Brain edema is characterized by an excess accumulation of fluid in the intracellular or extracellular spaces of the brain. A vasogenic brain edema arises with the breakdown of the tight endothelial junctions of the blood vessels of the brain, which are part of the blood brain barrier. The breakdown of the endothelial junctions can be caused by a brain injury, cancerous cells, and hypoxia. When proteins and other plasma constituents are able to cross the blood brain barrier, a rapid swelling in the extracellular space occurs. Symptoms of a brain edema depend on the severity and cause of the disorder, and can include headaches, nausea, vision loss, seizures, and a loss of consciousness. There are a variety of treatments that doctors use to reduce a brain edema, including oxygen therapy, medications, and surgery in extreme cases. It is common to have long term effects from a brain edema in terms of both cognitive and physical functions.
Brain Edema, Vasogenic Bioinformatics Tool
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