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Congenital Anomaly Of Brain: Disease Bioinformatics

There are a large number of congenital anomalies that involve the cranium and the brain and occur as a result of disorders that are present before or at birth. The anomalies stem from developmental issues of the nervous system, and they typically lead to debilitating disorders as well as death in some cases. There is not a single factor which causes brain and cranium anomalies, but can be the effect of genetic conditions, medicines taken during pregnancy, maternal infection, or radiation. An example of congenital brain and cranium anomalies includes anencephaly, where the cephalic end of the neural tube doesn’t close, which results in the baby being born without a forebrain and is blind, deaf and unconsciousness, and has a very small chance of ever waking up. Other common congenital brain and cranium anomalies are colpocephaly, holoprosencephaly, hydranencephaly, iniencephaly, lissencephaly, megalencephaly, microcephaly, porencephaly and schizencephaly.

Congenital Anomaly Of Brain Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Congenital Anomaly Of Brain below! For more information on how to use Laverne, please read the How to Guide.
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Top Research Reagents

We have 493 products for the study of Congenital Anomaly Of Brain that can be applied to Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

H00002316-M01
Western Blot: Filamin A Antibody (4E10-1B2) [H00002316-M01] - FLNA monoclonal antibody (M01), clone 4E10-1B2 Analysis of FLNA expression in HL-60.Immunohistochemistry-Paraffin: Filamin A Antibody (4E10-1B2) [H00002316-M01] - Analysis of monoclonal antibody to FLNA on formalin-fixed paraffin-embedded human lymphoma tissue. Antibody concentration 1.5 ug/ml.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, ICC/IF

11 Publications
NBP1-33383
Western Blot: FKTN Antibody [NBP1-33383] - Sample (30 ug of whole cell lysate) A: H1299 B: Hela 10% SDS PAGE; antibody diluted at 1:1000.Immunocytochemistry/Immunofluorescence: FKTN Antibody [NBP1-33383] - Methanol-fixed HeLa, using FKTN antibody at 1:200 dilution.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF

NB600-1081
Immunohistochemistry-Frozen: Reelin Antibody (G10) [NB600-1081] - Frozen mouse brain coronal section stained with Reelin Antibody (G10). IHC-Fr image submitted by a verified customer review.Immunohistochemistry: Reelin Antibody (G10) [NB600-1081] - Mouse anti-Reelin staining of embryonic cerebral cortex at 15 days in utero, with the pial surface above and the ventricle below. The positive zone is the Cajal-Retzius cell layer in the marginal zone, positive for reelin using NB600-1081.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

12 Publications
NBP1-72042
Western Blot: Doublecortin Antibody [NBP1-72042] - staining of Mouse fetal Brain lysate (35 ug protein in RIPA buffer). Antibody at 0.01 ug/mL. Primary incubation was 1 hour. Detected by chemiluminescence.Immunocytochemistry/Immunofluorescence: Doublecortin Antibody [NBP1-72042] - Immunofluorescence analysis of paraformaldehyde fixed KNRK cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (2 ug/mL), showing cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (2 ug/mL).

Goat Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

2 Publications
H00006496-M04
Western Blot: Six3 Antibody (1A2) [H00006496-M04] - Analysis of SIX3 expression in FHs 173 WE.Western Blot: Six3 Antibody (1A2) [H00006496-M04] - Analysis of SIX3 expression in 293 (Cat # L026V1).

Mouse Monoclonal
Species Human
Applications WB, ELISA

NBP1-86152
Western Blot: POMT2 Antibody [NBP1-86152] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells). Lane 2: NBT-II cell lysate (Rat Wistar bladder tumor cells).Immunohistochemistry-Paraffin: POMT2 Antibody [NBP1-86152] - Staining of human prostate shows strong granular cytoplasmic positivity in glandular cells.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC, IHC-P

NBP1-87769
Immunohistochemistry-Paraffin: LIS1 Antibody [NBP1-87769] - Analysis in human testis and liver tissues using NBP1-87769 antibody. Corresponding PAFAH1B1 RNA-seq data are presented for the same tissues.Western Blot: LIS1 Antibody [NBP1-87769] - Analysis of LIS1 in caco-2 whole cell lysate using anti-LIS1 antibody.  Image submitted by a verified customer review.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

     2 Reviews

NBP2-03688
Western Blot: SAE2 Antibody (4A3) [NBP2-03688] Analysis of extracts (35ug) from 9 different cell lines by using anti-SAE2 monoclonal antibody.Immunocytochemistry/Immunofluorescence: SAE2 Antibody (4A3) [NBP2-03688] - Staining of COS7 cells transiently transfected by pCMV6-ENTRY SAE2.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

NBP2-14868
Western Blot: Dystroglycan Antibody [NBP2-14868] - Various tissue extracts (30 ug) were separated by 7.5% SDS-PAGE, and the membrane was blotted with Dystroglycan Antibody diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (NBP2-19301) was used to detect the primary antibody.Immunocytochemistry/Immunofluorescence: Dystroglycan Antibody [NBP2-14868] - HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: Dystroglycan protein stained by Dystroglycan antibody 38) diluted at 1:1000. Red: alpha Tubulin, a cytoskeleton marker, stained by alpha Tubulin antibody [B-5-1-2]  diluted at 1:10000. Blue: Hoechst 33342 staining.

Rabbit Polyclonal
Species Human, Mouse, Equine
Applications WB, ICC/IF, IHC

2 Publications
NBP2-24607
Western Blot: Zic2 Antibody [NBP2-24607] - Analysis of ZIC2 in HepG2 cell lysate using 1) pre-bleed, and 2) this antibody.  Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

Rabbit Polyclonal
Species Human, Mouse, Bovine
Applications WB

AF4634
Western blot shows lysates of human brain (cortex) tissue and human brain (hippocampus) tissue. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human GPR56 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4634) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # <A class=NoLineLink href=    Simple  Western lane view shows lysates of human brain (motor cortex) tissue and  SK‑BR‑3 human breast cancer cell line, loaded at  0.2 mg/mL. A specific band was detected for GPR56 at approximately  116 kDa (as indicated) using 10 µg/mL of Sheep Anti-Human  GPR56 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4634)  followed by 1:50 dilution of HRP-conjugated Anti-Sheep IgG Secondary Antibody  (Catalog # <a class=

Sheep Polyclonal
Species Human
Applications WB, Simple Western, Flow

     1 Review

2 Publications
AF7068
Western blot shows lysates of U‑87 MG human glioblastoma/astrocytoma cell line, U‑118‑MG human glioblastoma/astrocytoma cell line, and human brain (cortex) tissue. PVDF membrane was probed with 2 µg/mL of Sheep Anti-Human ARX Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7068) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # <A class=NoLineLink href=ARX was detected in immersion fixed U‑87 MG human glioblastoma/astrocytoma cell line using Sheep Anti-Human ARX Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7068) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Sheep IgG Secondary Antibody (red, upper panel; Catalog # <a class=

Sheep Polyclonal
Species Human
Applications WB, IHC, ICC

2 Publications
DPLG70
 PLA2G7/PAF-AH/Lp-PLA2 [HRP] PLA2G7/PAF-AH/Lp-PLA2 [HRP]


Species Human
Applications ELISA

     1 Review

13 Publications
464-SH/CF
Recombinant Mouse Sonic Hedgehog/Shh (C25Il), N-Terminus (Catalog # 464-SH/CF) induces alkaline phosphatase production by the C3H10T1/2 mouse embryonic fibroblast cell line. The activity is more than 30-fold greater than the top competitor's Sonic Hedgehog.1 μg/lane of Recombinant Mouse Sonic Hedgehog/Shh (C25Il), N-Terminus was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 22 kDa.


Species Mouse
Applications BA

44 Publications
NBP2-46109
Western Blot: TGIF1 Antibody (1B12) [NBP2-46109] - Analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TGIF1 .Immunohistochemistry: TGIF1 Antibody (1B12) [NBP2-46109] - Analysis of Human tonsil tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min)

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, IHC, IHC-P

NB110-41404
Western Blot: Glutamine Synthetase Antibody [NB110-41404] - Analysis of glutamine synthase. 40ug of lysates from mouse (Lanes M), rat (Lane R), pig (Lane P), bovine (Lane B), or human (Lane Hu) retina were probed. A 42 kDa band was identified in lysates from retinas of all species.Immunocytochemistry/Immunofluorescence: Glutamine Synthetase Antibody [NB110-41404] - Immunofluorescence using NB110-41404. Submitted via verified customer review.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

     1 Review

6 Publications
NBP3-04945
Western Blot: FKRP Antibody [NBP3-04945] - Analysis of extracts of various cell lines, using FKRP antibody at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC, IHC-P

NBP2-93413
Western Blot: POMT1 Antibody [NBP2-93413] - Analysis of extracts of various cell lines, using POMT1 at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit . Exposure time: 5s.

Rabbit Polyclonal
Species Human, Mouse
Applications WB

NBP2-93561
Western Blot: POMGNT1 Antibody [NBP2-93561] - Analysis of extracts of various cell lines, using POMGNT1 at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit . Exposure time: 60s.Immunohistochemistry-Paraffin: POMGNT1 Antibody [NBP2-93561] - Paraffin-embedded human prostate using POMGNT1 .

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC, IHC-P


Related Genes

Congenital Anomaly Of Brain has been researched against:

Related PTMs

Congenital Anomaly Of Brain has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Congenital Anomaly Of Brain is also known as Brain Malformation, Brain Malformations, Congenital Brain Anomaly, Deformity Of Brain.