0.2ug/ml). Detection: DAB

Rabbit Polyclonal
Species Human, Mouse
Applications WB, Simple Western, ELISA

34 Publications
H00010735-M01
Western Blot: STAG2 Antibody (3C6) [H00010735-M01] - STAG2 monoclonal antibody (M01), clone 3C6 Analysis of STAG2 expression in Hela S3 NE.Immunocytochemistry/Immunofluorescence: STAG2 Antibody (3C6) [H00010735-M01] - Analysis of monoclonal antibody to STAG2 on HeLa cell. Antibody concentration 10 ug/ml.

Mouse Monoclonal
Species Human, Mouse
Applications WB, ELISA, ICC/IF

     1 Review

1 Publication
NBP1-30052
Western Blot: Choline Acetyltransferase/ChAT Antibody [NBP1-30052] - Rat brain lysate showing specific immunolabeling of the ~70k ChAT.Immunocytochemistry/Immunofluorescence: Choline Acetyltransferase/ChAT Antibody [NBP1-30052] - Representative images of lumbar spinal cord sections at 130 days immunostained with Choline Acetyltransferase/ChAT. Scale bar, 200 um. Image collected and cropped by CiteAb from the following publication (http://embomolmed.embopress.org/lookup/doi/10.15252/emmm.201808888), licensed under a CC-BY licence.

Goat Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

17 Publications
NBP1-52168
Immunocytochemistry/Immunofluorescence: NIPBL Antibody [NBP1-52168] - analysis of paraformaldehyde fixed HeLa cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (4ug/ml), showing nuclear and cytoplasmic staining. The nuclear staiImmunohistochemistry-Paraffin: NIPBL Antibody [NBP1-52168] - (2ug/ml) staining of paraffin embedded Human Kidney. Microwaved antigen retrieval with citrate buffer pH 6, HRP-staining.

Goat Polyclonal
Species Human
Applications ICC/IF, IHC, IHC-P

1 Publication
NB100-87021
Western Blot: ESCO2 Antibody [NB100-87021] - Detection of Human ESCO2 by Western Blot. Samples: Whole cell lysate (50, 15, 5 ug) from HeLa cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-ESCO2 antibody NB100-87021 used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.Immunoprecipitation: ESCO2 Antibody [NB100-87021] - Detection of human ESCO2 by western blot of immunoprecipitates. Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from HeLa cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-ESCO2 antibody NB100-87021 (lot 2) used for IP at 6 ug per reaction. ESCO2 was also immunoprecipitated by a previous lot of this antibody (lot 1) and rabbit anti-ESCO2 antibody from Company B. For blotting immunoprecipitated ESCO2, NB100-87021 was used at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

Rabbit Polyclonal
Species Human
Applications WB, IP

4 Publications
NBP1-87097
Western Blot: SA1 Antibody [NBP1-87097] - Analysis in U-138MG cells transfected with control siRNA, target specific siRNA probe #1 and #2,. Remaining relative intensity is presented. Loading control: Anti-GAPDH.Immunocytochemistry/Immunofluorescence: SA1 Antibody [NBP1-87097] - Staining of human cell line A-431 shows localization to nucleus & nuclear bodies. Antibody staining is shown in green.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

NBP1-87904
Immunohistochemistry-Paraffin: SCC112 Antibody [NBP1-87904] - Staining of human cerebral cortex, colon, kidney and lymph node using Anti-PDS5A antibody NBP1-87904 (A) shows similar protein distribution across tissues to independent antibody NBP2-38313 (B).Western Blot: SCC112 Antibody [NBP1-87904] - Analysis using Anti-PDS5A antibody NBP1-87904 (A) shows similar pattern to independent antibody NBP2-38313 (B).

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

NBP2-13306
Western Blot: SH2D3C Antibody [NBP2-13306] - Lane 1: Marker  [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.  Lane 2: Human cell line RT-4.  Lane 3: Human cell line U-251MG spImmunohistochemistry-Paraffin: SH2D3C Antibody [NBP2-13306] - Staining in human spleen and pancreas tissues using anti-SH2D3C antibody. Corresponding SH2D3C RNA-seq data are presented for the same tissues.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

NBP2-20053
Western Blot: Rad21 Antibody [NBP2-20053] - A: NIH-3T3  B: JC   C: BCL-1  7.5% SDS PAGE   diluted at 1:3000 The HRP-conjugated anti-rabbit IgG antibody (NBP2-19301) was used to detect the primary antibody.Immunocytochemistry/Immunofluorescence: Rad21 Antibody [NBP2-20053] -  HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: Rad21 stained by Rad21 antibody diluted at 1:1000. Red: phalloidin, a cytoskeleton marker, diluted at 1:100.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

     1 Review

NB100-755
Western Blot: APRIN Antibody [NB100-755] - Whole cell lysate (50 ug) from HeLa, 293T, Jurkat, mouse TCMK-1, and mouse NIH3T3 cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit antiPds5b antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 secondsImmunohistochemistry-Paraffin: APRIN Antibody [NB100-755] -  Section of human lung small cell carcinoma. Antibody: Affinity purified rabbit anti- Pds5B  used at a dilution of 1:200 (1ug/ml). Detection: DAB

Rabbit Polyclonal
Species Human, Mouse
Applications WB, IHC, IHC-P

4 Publications
AF4928
K562 human chronic myelogenous leukemia cell line was stained with Goat Anti-Human ERMAP Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4928, filled histogram) or control antibody (Catalog # <A class=NoLineLink href=

Goat Polyclonal
Species Human
Applications WB, Flow, CyTOF-ready

DPPA00
 Pappalysin-1/PAPP-A [HRP] Pappalysin-1/PAPP-A [HRP]


Species Human
Applications ELISA

4 Publications
292-G2
1 μg/lane of Recombinant Human IGF‑II/IGF2 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 7 kDa.Recombinant Human IGF-II/IGF2 (Catalog # 292‑G2) stimulates cell proliferation in the MCF-7 human breast cancer cell line. The ED<sub>50</sub> for this effect is 1.5‑6 ng/mL.


Species Human
Applications BA

     1 Review

40 Publications
NBP2-67001
Western Blot: CTCF Antibody (JM10-61) [NBP2-67001] - Western blot analysis of CTCF on zebrafish tissue lysates. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in PBS for 1 hour at room temperature. The primary antibody (1/500) was used in 5% BSA at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1:5,000 dilution was used for 1 hour at room temperature.Immunocytochemistry/Immunofluorescence: CTCF Antibody (JM10-61) [NBP2-67001] - Staining CTCF in NIH-3T3 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Rabbit Monoclonal
Species Human, Mouse, Rat
Applications WB, Flow, ICC/IF

H00023383-P01
12.5% SDS-PAGE Stained with Coomassie Blue.


Species Human
Applications WB, ELISA, PA

NB100-207
Western Blot: SMC3 Antibody [NB100-207] - Whole cell lysate (10 ug) from HEK293T, HeLa, Jurkat, LNCaP, U2OS, A-549, TCMK-1, and NIH 3T3 cells prepared using NETN lysis buffer. Antibody: Affinitypurified rabbit anti-SMC3 antibody  used for WB at 0.04 ug/ml. Detection:Chemiluminescence with an exposure time of 3 seconds.Immunohistochemistry-Paraffin: SMC3 Antibody [NB100-207] -  Section of mouse renal cell carcinoma. Antibody: Affinity purified rabbit anti-SMC3  used at 1:5,000 (0.2ug/ml). Detection: DAB

Rabbit Polyclonal
Species Human, Mouse, C. elegans
Applications WB, IHC, IHC-P

8 Publications

Related Genes

Cornelia De Lange Syndrome has been researched against:

Related PTMs

Cornelia De Lange Syndrome has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Cornelia De Lange Syndrome is also known as cornelia de lange syndrome, de lange syndrome, brachmann de lange syndrome, typus degenerativus amstelodamensis, de lange syndrome (disorder), des syndrome.