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Cadasil Syndrome: Disease Bioinformatics

Research of Cadasil Syndrome has been linked to Arteriopathic Disease, Leukoencephalopathies, Dementia, Cerebrovascular Accident, Multi-infarct Dementia. The study of Cadasil Syndrome has been mentioned in research publications which can be found using our bioinformatics tool below. Researched pathways related to Cadasil Syndrome include Pathogenesis, Cognition, Notch Signaling Pathway, Aging, Segmentation. These pathways complement our catalog of research reagents for the study of Cadasil Syndrome including antibodies and ELISA kits against NOTCH, ACAT1, JAG1, SLC25A5, APOE.

Cadasil Syndrome Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Cadasil Syndrome below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 1046 products for the study of Cadasil Syndrome that can be applied to Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Chromatin Immunoprecipitation (ChIP), Immunohistochemistry from our catalog of antibodies and ELISA kits.

H00004854-M01
ELISA: Notch-3 Antibody (1G5) [H00004854-M01] - Detection limit for recombinant GST tagged NOTCH3 is approximately 0.03ng/ml as a capture antibody.

Mouse Monoclonal
Species Human
Applications WB, ELISA

     1 Review

9 Publications
NB100-93551
Western Blot: Notch-4 Antibody [NB100-93551] - Analysis of Notch-4 in 1. Jurkat 2. U937 3. WEHI 4. Raw267 cell lysates.Immunocytochemistry/Immunofluorescence: Notch-4 Antibody [NB100-93551] -  Notch-4 antibody (1:500) was tested in HeLa cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). Image objective 20x.

Rabbit Polyclonal
Species Human
Applications WB, ELISA, ICC/IF

1 Publication
NBP1-51843
Western Blot: Aurora A Antibody [NBP1-51843] - WB detection of Aurora A in HeLa whole cell lysate.Immunocytochemistry/Immunofluorescence: Aurora A Antibody [NBP1-51843] - IF Confocal analysis of HeLa cells using Aurora A antibody (NBP1-51843, 1:10). An Alexa Fluor 488-conjugated Goat to rabbit IgG was used as secondary antibody (green). Actin filaments were labeled with Alexa Fluor 568 phalloidin (red). DAPI was used to stain the cell nuclei (blue).

Rabbit Polyclonal
Species Human, Mouse
Applications WB, Simple Western, ICC/IF

     1 Review

4 Publications
NBP2-23869
Western Blot: HTRA1/PRSS11 Antibody [NBP2-23869] -  Analysis of HtrA1 in human A) HeLa cell lysate (1 minute exposure) and B) human 293 cell lysate (15 minute exposure) using NBP2-23869 at 1:500.Simple Western: HTRA1/PRSS11 Antibody [NBP2-23869] - Simple Western lane view shows a specific band for htrA1 in 0.5 mg/ml of Hek293 lysate.  This experiment was performed under reducing conditions using the 12-230 kDa separation system.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, ICC/IF

2 Publications
236-EG
Recombinant Human EGF (Catalog # 236‑EG) stimulates cell proliferation of the Balb/3T3 mouse embryonic fibroblast cell line. The ED<sub>50</sub> for this effect is 20‑100 pg/mL.1 µg/lane of Recombinant Human EGF was resolved with SDS-PAGE  and visualized by silver staining under reducing (R) conditions, showing a single band at 6 kDa.


Species Human

     10 Reviews

282 Publications
NB100-78486
Western Blot: Notch-1 Antibody (mN1A) [NB100-78486] - Cell extracts from Jurkat (Lane 1) or mouse thymocytes (Lane 2) were Western Blot analyzed with monoclonal anti-NOTCH1 antibody. The mN1A antibody recognizes both mouse and human 270 kD full-length NOTCH1 and 110-120 kD cleaved NOTCH 1 (NICD).Immunocytochemistry/Immunofluorescence: Notch-1 Antibody (mN1A) [NB100-78486] -  The Notch1 Antibody was tested in HEK293 cells at a 1:50 dilution against Dylight 488 (Green).  Actin was counterstained against Phalloidin 568 (Red) and cells were mounted in DAPI Flouromount (Blue).

Mouse Monoclonal
Species Human, Mouse, Rat (Negative)
Applications WB, Flow, ICC/IF

     1 Review

6 Publications
NBP1-89285
Western Blot: ACAT1 Antibody [NBP1-89285] - Analysis in mouse cell line NIH-3T3 and rat cell line NBT-II.Immunocytochemistry/Immunofluorescence: ACAT1 Antibody [NBP1-89285] - Immunofluorescent staining of human cell line A-431 shows localization to mitochondria. Antibody staining is shown in green.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

3 Publications
NBP2-56762
Western Blot: Adenine Nucleotide Translocator 2 Antibody [NBP2-56762] - Western blot analysis in human cell line RT-4 and human cell line U-251 MG.Immunocytochemistry/Immunofluorescence: Adenine Nucleotide Translocator 2 Antibody [NBP2-56762] - Staining of human cell line PC-3 shows localization to mitochondria.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF

NBP2-29617
Western Blot: TREX1 Antibody [NBP2-29617] - WB analysis of TREX1 partial recombinant protein by using TREX1 antibody at a concentration of 1ug/ml.Immunohistochemistry-Frozen: TREX1 Antibody [NBP2-29617] - IHC analysis of formalin-fixed paraffin-embedded tissue section of human normal stomach using rabbit polyclonal TREX1 antibody at 7.5 ug/ml concentration. Specific cytoplasmic and nuclear staining was observed in the glandular cells/mucosal epithelium of stomach [Magnification 10X].

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-Fr

AF4079

Goat Polyclonal
Species Human
Applications WB, ICC

     1 Review

MAB3818
RAW 264.7 mouse monocyte/macrophage cell line was stained with Rat Anti-Mouse M-CSF R/CD115 Monoclonal Antibody (Catalog # MAB3818, filled histogram) or isotype control antibody (Catalog # <a class=

Rat Monoclonal
Species Mouse
Applications Flow, CyTOF-ready

3 Publications
215-GM/CF
1 μg/lane of Recombinant Human GM-CSF was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 14 kDa.Recombinant Human GM-CSF (Catalog # 215-IL/CF) stimulates cell proliferation of the TF-1 human erythroleukemic cell line. The ED<sub>50</sub> for this effect is 6-30 pg/mL.


Species Human

195 Publications
NBP2-42388
Western Blot: LAMC2 Antibody (CL2980) [NBP2-42388] - Analysis in A-431 cells transfected with control siRNA, target specific siRNA probe #1 and #2, using Anti-LAMC2 antibody. Remaining relative intensity is presented. Loading control: Anti-GAPDH.Immunohistochemistry-Paraffin: LAMC2 Antibody (CL2980) [NBP2-42388] - Staining in human fallopian tube and liver tissues. Corresponding LAMC2 RNA-seq data are presented for the same tissues.

Mouse Monoclonal
Species Human
Applications WB, IHC, IHC-P

NBL1-12165
Western Blot: KCNJ13 Overexpression Lysate (Adult Normal) [NBL1-12165] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for KCNJ13.


Species Human

NBP2-50051
Western Blot: Tau Antibody (5B10) [NBP2-50051] - Analysis of crude rat brain extract stained with NBP2-50051, revealing, as expected, multiple bands in the range 48-67kDa.Immunocytochemistry/Immunofluorescence: Tau Antibody (5B10) [NBP2-50051] - E18 rat brain cultures were grown for 10 days, fixed and immunostained with NBP2-50051 in red and chicken antibody to MAP2 (NB300-213, green) and for DNA (blue). NBP2-50051 stains the neuronal perikarya, dendrites and axonal process strongly and does not stain non neuronal cells in these cultures. The MAP2 antibody also stains neurons only, but only the perikarya and dendrites. As a result perikarya and dendrites appears yellow, since they contain both tau and MAP2, while axons appear red as they contain only tau.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF

NB110-60531
Immunohistochemistry-Paraffin: Apolipoprotein E/ApoE Antibody (WUE-4) [NB110-60531] - ApoE was detected in immersion fixed paraffin-embedded sections of human liver using anti-human mouse monoclonal antibody (Catalog # NB110-60531) at 1:200 dilution overnight at 4 C. Tissue was stained using the VisuCyte anti-mouse HRP polymer detection reagent (Catalog # VC001) with DAB chromogen (brown) and counterstained with hematoxylin (blue).<br/>Images may not be copied, printed or otherwise disseminated without express written permission of Novus Biologicals a bio-techne brand.Western Blot: Apolipoprotein E/ApoE Antibody (WUE-4) [NB110-60531] - ApoE Antibody (WUE-4) [NB110-60531] - Detection of ApoE in human tissue lysate using NB110-60531. Lane 1: liver Lane 2: brain

Mouse Monoclonal
Species Human, Mouse, Rat (Negative)
Applications WB, ELISA, Flow

     2 Reviews

12 Publications
NBP2-37607
Western Blot: MTHFR Antibody (5D3) [NBP2-37607] - Western blot analysis using MTHFR mouse mAb against Rat Heart cell lysate.Immunohistochemistry: MTHFR Antibody (5D3) [NBP2-37607] - Immunohistochemical analysis of paraffin-embedded lung cancer using MTHFR mouse mAb with DAB staining.

Mouse Monoclonal
Species Human, Rat
Applications WB, ELISA, IHC

1277-JG


Species Human

     1 Review

16 Publications
NBP2-13075
Immunohistochemistry: beta Amyloid Antibody (MOAB-2) [NBP2-13075] - IHC analysis of beta Amyloid on normal mouse brain (left) and 5xFAD mouse brain (right) using DAB with hematoxylin counterstain.  The MOAB-2 antibody was used at 1:20 on normal mouse brain and at 1:400 on 5xFAD mouse brain.Immunohistochemistry-Paraffin: beta Amyloid Antibody (MOAB-2) [NBP2-13075] - IHC analysis of a formalin fixed paraffin embedded tissue section of human brain (Alzheimers disease, hippocampus) using 1:200 dilution of anti-beta Amyloid antibody (clone MOAB-2). The staining was developed with HRP labeled anti-mouse secondary antibody and DAB reagent, and nuclei of cells were counter-stained with hematoxylin. This beta Amyloid antibody specifically stained the cells with Abeta 42/ Abeta aggregates while the normal cells were negative for abeta peptide.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, ICC/IF

12 Publications

Related Genes

Cadasil Syndrome has been researched against:

Related PTMs

Cadasil Syndrome has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Cadasil Syndrome is also known as Cadasil, Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy, Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts And Leucoencephalopathy, Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts And Leukoencephalopathy.