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Congenital Anomaly Of Brain: Disease Bioinformatics

There are a large number of congenital anomalies that involve the cranium and the brain and occur as a result of disorders that are present before or at birth. The anomalies stem from developmental issues of the nervous system, and they typically lead to debilitating disorders as well as death in some cases. There is not a single factor which causes brain and cranium anomalies, but can be the effect of genetic conditions, medicines taken during pregnancy, maternal infection, or radiation. An example of congenital brain and cranium anomalies includes anencephaly, where the cephalic end of the neural tube doesn’t close, which results in the baby being born without a forebrain and is blind, deaf and unconsciousness, and has a very small chance of ever waking up. Other common congenital brain and cranium anomalies are colpocephaly, holoprosencephaly, hydranencephaly, iniencephaly, lissencephaly, megalencephaly, microcephaly, porencephaly and schizencephaly.

Congenital Anomaly Of Brain Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Congenital Anomaly Of Brain below! For more information on how to use Laverne, please read the How to Guide.
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Top Research Reagents

We have 415 products for the study of Congenital Anomaly Of Brain that can be applied to Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.

NBP1-87769
Western Blot: LIS1 Antibody [NBP1-87769] - Lane 1: Marker  [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.  Lane 2: Human cell line RT-4.  Lane 3: Human cell line U-251MG spImmunocytochemistry/Immunofluorescence: LIS1 Antibody [NBP1-87769] - Immunofluorescent staining of human cell line U-251 MG shows localization to centrosome.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

     2 Reviews

NBP1-33383
Western Blot: FKTN Antibody [NBP1-33383] - Sample (30 ug of whole cell lysate) A: H1299 B: Hela 10% SDS PAGE; antibody diluted at 1:1000.Immunocytochemistry/Immunofluorescence: FKTN Antibody [NBP1-33383] - Methanol-fixed HeLa, using FKTN antibody at 1:200 dilution.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF

7414-GT


Species Human

1 Publication
1845-SH
1 μg/lane of Recombinant Human Sonic Hedgehog/Shh (C24II), N-Terminus was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 22 kDa.MALDI-TOF analysis of Recombinant Human Sonic Hedgehog/Shh (C24II), N-Terminus. The major peak corresponds to the calculated molecular mass, 19814 Da. The minor peak at 20029  is a matrix-associated artifact of the MALDI-TOF.


Species Human

     5 Reviews

29 Publications
NBP1-92684
Western Blot: Doublecortin Antibody (3E1) [NBP1-92684] - Analysis of rat whole brain lysates using mouse mAb to Doublecortin (DCX), NBP1-92684, dilution 1:1,000 in green: [1] protein standard (red), [2] adult rat brain, [3] embryonic E20 rat brain. Strong bands at 40, 45kDa correspond to DCX protein, detected only in the developing brain.Immunocytochemistry/Immunofluorescence: Doublecortin Antibody (3E1) [NBP1-92684] - Analysis of cortical neuron-glial cell culture from E20 rat stained with mouse mAb to Doublecortin (DCX), NBP1-92684, dilution 1:1,000 in red, and costained with chicken pAb to Microtubule Associated Protein2 (MAP2), dilution 1:10,000 in green. The blue is DAPI staining of nuclear DNA. DCX antibody reveals strong cytoplasmic staining in a population of small developing neurons and their processes, while MAP2 antibody stains dendrites and perikarya of mature neurons. Therefore DCX antibody is an excellent marker of developing neuronal cells.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

AF7068
Western blot shows lysates of U‑87 MG human glioblastoma/astrocytoma cell line, U‑118‑MG human glioblastoma/astrocytoma cell line, and human brain (cortex) tissue. PVDF membrane was probed with 2 µg/mL of Sheep Anti-Human ARX Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7068) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # <A class=NoLineLink href=ARX was detected in immersion fixed U‑87 MG human glioblastoma/astrocytoma cell line using Sheep Anti-Human ARX Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7068) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Sheep IgG Secondary Antibody (red, upper panel; Catalog # <a class=

Sheep Polyclonal
Species Human
Applications WB, IHC, ICC

NBP2-14868
Western Blot: Alpha Dystroglycan Antibody [NBP2-14868] -  U87-MG whole cell extracts and membrane extracts (30 ug) were separated by 7.5% SDS-PAGE, and the membrane was blotted with DAG1 antibody diluted at 1:500.Immunocytochemistry/Immunofluorescence: Alpha Dystroglycan Antibody [NBP2-14868] - HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: alpha Dystroglycan protein stained by alpha Dystroglycan antibody 38) diluted at 1:1000. Red: alpha Tubulin, a cytoskeleton marker, stained by alpha Tubulin antibody [B-5-1-2]  diluted at 1:10000. Blue: Hoechst 33342 staining.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

1 Publication
NBP2-57200
Immunocytochemistry/Immunofluorescence: POMT1 Antibody [NBP2-57200] - Staining of human cell line MCF7 shows localization to the Golgi apparatus. Antibody staining is shown in green.

Rabbit Polyclonal
Species Human
Applications ICC/IF

NB120-22104
Western Blot: SAE2 Antibody [NB120-22104] - Western bot analysis of SAE2 in HeLa cell lysate using NB120-22104 at 1.0 ug/ml.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB

4 Publications
NB600-1081
Immunohistochemistry: Reelin Antibody (G10) [NB600-1081] - Mouse anti-Reelin. Immunolocalization of Reelin (red) in the cortex of e14.5 mouse CNS. The blue stain is Hoechst nuclear counter stain. Photo courtesy of Dr. Jason Emsley, Harvard Medical School, Boston, MA.Immunohistochemistry: Reelin Antibody (G10) [NB600-1081] - Mouse anti-Reelin staining of embryonic cerebral cortex at 15 days in utero, with the pial surface above and the ventricle below. The positive zone is the Cajal-Retzius cell layer in the marginal zone, positive for reelin using NB600-1081.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, IHC, IHC-P

11 Publications
H00002316-M01
Western Blot: Filamin A Antibody (4E10-1B2) [H00002316-M01] - FLNA monoclonal antibody (M01), clone 4E10-1B2 Analysis of FLNA expression in HL-60.Immunohistochemistry-Paraffin: Filamin A Antibody (4E10-1B2) [H00002316-M01] - Analysis of monoclonal antibody to FLNA on formalin-fixed paraffin-embedded human lymphoma tissue. Antibody concentration 1.5 ug/ml.

Mouse Monoclonal
Species Human
Applications WB, ELISA, IHC-P

11 Publications
MAB7555
Western blot shows lysates of HCT‑116 human colorectal carcinoma cell line, JAR human choriocarcinoma cell line, and A549 human lung carcinoma cell line. PVDF membrane was probed with 0.1 µg/mL of Mouse Anti-Human TGIF1 Monoclonal Antibody (Catalog # MAB7555) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # <A class=NoLineLink href=Simple Western lane view shows lysates of HCT‑116 human colorectal carcinoma cell line, loaded at 0.5 mg/mL. A specific band was detected for TGIF1 at approximately 38 kDa (as indicated) using 1 µg/mL of Mouse Anti-Human TGIF1 Monoclonal Antibody (Catalog # MAB7555). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.

Mouse Monoclonal
Species Human
Applications WB, Simple Western

NBP2-55584
Immunocytochemistry/Immunofluorescence: FKRP Antibody [NBP2-55584] - Staining of human cell line SH-SY5Y shows localization to nucleus, cytosol & the Golgi apparatus.

Rabbit Polyclonal
Species Human
Applications ICC/IF

NBP2-57249
Immunocytochemistry/Immunofluorescence: Six3 Antibody [NBP2-57249] - Staining of human cell line SH-SY5Y shows localization to nucleoplasm. Antibody staining is shown in green.

Rabbit Polyclonal
Species Human
Applications ICC/IF

NBP2-24607
Western Blot: Zic2 Antibody [NBP2-24607] - Analysis of ZIC2 in HepG2 cell lysate using 1) pre-bleed, and 2) this antibody.  Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

Rabbit Polyclonal
Species Human, Mouse, Bovine
Applications WB

AF4634
Western blot shows lysates of human brain (cortex) tissue and human brain (hippocampus) tissue. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human GPR56 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4634) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # <A class=NoLineLink href=<p align=

Sheep Polyclonal
Species Human
Applications WB, Simple Western, Flow

     1 Review

2 Publications
NBP1-86152
Western Blot: POMT2 Antibody [NBP1-86152] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells). Lane 2: NBT-II cell lysate (Rat Wistar bladder tumor cells).Immunohistochemistry-Paraffin: POMT2 Antibody [NBP1-86152] - Staining of human prostate shows strong granular cytoplasmic positivity in glandular cells.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC, IHC-P

NB110-41404
Western Blot: Glutamine Synthetase Antibody [NB110-41404] - Analysis of glutamine synthase. 40ug of lysates from mouse (Lanes M), rat (Lane R), pig (Lane P), bovine (Lane B), or human (Lane Hu) retina were probed. A 42 kDa band was identified in lysates from retinas of all species.Immunocytochemistry/Immunofluorescence: Glutamine Synthetase Antibody [NB110-41404] - Immunofluorescence using NB110-41404. Submitted via verified customer review.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

     1 Review

4 Publications

Related Genes

Congenital Anomaly Of Brain has been researched against:

Related PTMs

Congenital Anomaly Of Brain has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Congenital Anomaly Of Brain is also known as Brain Malformation, Brain Malformations, Congenital Brain Anomaly, Deformity Of Brain.