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Brain Stem Glioblastoma: Disease Bioinformatics

A brain stem glioblastoma is a primary brain tumor involving glial cells. It is aggressive, malignant, and starts in the brain or spinal cord and often spreads throughout the nervous system. The tumors arise from astrocytes, or cells that exist in the supportive tissue of the brain. The exact cause of this tumor is not known, but an important gene associated with a brain glioblastoma is the TNSF13 gene. The large amount of blood flow that continuously goes throughout the brain facilitates the rapid growth of this tumor. There are primary and secondary forms of brain stem glioblastoma, with the primary following a very rapid progression and the secondary beginning as lower grade tumors and eventually becoming higher grade. The most common symptoms occur due to an increased pressure on the brain stem, and include headaches, nausea, double vision, and seizures. The standard treatment is surgery to remove the tumor, but the aggressive nature of the glioblastoma frequently makes that impossible.

Brain Stem Glioblastoma Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Brain Stem Glioblastoma below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 984 products for the study of Brain Stem Glioblastoma that can be applied to Western Blot, Flow Cytometry, Chromatin Immunoprecipitation, Immunocytochemistry/Immunofluorescence, Chromatin Immunoprecipitation (ChIP), Immunohistochemistry from our catalog of antibodies and ELISA kits.

Western Blot: n-Myc Antibody (NMYC-1) [NB200-109] - Western blot analysis of n-Myc expression in IMR32 whole cell lysate.Immunocytochemistry/ Immunofluorescence: n-Myc Antibody (NMYC-1) [NB200-109] - The n-Myc (NMYC-1) antibody was tested in NTERA2 cells at a 1:50 dilution against Dylight 488 (Green). Actin and nuclei were counterstained against Phalloidin 568 (Red) and DAPI (Blue), respectively.

Mouse Monoclonal
Species Human, Mouse
Applications WB, ChIP, GS

3 Publications
Western Blot: Doublecortin Antibody (3E1) [NBP1-92684] - Western blot of crude rat brain extract from a postnatal 3 day animal stained with NBP1-92684. Two bands at ~45kDa and ~35kDa show that NBP1-92684 binds to an epitope in the region of Doublecortin shared by Lis-A, and Lis-B, Lis-C and Lis-D, the C terminal 360 amino acids of Lis-A.Immunocytochemistry/Immunofluorescence: Doublecortin Antibody (3E1) [NBP1-92684] - Rat brain neural cultures stained with NBP1-92684 (green), a chicken polyclonal antibody to GFAP (NB300-213, red) and DNA (blue). The NBP1-92684 antibody reveals strong cytoplasmic staining in a population of small developing neurons. These cells are often found in small clumps as in these cultures, as in this example. Note that they are not positive for MAP2, which is characteristic of more mature neurons, and that the mature neuron shown is negative for NBP1-92684. This Doublecortin antibody is therefore an excellent marker of developing neuronal cells.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF

Western Blot: Transglutaminase 1/TGM1 Antibody [NB100-1844] - Antibody at 1/200 dilution of an extract from human epidermis.Immunocytochemistry/Immunofluorescence: Transglutaminase 1/TGM1 Antibody [NB100-1844] - Epidermal keratinocytes from neonatal foreskin stained in immunofluorscene with Transglutaminase

Rabbit Polyclonal
Species Human
Applications WB, ELISA, ICC/IF

2 Publications
Western Blot: CD4 Antibody [NBP1-19371] - CD4 antibody was tested in the following cell lysates: Lane 1) human spleen 2) human tonsil 3) human placenta 4) human kidney 5) human liver 6) mouse spleen 7) mouse placenta 8) rat placenta.Immunocytochemistry/Immunofluorescence: CD4 Antibody [NBP1-19371] - CD4 antibody was tested in Jurkat cells with Dylight 488 (green). Nuclei were counterstained with DAPI (blue).

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, ICC/IF

     5 Reviews

8 Publications
Western Blot: NLRP5 Antibody [NBP1-76289] - Mouse brain tissue lysate with NLRP5 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.Immunohistochemistry: NLRP5 Antibody [NBP1-76289] - Immunohistochemistry of NALP5 in human brain tissue with NALP5 antibody at 10 ug/mL.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ELISA, ICC/IF

Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line and rat and mouse brain tissue. PVDF membrane was probed with 0.5 µg/mL Mouse Anti-Human/Mouse/Rat PTEN Monoclonal Antibody (Catalog # MAB847) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # <a class=PTEN was detected in immersion fixed paraffin-embedded sections of human liver array using Mouse Anti-Human/Mouse/Rat PTEN Monoclonal Antibody (Catalog # MAB847) at 25 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # <a class=

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, IHC, ICFlow

1 Publication
Western blot shows lysates of MCF‑7 human breast cancer cell line untreated (-) or treated (+) with 1 µM Camptothecin (CPT) for 5 hours. PVDF membrane was probed with 1:1000 dilution of Rabbit Anti-Human Phospho-p53 (S46) Monoclonal Antibody (Catalog # MAB1489) followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # <A class=NoLineLink href=

Rabbit Monoclonal
Species Human
Applications WB

Related Genes

Brain Stem Glioblastoma has been researched against:

Related Pathways

Brain Stem Glioblastoma has been linked to:

Related PTMs

Alternate Names

Brain Stem Glioblastoma is also known as Brain Stem Glioblastoma Multiforme, Brainstem Glioblastoma, Brainstem Glioblastoma Multiforme, Glioblastoma Multiforme Of Brainstem, Glioblastoma Multiforme Of The Brain Stem.